Kliniken &… Kliniken Kopfklinik… Hals-, Nasen- und… Forschung Publication List

Peer Reviewed Articles


De Ponti, A. M., L. Wiechert, A. Stojanovic, T. Longerich, S. Marhenke, N. Hogg, A. Vogel, A. Cerwenka, P. Schirmacher, J. Hess and P. Angel (in press). "Chronic liver inflammation and hepatocellular carcinogenesis are independent of S100A9." Int J Cancer.

Fernández-Ulibarri, I., K. Hammer, M. Arndt, J. K. Kaufmann, D. Dorer, S. Engelhardt, R. E. Kontermann, J. Hess, H. Allgayer, J. Krauss and D. Nettelbeck (in press). "Genetic delivery of an immunornase by an oncolytic adenovirus enhances anticancer activity." Int J Cancer.

Funk, S., R. Mark, P. Bayo, C. Flechtenmacher, N. Grabe, P. Angel, P. K. Plinkert and J. Hess (in press). "High S100A8 and S100A12 protein expression is a favorable prognostic factor for survival of oropharyngeal squamous cell carcinoma." Int J Cancer.

Koffler, J., S. Sharma and J. Hess (in press). "Predictive value of epigenetic alterations in head and neck squamous cell carcinoma." Mol Cell Oncol.

Horwitz, E., I. Stein, M. Andreozzi, J. Nemeth, A. Shoham, O. Pappo, N. Schweitzer, L. Tornillo, N. Kanarek, L. Quagliata, F. Zreik, R. M. Porat, R. Finkelstein, H. Reuter, R. Koschny, T. Ganten, C. Mogler, O. Shibolet, J. Hess, K. Breuhahn, M. Grunewald, P. Schirmacher, A. Vogel, L. Terracciano, P. Angel, Y. Ben-Neriah and E. Pikarsky (2014). "Human and mouse VEGFA-amplified hepatocellular carcinomas are highly sensitive to sorafenib treatment." Cancer Discov 4(6): 730-743.

Schumacher, M., C. Schuster, Z. M. Rogon, T. Bauer, N. Caushaj, S. Baars, S. Szabowski, C. Bauer, M. Schorpp-Kistner, J. Hess, S. Holland-Cunz, E. F. Wagner, R. Eils, P. Angel and B. Hartenstein (2014). "Efficient Keratinocyte Differentiation Strictly Depends on JNK-Induced Soluble Factors in Fibroblasts." J Invest Dermatol 134(5): 1332-1341.


Mark, R., J. L. Bermejo, A. Bierhaus, P. K. Plinkert, P. Angel and J. Hess (2013). The receptor for advanced glycation end products is dispensable in a mouse model of oral and esophageal carcinogenesis. Histol Histopathol 28(12): 1585-94.

Holzinger, D., C. Flechtenmacher, N. Henfling, I. Kaden, N. Grabe, B. Lahrmann, M. Schmitt, J. Hess, M. Pawlita and F. X. Bosch (2013). Identification of oropharyngeal squamous cell carcinomas with active HPV16 involvement by immunohistochemical analysis of the retinoblastoma protein pathway. Int J Cancer 133(6): 1389-1399.

Pusterla, T., J. Nemeth, I. Stein, L. Wiechert, D. Knigin, S. Marhenke, T. Longerich, V. Kumar, B. Arnold, A. Vogel, A. Bierhaus, E. Pikarsky, J. Hess* and P. Angel* (2013). Rage is a key regulator of oval cell activation and inflammation-associated liver carcinogenesis in mice. Hepatology 58(1):363-73. *equal contribution.

Kostareli, E., D. Holzinger, O. Bogatyrova, T. Hielscher, G. Wichmann, M. Keck, B. Lahrmann, N. Grabe, C. Flechtenmacher, C. R. Schmidt, T. Seiwert, G. Dyckhoff, A. Dietz, D. Hofler, M. Pawlita, A. Benner, F. X. Bosch, P. Plinkert, C. Plass, D. Weichenhan and J. Hess (2013). HPV-related methylation signature predicts survival in oropharyngeal squamous cell carcinomas. J Clin Invest 123(6): 2488-2501.

Leibold, J. S., A. Riehl, J. Hettinger, M. Durben, J. Hess and P. Angel (2013). Keratinocyte-Specific Deletion of the Receptor RAGE Modulates the Kinetics of Skin Inflammation in vivo. J Invest Dermatol 133(10): 2400-6.

Koffler, J., D. Holzinger, G. A. Sanhueza, C. Flechtenmacher, K. Zaoui, B. Lahrmann, N. Grabe, P. K. Plinkert and J. Hess (2013). Submaxillary gland androgen-regulated protein 3A expression is an unfavorable risk factor for the survival of oropharyngeal squamous cell carcinoma patients after surgery. Eur Arch Otorhinolaryngol 270(4): 1493-1500.

Finimundy, T. C., G. Gambato, R. Fontana, M. Camassola, M. Salvador, S. Moura, J. Hess, J. A. Henriques, A. J. Dillon and M. Roesch-Ely (2013). Aqueous extracts of Lentinula edodes and Pleurotus sajor-caju exhibit high antioxidant capability and promising in vitro antitumor activity. Nutr Res 33(1): 76-84.


Kostareli, E., D. Holzinger and J. Hess (2012). New concepts for translational head and neck oncology: lessons from HPV-related oropharyngeal squamous cell carcinomas. Front Head Neck Cancer 2: 1-10.

Singer, S., R. Zhao, A. M. Barsotti, A. Ouwehand, M. Fazollahi, E. Coutavas, K. Breuhahn, O. Neumann, T. Longerich, T. Pusterla, M. A. Powers, K. M. Giles, P. J. Leedman, J. Hess, D. Grunwald, H. J. Bussemaker, R. H. Singer, P. Schirmacher and C. Prives (2012). Nuclear pore component Nup98 is a potential tumor suppressor and regulates posttranscriptional expression of select p53 target genes. Mol Cell 48(5): 799-810.

Wiechert, L., J. Nemeth, T. Pusterla, C. Bauer, A. De Ponti, S. Manthey, S. Marhenke, A. Vogel, U. Klingmuller, J. Hess* and P. Angel* (2012). Hepatocyte-specific S100a8 and S100a9 transgene expression in mice causes Cxcl1 induction and systemic neutrophil enrichment. Cell Commun Signal 10(1): 40. *equal contribution.

Acuna Sanhueza, G. A., L. Faller, B. George, J. Koffler, V. Misetic, C. Flechtenmacher, G. Dyckhoff, P. P. Plinkert, P. Angel, C. Simon and J. Hess (2012). Opposing function of MYBBP1A in proliferation and migration of head and neck squamous cell carcinoma cells. BMC Cancer 12: 72.

Peterziel, H., J. Muller, A. Danner, S. Barbus, H. K. Liu, B. Radlwimmer, T. Pietsch, P. Lichter, G. Schutz, J. Hess and P. Angel (2012). Expression of podoplanin in human astrocytic brain tumors is controlled by the PI3K-AKT-AP-1 signaling pathway and promoter methylation. Neuro Oncol 14(4): 426-439.


Hess, J., and P. Angel (2011). The Transcription Factor AP-1 in Squamous Cell Carcinogenesis: Lessons from Mouse Models of Skin Carcinogenesis. In: Signaling Pathways in Squamous Cancer, First Edition. A.B. Glick and C. van Waes (Eds.), Springer Science and Business Media. LLC.

Krenzer, S., H. Peterziel, C. Mauch, S. I. Blaber, M. Blaber, P. Angel and J. Hess (2011). Expression and function of the kallikrein-related peptidase 6 in the human melanoma microenvironment. J Invest Dermatol 131(11): 2281-2288.

Lazic, D., F. Alborzi, G. P. Marcuzzi, P. Angel, J. Hess, H. Pfister and B. Akgul (2011). Enhanced StefinA and Sprr2 expression during papilloma formation in HPV8 transgenic mice. J Dermatol Sci 62(2): 84-90.


Nemeth, J., P. Angel and J. Hess (2010). Dual Role of S100A8 and S100A9 in Inflammation-Associated Cancer. Anti-Inflammatory Anti-Allergy Agents in Medical Chemistry 8(4): 329-336.

Riehl, A., T. Bauer, B. Brors, H. Busch, R. Mark, J. Nemeth, C. Gebhardt, A. Bierhaus, P. Nawroth, R. Eils, R. Konig, P. Angel and J. Hess (2010). Identification of the Rage-dependent gene regulatory network in a mouse model of skin inflammation. BMC Genomics 11(1): 537.

Hildenbrand, M., V. Rhiemeier, B. Hartenstein, B. Lahrmann, N. Grabe, P. Angel and J. Hess (2010). Impaired skin regeneration and remodeling after cutaneous injury and chemically induced hyperplasia in taps-transgenic mice. J Invest Dermatol 130(7): 1922-1930.


Angel, P., and Hess J (2009). AP-1. In: Encyclopedic Reference of Cancer, Second Edition. Manfred Schwab (Ed.), Springer Verlag Heidelberg.

Angel, P., and Hess J (2009). The multi-gene family of transcription factor AP-1. In: Handbook of Cell signaling, Second Edition. R. Bradshaw and E. Dennis (Ed.), Elsevier Science San Diego, CA, USA.

Riehl, A., J. Nemeth, P. Angel and J. Hess (2009). The receptor RAGE: Bridging inflammation and cancer. Cell Commun Signal 7: 12.

Durchdewald, M., P. Angel and J. Hess (2009). The transcription factor Fos: a Janus-type regulator in health and disease. Histol Histopathol 24(11): 1451-1461.

Ernst, A., S. Hofmann, R. Ahmadi, N. Becker, A. Korshunov, F. Engel, C. Hartmann, J. Felsberg, M. Sabel, H. Peterziel, M. Durchdewald, J. Hess, S. Barbus, B. Campos, A. Starzinski-Powitz, A. Unterberg, G. Reifenberger, P. Lichter, C. Herold-Mende and B. Radlwimmer (2009). Genomic and expression profiling of glioblastoma stem cell-like spheroid cultures identifies novel tumor-relevant genes associated with survival. Clin Cancer Res 15(21): 6541-6550.

Nemeth, J., I. Stein, D. Haag, A. Riehl, T. Longerich, E. Horwitz, K. Breuhahn, C. Gebhardt, P. Schirmacher, M. Hahn, Y. Ben-Neriah, E. Pikarsky, P. Angel and J. Hess (2009). S100A8 and S100A9 are novel nuclear factor kappa B target genes during malignant progression of murine and human liver carcinogenesis. Hepatology 50(4): 1251-1262.

Laumen, H., A. D. Saningong, I. M. Heid, J. Hess, C. Herder, M. Claussnitzer, J. Baumert, C. Lamina, W. Rathmann, E. M. Sedlmeier, N. Klopp, B. Thorand, H. E. Wichmann, T. Illig and H. Hauner (2009). Functional characterization of promoter variants of the adiponectin gene complemented by epidemiological data. Diabetes 58(4): 984-991.


Durchdewald, M., J. Guinea-Viniegra, D. Haag, A. Riehl, P. Lichter, M. Hahn, E. F. Wagner, P. Angel and J. Hess (2008). Podoplanin is a novel fos target gene in skin carcinogenesis. Cancer Res 68(17): 6877-6883.

Gebhardt, C., A. Riehl, M. Durchdewald, J. Nemeth, G. Furstenberger, K. Muller-Decker, A. Enk, B. Arnold, A. Bierhaus, P. P. Nawroth, J. Hess* and P. Angel* (2008). RAGE signaling sustains inflammation and promotes tumor development. J Exp Med 205(2): 275-285. *equal contribution.


Fries, F., I. Nazarenko, J. Hess, A. Claas, P. Angel and M. Zoller (2007). CEBPbeta, JunD and c-Jun contribute to the transcriptional activation of the metastasis-associated C4.4A gene. Int J Cancer 120(10): 2135-2147.

Klucky, B., R. Mueller, I. Vogt, S. Teurich, B. Hartenstein, K. Breuhahn, C. Flechtenmacher, P. Angel and J. Hess (2007). Kallikrein 6 induces e-cadherin shedding and promotes cell proliferation, migration, and invasion. Cancer Res 67(17): 8198-8206.

Haase, D., M. Meister, T. Muley, J. Hess, S. Teurich, P. Schnabel, B. Hartenstein and P. Angel (2007). FRMD3, a novel putative tumour suppressor in NSCLC. Oncogene 26(30): 4464-4468.


Gebhardt, C., J. Nemeth, P. Angel and J. Hess (2006). S100A8 and S100A9 in inflammation and cancer. Biochem Pharmacol 72(11): 1622-1631.

Bourcier, C., A. Jacquel, J. Hess, I. Peyrottes, P. Angel, P. Hofman, P. Auberger, J. Pouyssegur and G. Pages (2006). p44 mitogen-activated protein kinase (extracellular signal-regulated kinase 1)-dependent signaling contributes to epithelial skin carcinogenesis. Cancer Res 66(5): 2700-2707.

Hummerich, L., R. Muller, J. Hess, F. Kokocinski, M. Hahn, G. Furstenberger, C. Mauch, P. Lichter and P. Angel (2006). Identification of novel tumour-associated genes differentially expressed in the process of squamous cell cancer development. Oncogene 25(1): 111-121.

Rhiemeier, V., U. Breitenbach, K. H. Richter, C. Gebhardt, I. Vogt, B. Hartenstein, G. Furstenberger, C. Mauch, J. Hess and P. Angel (2006). A novel aspartic proteinase-like gene expressed in stratified epithelia and squamous cell carcinoma of the skin. Am J Pathol 168(4): 1354-1364.


Hermani, A., J. Hess, B. De Servi, S. Medunjanin, R. Grobholz, L. Trojan, P. Angel and D. Mayer (2005). Calcium-binding proteins S100A8 and S100A9 as novel diagnostic markers in human prostate cancer. Clin Cancer Res 11(14): 5146-5152.

Gebhardt, C., U. Breitenbach, K. H. Richter, G. Furstenberger, C. Mauch, P. Angel and J. Hess (2005). c-Fos-Dependent Induction of the Small Ras-Related GTPase Rab11a in Skin Carcinogenesis. Am J Pathol 167(1): 243-253.


Hess, J., P. Angel and M. Schorpp-Kistner (2004). AP-1 subunits: quarrel and harmony among siblings. J Cell Sci 117(Pt 25): 5965-5973.

Marinkovic, D., T. Marinkovic, B. Mahr, J. Hess and T. Wirth (2004). Reversible lymphomagenesis in conditionally c-MYC expressing mice. Int J Cancer 110(3): 336-342.


Baumann, S., J. Hess, S. T. Eichhorst, A. Krueger, P. Angel, P. H. Krammer and S. Kirchhoff (2003). An unexpected role for FosB in activation-induced cell death of T cells. Oncogene 22(9): 1333-1339.

Hess, J., B. Hartenstein, S. Teurich, D. Schmidt, M. Schorpp-Kistner and P. Angel (2003). Defective endochondral ossification in mice with strongly compromised expression of JunB. J Cell Sci 116(Pt 22): 4587-4596.

Schlingemann, J., J. Hess, G. Wrobel, U. Breitenbach, C. Gebhardt, P. Steinlein, H. Kramer, G. Furstenberger, M. Hahn, P. Angel and P. Lichter (2003). Profile of gene expression induced by the tumour promotor TPA in murine epithelial cells. Int J Cancer 104(6): 699-708.

Bierbaum, H., S. Baumann, I. Herr, J. P. Tuckermann, J. Hess, M. Schorpp-Kistner and P. Angel (2003). Early activation and induction of apoptosis in T cells is independent of c-Fos. Ann N Y Acad Sci 1010: 225-231.


Hartenstein, B., S. Teurich, J. Hess, J. Schenkel, M. Schorpp-Kistner and P. Angel (2002). Th2 cell-specific cytokine expression and allergen-induced airway inflammation depend on JunB. EMBO J 21(23): 6321-6329.

Samardzic, T., J. Gerlach, K. Muller, D. Marinkovic, J. Hess, L. Nitschke and T. Wirth (2002). CD22 regulates early B cell development in BOB.1/OBF.1-deficient mice. Eur J Immunol 32(9): 2481-2489.


Hess, J., D. Porte, C. Munz and P. Angel (2001). AP-1 and Cbfa/runt physically interact and regulate parathyroid hormone-dependent MMP13 expression in osteoblasts through a new osteoblast-specific element 2/AP-1 composite element. J Biol Chem 276(23): 20029-20038.

Hess, J., A. Werner, T. Wirth, F. Melchers, H. M. Jack and T. H. Winkler (2001). Induction of pre-B cell proliferation after de novo synthesis of the pre-B cell receptor. Proc Natl Acad Sci U S A 98(4): 1745-1750.

Hess, J., P. J. Nielsen, K. D. Fischer, H. Bujard and T. Wirth (2001). The B lymphocyte-specific coactivator BOB.1/OBF.1 is required at multiple stages of B-cell development. Mol Cell Biol 21(5): 1531-1539.


Greiner, A., K. B. Muller, J. Hess, K. Pfeffer, H. K. Muller-Hermelink and T. Wirth (2000). Up-regulation of BOB.1/OBF.1 expression in normal germinal center B cells and germinal center-derived lymphomas. Am J Pathol 156(2): 501-507.


Hess, J., H. Laumen, K. B. Muller and T. Wirth (1998). Molecular genetics of the germinal center reaction. J Cell Physiol 177(4): 525-534.

Hess, J., H. Laumen and T. Wirth (1998). Application of differential cDNA screening techniques to the identification of unique gene expression in tumours and lymphocytes. Curr Opin Immunol 10(2): 125-130.


Pfisterer, P., J. Hess and T. Wirth (1997). Identification of target genes of the lymphoid-specific transcription factor Oct2. Immunobiology 198(1-3): 217-226.


Pfisterer, P., H. Konig, J. Hess, G. Lipowsky, B. Haendler, W. D. Schleuning and T. Wirth (1996). "CRISP-3, a protein with homology to plant defense proteins, is expressed in mouse B cells under the control of Oct2." Mol Cell Biol 16(11): 6160-6168.


Pfisterer, P., S. Zwilling, J. Hess and T. Wirth (1995). Functional characterization of the murine homolog of the B cell-specific coactivator BOB.1/OBF.1. J Biol Chem 270(50): 29870-29880.