Kliniken & Institute … Kliniken Zentrum für Innere… Institut für… Forschung Publikationen

Publikationen

Tadros R, Francis C, Xu X, Vermeer AMC, Harper AR, Huurman R, Kelu Bisabu K, Walsh R, Hoorntje ET, Te Rijdt WP, Buchan RJ, van Velzen HG, van Slegtenhorst MA, Vermeulen JM, Offerhaus JA, Bai W, de Marvao A, Lahrouchi N, Beekman L, Karper JC, Veldink JH, Kayvanpour E, Pantazis A, Baksi AJ, Whiffin N, Mazzarotto F, Sloane G, Suzuki H, Schneider-Luftman D, Elliott P, Richard P, Ader F, Villard E, Lichtner P, Meitinger T, Tanck MWT, van Tintelen JP, Thain A, McCarty D, Hegele RA, Roberts JD, Amyot J, Dubé MP, Cadrin-Tourigny J, Giraldeau G, L'Allier PL, Garceau P, Tardif JC, Boekholdt SM, Lumbers RT, Asselbergs FW, Barton PJR, Cook SA, Prasad SK, O'Regan DP, van der Velden J, Verweij KJH, Talajic M, Lettre G, Pinto YM, Meder B, Charron P, de Boer RA, Christiaans I, Michels M, Wilde AAM, Watkins H, Matthews PM, Ware JS, Bezzina CR. Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect. Nature Genetics 2021

Yilmaz A, Bauersachs J, Bengel F, Büchel R, Kindermann I, Klingel K, Knebel F, Meder B, Morbach C, Nagel E, Schulze-Bahr E, Aus dem Siepen F, Frey N. Diagnosis and treatment of cardiac amyloidosis: position statement of the German Cardiac Society (DGK). Clin Res Cardiol. 2021 Jan 18. doi: 10.1007/s00392-020-01799-3.

Saberi S, Cardim N, Yamani MH, Schulz-Menger J, Li W, Florea V, Sehnert AJ, Kwong RY, Jerosch-Herold M, Masri A, Owens A, Lakdawala NK, Kramer CM, Sherrid M, Seidler T, Wang A, Sedaghat-Hamedani F, Meder B, Havakuk O, Jacoby D. Mavacamten Favorably Impacts Cardiac Structure in Obstructive Hypertrophic Cardiomyopathy: EXPLORER-HCM CMR Substudy Analysis.Circulation. 2020 Nov 15. doi: 10.1161/CIRCULATIONAHA.120.052359. Online ahead of print.

Herrmann H, Cabet E, Chevalier NR, Moosmann J, Schultheis D, Haas J, Schowalter M, Berwanger C, Weyerer V, Agaimy A, Meder B, Müller OJ, Katus HA, Schlötzer-Schrehardt U, Vicart P, Ferreiro A, Dittrich S, Clemen CS, Lilienbaum A, Schröder R. Dual Functional States of R406W-Desmin Assembly Complexes Cause Cardiomyopathy With Severe Intercalated Disc Derangement in Humans and in Knock-In Mice. Circulation. 2020 Dec;142(22):2155-2171.

Hey TM, Rasmussen TB, Madsen T, Aagaard MM, Harbo M, Mølgaard H, Nielsen SK, Haas J, Meder B, Møller JE, Eiskjær H, Mogensen J. Clinical and Genetic Investigations of 109 Index Patients With Dilated Cardiomyopathy and 445 of Their Relatives. Circ Heart Fail. 2020 Oct;13(10):e006701.

Weng-Tein Gi, Ali Amr, Farbod Sedaghat-Hamedani, Elham Kayvanpour, Isabell Mohr, Manuela Meder, Omid Shirvani Samani, Herbert Fluhr, Hugo A. Katus and Benjamin Meder. Two Hearts at Risk - Emergency Alcohol Septal Ablation in a Pregnant Woman With Decompensated HOCM JACC: Case Reports. Volume 2, Issue 1, January 2020. DOI: 10.1016/j.jaccas.2019.11.053

Sedaghat-Hamedani F, Kayvanpour E, Hamed S, Frankenstein L, Riffel J, Gi WT, Amr A, Shirvani Samani O, Haas J, Miersch T, Herpel E, Kreusser MM, Ehlermann P, Katus HA, Meder B. The chameleon of cardiology: cardiac sarcoidosis before and after heart transplantation. ESC Heart Fail. 2019 Dec 5. doi: 10.1002/ehf2.12581.

Kayvanpour E, Sedaghat-Hamedani F, Gi WT, Tugrul OF, Amr A, Haas J, Zhu F, Ehlermann P, Uhlmann L, Katus HA, Meder B. Clinical and genetic insights into non-compaction: a meta-analysis and systematic review on 7598 individuals. Clin Res Cardiol. 2019 Nov;108(11):1297-1308. doi: 10.1007/s00392-019-01465-3. Epub 2019 Apr 12.

Parikh VN, Caleshu C, Reuter C, Lazzeroni LC, Ingles J, Garcia J, McCaleb K, Adesiyun T, Sedaghat-Hamedani F, Kumar S, Graw S, Gigli M, Stolfo D, Dal Ferro M, Ing AY, Nussbaum R, Funke B, Wheeler MT, Hershberger RE, Cook S, Steinmetz LM, Lakdawala NK, Taylor MRG, Mestroni L, Merlo M, Sinagra G, Semsarian C, Meder B, Judge DP, Ashley E. Regional Variation in RBM20 Causes a Highly Penetrant Arrhythmogenic Cardiomyopathy. Circ Heart Fail. 2019 Mar;12(3):e005371. doi: 10.1161/CIRCHEARTFAILURE.118.005371.

Aurich M, Niemers M, Fuchs P, Greiner S, Müller-Hennessen M, Uhlmann L, Giannitsis E, Ehlermann P, Meder B, Katus HA, Mereles D. Pathophysiological background and prognostic implication of systolic aortic root motion in non-ischemic dilated cardiomyopathy. Sci Rep. 2019 Mar 7;9(1):3866. doi: 10.1038/s41598-019-40386-z.

Bondue A, Arbustini E, Bianco A, Ciccarelli M, Dawson D, De Rosa M, Hamdani N, Hilfiker-Kleiner D, Meder B, Leite-Moreira AF, Thum T, Tocchetti CG, Varricchi G, Van der Velden J, Walsh R, Heymans S. Complex roads from genotype to phenotype in dilated cardiomyopathy: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology. Cardiovasc Res. 2018 Aug 1;114(10):1287-1303. doi: 10.1093/cvr/cvy122. Review.

Sedaghat-Hamedani F, Katus HA, Meder B. Precision medicine for cardiovascular disease: Learning lessons from cardiomyopathies. Herz. 2018 Mar;43(2):123-130. doi: 10.1007/s00059-017-4667-x. Review.

Haas J, Mester S, Lai A, Frese KS, Sedaghat-Hamedani F, Kayvanpour E, Rausch T, Nietsch R, Boeckel JN, Carstensen A, Völkers M, Dietrich C, Pils D, Amr A, Holzer DB, Martins Bordalo D, Oehler D, Weis T, Mereles D, Buss S, Riechert E, Wirsz E, Wuerstle M, Korbel JO, Keller A, Katus HA, Posch AE, Meder B. Genomic structural variations lead to dysregulation of important coding and non-coding RNA species in dilated cardiomyopathy. EMBO Mol Med. 2017 Nov 14. pii: e201707838.

Sedaghat-Hamedani F, Haas J, Zhu F, Geier C, Kayvanpour E, Liss M, Lai A, Frese K, Pribe-Wolferts R, Amr A, Li DT, Samani OS, Carstensen A, Bordalo DM, Müller M, Fischer C, Shao J, Wang J, Nie M, Yuan L, Haßfeld S, Schwartz C, Zhou M, Zhou Z, Shu Y, Wang M, Huang K, Zeng Q, Cheng L, Fehlmann T, Ehlermann P, Keller A, Dieterich C, Streckfuß-Bömeke K, Liao Y, Gotthardt M, Katus HA, Meder B. Clinical genetics and outcome of left ventricular non-compaction cardiomyopathy. Eur Heart J. 2017 Oct 6. doi: 10.1093/eurheartj/ehx545.

Meder B, Haas J, Sedaghat-Hamedani F, Kayvanpour E, Frese K, Lai A, Nietsch R, Scheiner C, Mester S, Martins Bordalo D, Amr A, Dietrich C, Pils D, Siede D, Hund H, Bauer AS, Holzer DB, Ruhparwar A, Mueller-Hennessen M, Weichenhan D, Plass C, Weis TM, Backs J, Wuerstle ML, Keller A, Katus HA, Posch AE. Epigenome-Wide Association Study Identifies Cardiac Gene Patterning and A Novel Class of Biomarkers for Heart Failure. Circulation. 2017 Aug 24. doi: 10.1161/CIRCULATIONAHA.117.027355.

Heinig M, Adriaens ME, Schafer S, van Deutekom HWM, Lodder EM, Ware JS, Schneider V, Felkin LE, Creemers EE, Meder B, Katus HA, Rühle F, Stoll M, Cambien F, Villard E, Charron P, Varro A, Bishopric NH, George AL Jr, Dos Remedios C, Moreno-Moral A, Pesce F, Bauerfeind A, Rüschendorf F, Rintisch C, Petretto E, Barton PJ, Cook SA, Pinto YM, Bezzina CR, Hubner N. Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy. Genome Biol. 2017 Sep 14;18(1):170. doi: 10.1186/s13059-017-1286-z.

Sedaghat-Hamedani F, Kayvanpour E, Tugrul OF, Lai A, Amr A, Haas J, Proctor T, Ehlermann P, Jensen K, Katus HA, Meder B. Clinical outcomes associated with sarcomere mutations in hypertrophic cardiomyopathy: a meta-analysis on 7675 individuals. Clin Res Cardiol. 2017 Aug 24. doi: 10.1007/s00392-017-1155-5.

Seyler C, Meder B, Weis T, Schwaneberg T, Weitmann K, Hoffmann W, Katus HA, Dösch A. TranslatiOnal Registry for CardiomyopatHies (TORCH) - rationale and first results. ESC Heart Fail. 2017 Aug;4(3):209-215. doi: 10.1002/ehf2.12145. Epub 2017 Mar 14. PMID: 28772045

Hecksteden A, Leidinger P, Backes C, Rheinheimer S, Pfeiffer M, Ferrauti A, Kellmann M, Sedaghat F, Meder B, Meese E, Meyer T, Keller A. miRNAs and sports: tracking training status and potentially confounding diagnoses. J Transl Med. 2016 Jul 26;14(1):219. doi: 10.1186/s12967-016-0974-x.

Riffel JH, Keller MG, Rost F, Arenja N, Andre F, Aus dem Siepen F, Fritz T, Ehlermann P, Taeger T, Frankenstein L, Meder B, Katus HA, Buss SJ. Left ventricular long axis strain: a new prognosticator in non-ischemic dilated cardiomyopathy? J Cardiovasc Magn Reson. 2016 Jun 7;18(1):36. doi: 10.1186/s12968-016-0255-0.

Haas J, Barb I, Katus HA, Meder B. Targeted next-generation sequencing: the clinician’s stethoscope for genetic disorders. Personalized Medicine, Vol. 11, No. 6, Pages 581-592.

Li J, Franke J, Pribe-Wolferts R, Meder B, Ehlermann P, Mereles D, Andre F, Abdelrazek MA, Merten C, Schweizer PA, Becker R, Katus HA, Thomas D. Effects of β-blocker therapy on electrocardiographic and echocardiographic characteristics of left ventricular noncompaction. Clin Res Cardiol. 2014 Oct 21.

Buss SJ, Breuninger K, Lehrke S, Voss A, Galuschky C, Lossnitzer D, Andre F, Ehlermann P, Franke J, Taeger T, Frankenstein L, Steen H, Meder B, Giannitsis E, Katus HA, Korosoglou G. Assessment of myocardial deformation with cardiac magnetic resonance strain imaging improves risk stratification in patients with dilated cardiomyopathy. Eur Heart J Cardiovasc Imaging. 2014 Sep 21.

Schweizer PA, Schröter J, Greiner S, Haas J, Yampolsky P, Mereles D, Buss SJ, Seyler C, Bruehl C, Draguhn A, Koenen M, Meder B, Katus HA, Thomas D. The Symptom Complex of Familial Sinus Node Dysfunction and Myocardial Noncompaction Is Associated With Mutations in the HCN4 Channel. J Am Coll Cardiol. 2014 Aug 26;64(8):757-67. doi: 10.1016/j.jacc.2014.06.1155.

Haas J, Frese KS, Peil B, Kloos W, Keller A, Nietsch R, Feng Z, Müller S, Kayvanpour E, Vogel B, Sedaghat-Hamedani F, Lim WK, Zhao X, Fradkin D, Köhler D, Fischer S, Franke J, Marquart S, Barb I, Li DT, Amr A, Ehlermann P, Mereles D, Weis T, Hassel S, Kremer A, King V, Wirsz E, Isnard R, Komajda M, Serio A, Grasso M, Syrris P, Wicks E, Plagnol V, Lopes L, Gadgaard T, Eiskjær H, Jørgensen M, Garcia-Giustiniani D, Ortiz-Genga M, Crespo-Leiro MG, Deprez RH, Christiaans I, van Rijsingen IA, Wilde AA, Waldenstrom A, Bolognesi M, Bellazzi R, Mörner S, Bermejo JL, Monserrat L, Villard E, Mogensen J, Pinto YM, Charron P, Elliott P, Arbustini E, Katus HA, Meder B. Atlas of the clinical genetics of human dilated cardiomyopathy. Eur Heart J. 2014 Aug 27. pii: ehu301. [Epub ahead of print]

Zettinig O, Mansi T, Georgescu B, Kayvanpour E, Sedaghat-Hamedani F, Amr A, Haas J, Steen H, Meder B, Katus H, Navab N, Kamen A, Comaniciul D. Fast data-driven calibration of a cardiac electrophysiology model from images and ECG. Med Image Comput Comput Assist Interv. 2013;16(Pt 1):1-8

Thanaraj A, Meder B. Genetic testing is superior to biopsy of the myocardium in cardiomyopathy - yes. Dtsch Med Wochenschr. 2013 Mar;138(12):598. Epub 2013 Mar 12.

Meder B, Rühle F, Weis T, Homuth G, Keller A, Franke J, Peil B, Lorenzo Bermejo J, Frese K, Huge A, Witten A, Vogel B, Haas J, Völker U, Ernst F, Teumer A, Ehlermann P, Zugck C, Friedrichs F, Kroemer H, Dörr M, Hoffmann W, Maisch B, Pankuweit S, Ruppert V, Scheffold T, Kühl U, Schultheiss HP, Kreutz R, Ertl G, Angermann C, Charron P, Villard E, Gary F, Isnard R, Komajda M, Lutz M, Meitinger T, Sinner MF, Wichmann HE, Krawczak M, Ivandic B, Weichenhan D, Gelbrich G, El-Mokhtari NE, Schreiber S, Felix SB, Hasenfuß G, Pfeufer A, Hübner N, Kääb S, Arbustini E, Rottbauer W, Frey N, Stoll M, Katus HA. A genome-wide association study identifies 6p21 as novel risk locus for dilated cardiomyopathy. Eur Heart J. 2014 Apr;35(16):1069-77. doi: 10.1093/eurheartj/eht251. Epub 2013 Jul 12.

Haas J, Frese KS, Park YJ, Keller A, Vogel B, Lindroth AM, Weichenhan D, Franke J, Fischer S, Bauer A, Marquart S, Sedaghat-Hamedani F, Kayvanpour E, Köhler D, Wolf NM, Hassel S, Nietsch R, Wieland T, Ehlermann P, Schultz JH, Dösch A, Mereles D, Hardt S, Backs J, Hoheisel JD, Plass C, Katus HA, Meder B. Alterations in cardiac DNA methylation in human dilated cardiomyopathy. EMBO Mol Med. 2013 Jan 22. doi: 10.1002/emmm.201201553.

Narula N, Favalli V, Tarantino P, Grasso M, Pilotto A, Bellazzi R, Serio A, Gambarin FI, Charron P, Meder B, Pinto Y, Elliott PM, Mogensen J, Bolognesi M, Bollati M, Arbustini E. Quantitative Expression of the Mutated Lamin A/C Gene in Patients With Cardiolaminopathy. J Am Coll Cardiol. 2012 Sep 28. pii: S0735-1097(12)04113-7.

Meder B, Frese KS, Katus HA. Die dilatative Kardiomyopathie – Ein Update. Aktuelle Kardiologie. 2012

Kloos W, Katus HA, Meder B. Genetic cardiomyopathies: Lessons learned from humans, mice, and zebrafish. Herz. 2012 Jul 7.

Meder B, Katus HA. Clinical and genetic aspects of hypertrophic and dilated cardiomyopathy. Der Internist 2012

Ehlermann P, Lehrke S, Papavassiliu T, Meder B, Borggrefe M, Katus HA, Schimpf R. Sudden cardiac death in a patient with lamin A/C mutation in the absence of dilated cardiomyopathy or conduction disease. Clin Res Cardiol. 2011 Feb 16.

Meder B. MicroRNA Signaturen als neue Biomarker kardiovaskulärer Erkrankungen - Winzige Moleküle zeigen Herzinfarkt an. Lebendige Wissenschaft – Spitzenforschung Herz-Kreislauf-Medizin 2011

Meder B, Haas J, Keller A, Heid C, Just S, Borries A, Boisguerin V, Scharfenberger-Schmeer M, Stähler P, Beier M, Weichenhan D, Strom T, Pfeufer A, Korn B, Katus HA, Rottbauer W. Targeted Next-Generation Sequencing for the Molecular Genetic Diagnostics of Cardiomyopathies. Circulation Cardiovascular Genetics 2011 (epub ahead of print)

Vogel B*, Meder B*, Just S, Laufer C, Berger I, Weber S, Katus HA, Rottbauer W. In Vivo Characterization of Human Dilated Cardiomyopathy Genes in Zebrafish. Biochem. Biophys. Res. Commun. 2009, doi:10.1016/j.bbrc.2009.09.129 (*contributed equally)

Meder B, Katus HA, Rottbauer W. Leichte Kette mit schweren Folgen - Der Zebrafish als Modell genetischer Herzschwäche. GenomXpress 2009;3.09

Meder B, Katus HA, Rottbauer, W. Genetik der hypertrophischen Kardiomyopathie. Journal für Kardiologie 2009;16 (7-8), 274-278