Hüttner FJ, Klotz R, Giese NA, Kong B, Ahmed A, Merz D, Pöchmann A, Burghaus I, Hackert T, Strobel O, Mihaljevic AL, Michalski CW, Büchler MW, Diener MK.
Pancreatic resection with perioperative drug repurposing of propranolol and etodolac - the phase II randomized controlled PROSPER trial.
Langenbecks Arch Surg. 2025 May 22;410(1):168. PMID: 40402347. 

Pausch TM, Holze M, El-Mahdy J, Gesslein B, Thedius HO, Sander A, Tenckhoff S, Sundermann T, Larmann J, Probst P, Pianka F, Klotz R, Hackert T.
Visualization of Intraoperative Pancreatic Leakage (ViP): The IDEAL Stage I First-in-human, Single-arm Clinical Pilot Trial of SmartPAN. 
Ann Surg Open. 2025 Mar 11;6(1):e529. PMID: 40134475.

Kaiser J, Niesen W, Hinz U, Diener MK, Pianka F, Klotz R, Strobel O, Mehrabi A, Berchtold C, Müller B, Schneider M, Loos M, Michalski C, Büchler MW, Hackert T, Probst P.
Reconsidering Abdominal Drainage After Left Pancreatectomy - The Randomized Controlled PANDRA II Trial.
Ann Surg. 2025 Feb 5. PMID: 39907004.

Hüttner FJ, Probst P, Mihaljevic AL, Sauer LD, Doerr-Harim C, Ulrich A, Stratmeyer S, Klotz R, Diener MK, Knebel P.
Ghost-ileostomy versus conventional loop ileostomy in patients undergoing low anterior resection for rectal cancer: results of a randomised controlled multicentre pilot trial (DRKS00013997). 
Langenbecks Arch Surg. 2024 Nov 9;409(1):341. PMID: 39520543. 

Heger P, Diener MK, Feißt M, Gaida MM, Klose C, Knebel P, Klotz R, Dörr-Harim C, Mihaljevic AL.
Conventional  partial pancreatoduodenectomy versus an uncinate first, extended partial pancreatoduodenectomy approach for  the resection of pancreatic head cancer: the randomized, controlled PancER trial.
Innov Surg Sci 2024.

Schuh F, Yildirim B, Klotz R, Pianka F, Boskovic A, Werba A, Fink MA, Wild C, Schwab C, Eckert C, Feisst M, Mihaljevic AL, Loos M, Büchler M, Probst P.
Prospective Validation of the Pancreatic Fistula Risk Classification by the International Study Group for Pancreatic Surgery (PARIS trial). 
Ann Surg. 2024 Aug 8. PMID: 39114920. 

Mueller TC, Kehl V, Dimpel R, Blankenstein C, Egert-Schwender S, Strudthoff J, Lock JF, Wiegering A, Hadian A, Lang H, Albertsmeier M, Neuberger M, Von Ehrlich-Treuenstätt V, Mihaljevic AL, Knebel P, Pianka F, Braumann C, Uhl W, Bouchard R, Petrova E, Bork U, Distler M, Tachezy M, Izbicki JR, Reissfelder C, Herrle F, Vay C, Knoefel WT, Buia A, Hanisch E, Friess H, Reim D; IOWISI Study Group.
Intraoperative Wound Irrigation for the Prevention of Surgical Site Infection After Laparotomy: A Randomized Clinical Trial by CHIR-Net. 
JAMA Surg. 2024 May 1;159(5):484-492.

Klotz R, Mihaljevic AL, Kulu Y, Sander A, Klose C, Behnisch R, Joos MC, Kalkum E, Nickel F, Knebel P, Pianka F, Diener MK, Büchler MW, Hackert T.
Robotic versus open partial pancreatoduodenectomy (EUROPA): a randomised controlled stage 2b trial.
The Lancet Regional Health - Europe. Volume 39, April 2024, 100864.

Rahbari NN, Biondo S, Frago R, Feißt M, Kreisler E, Rossion I, Serrano M, Jäger D, Lehmann M, Sommer F, Dignass A, Bolling C, Vogel I, Bork U, Büchler MW, Folprecht G, Kieser M, Lordick F, Weitz J; SYNCHRONOUS and CCRe-IV Trial Groups. 
Primary Tumor Resection Before Systemic Therapy in Patients With Colon Cancer and Unresectable Metastases: Combined Results of the SYNCHRONOUS and CCRe-IV Trials 
J Clin Oncol. 2024 May 1;42(13):1531-1541. Epub 2024 Feb 27.

Klotz R, Ahmed A, Tremmel A, Büsch C, Tenckhoff S, Doerr-Harim C, Lock JF, Brede EM, Köninger J, Schiff JH, Wittel UA, Hötzel A, Keck T, Nau C, Amati AL, Koch C, Diener MK, Weigand MA, Büchler MW, Knebel P, Larmann J.
Thoracic Epidural Analgesia Is Not Associated With Improved Survival After Pancreatic Surgery: Long-Term Follow-Up of the Randomized Controlled PAKMAN Trial. 
Anesth Analg. 2024 Feb 9. PMID: 38335141.

Van den Dop LM, Sneiders D, Yurtkap Y, Werba A, van Klaveren D, Pierik REGJM, Reim D, Timmermans L, Fortelny RH, Mihaljevic AL, Kleinrensink GJ, Tanis PJ, Lange JF, Jeekel J; PRIMA Trialist Group.
Prevention of incisional hernia with prophylactic onlay and sublay mesh reinforcement vs. primary suture only in midline laparotomies (PRIMA): long-term outcomes of a multicentre, double-blind, randomised controlled trial.
Lancet Reg Health Eur. 2023 Nov 22;36:100787. PMID: 38188275.

Brandenburg JM, Jenke AC, Stern A, Daum MTJ, Schulze A, Younis R, Petrynowski P, Davitashvili T, Vanat V, Bhasker N, Schneider S, Mündermann L, Reinke A, Kolbinger FR, Jörns V, Fritz-Kebede F, Dugas M, Maier-Hein L, Klotz R, Distler M, Weitz J, Müller-Stich BP, Speidel S, Bodenstedt S, Wagner M.
Active learning for extracting surgomic features in robot-assisted minimally invasive esophagectomy: a prospective annotation study. 
Surg Endosc. 2023 Nov;37(11):8577-8593. Epub 2023 Oct 14.

Polychronidis G, Rahbari NN, Bruckner T, Sander A, Sommer F, Usta S, Hermann J, Albers MB, Sargut M, Knebel P, Klotz R.
Continuous versus interrupted abdominal wall closure after emergency midline laparotomy: CONTINT: a randomized controlled trial [NCT00544583].
World J Emerg Surg. 2023 Oct 17;18(1):51. PMID: 37848901.

CHIR-Net SIGMA Study Group*, Mihaljevic AL. Multicenter Prospective Cohort Study of the Patient-Reported Outcome Measures PRO-CTCAE and CAT EORTC QLQ-C30 in Major Abdominal Cancer Surgery (PATRONUS): A Student-Initiated German Medical Audit (SIGMA) Study. 
Ann Surg Oncol. 2021 Jun;28(6):3075-3089.

Klotz R, Larmann J, Klose C, Bruckner T, Benner L, Doerr-Harim C, Tenckhoff S, Lock JF, Brede EM, Salvia R, Polati E, Köninger J, Schiff JH, Wittel UA, Hötzel A, Keck T, Nau C, Amati AL, Koch C, Eberl T, Zink M, Tomazic A, Novak-Jankovic V, Hofer S, Diener MK, Weigand MA, Büchler MW, Knebel P; PAKMAN Trial Group.
Gastrointestinal Complications After Pancreatoduodenectomy With Epidural vs Patient-Controlled Intravenous Analgesia: A Randomized Clinical Trial.
JAMA Surg. 2020 May 27:e200794.

Hüttner FJ, Bruckner T, Hackbusch M, Weitz J, Bork U, Kotschenreuther P, Heupel O, Kümmel S, Schlitt HJ, Mattulat M, Pintér L, Seiler CM, Gutt CN, Nottberg HS, Pohl A, Ghanem F, Meyer T, Imdahl A, Neudecker J, Müller VA, Gehrig T, Reineke M, von Frankenberg M, Schumacher G, Hennes R, Mihaljevic AL, Rossion I, Klose C, Kieser M, Büchler MW, Diener MK, Knebel P.
Primary Open Versus Closed Implantation Strategy for Totally Implantable Venous Access Ports: The Multicentre Randomized Controlled PORTAS-3 Trial (DRKS 00004900).
Ann Surg. 2019 Nov 27.

Diener MK, Hüttner FJ, Kieser M, Knebel P, Dörr-Harim C, Distler M, Grützmann R, Wittel UA, Schirren R, Hau HM, Kleespies A, Heidecke CD, Tomazic A, Halloran CM, Wilhelm TJ, Bahra M, Beckurts T, Börner T, Glanemann M18, Steger U, Treitschke F, Staib L, Thelen K, Bruckner T, Mihaljevic AL, Werner J, Ulrich A, Hackert T, Büchler MW; ChroPac Trial Group.
Partial pancreatoduodenectomy versus duodenum-preserving pancreatic head resection in chronic pancreatitis: the multicentre, randomised, controlled, double-blind ChroPac trial.
Lancet. 2017 Sep 9;390(10099):1027-1037.

Jairam AP, Timmermans L, Eker HH, Pierik REGJM, van Klaveren D, Steyerberg EW, Timman R, van der Ham AC, Dawson I, Charbon JA, Schuhmacher C, Mihaljevic A, Izbicki JR, Fikatas P, Knebel P, Fortelny RH, Kleinrensink GJ, Lange JF, Jeekel HJ; PRIMA Trialist Group.
Prevention of incisional hernia with prophylactic onlay and sublay mesh reinforcement versus primary suture only in midline laparotomies (PRIMA): 2-year follow-up of a multicentre, double-blind, randomised controlled trial.
Lancet. 2017 Aug 5;390(10094):567-576. Epub 2017 Jun 20.

Schlosser K, Bartsch DK, Diener MK, Seiler CM, Bruckner T, Nies C, Meyer M, Neudecker J, Goretzki PE, Glockzin G, Konopke R, Rothmund M.
Total Parathyroidectomy With Routine Thymectomy and Autotransplantation Versus Total Parathyroidectomy Alone for Secondary Hyperparathyroidism - Results of a Nonconfirmatory Multicenter Prospective Randomized Controlled Pilot Trial.
Ann Surg. 2016 Nov;264(5):745-753. 

Witzigmann H, Diener MK, Kißenkötter S, Rossion I, Bruckner T, Bärbel Werner, Pridöhl O, Radulova-Mauersberger O, Lauer H, Knebel P, Ulrich A, Strobel O, Hackert T, Büchler MW.
No Need for Routine Drainage After Pancreatic Head Resection: The Dual-Center, Randomized, Controlled PANDRA Trial (ISRCTN04937707).
Ann Surg. 2016 Sep;264(3):528-37. 

Keck T, Wellner UF, Bahra M, Klein F, Sick O, Niedergethmann M, Wilhelm TJ, Farkas SA, Börner T, Bruns C, Kleespies A, Kleeff J, Mihaljevic AL, Uhl W, Chromik A, Fendrich V, Heeger K, Padberg W, Hecker A, Neumann UP, Junge K, Kalff JC, Glowka TR, Werner J, Knebel P, Piso P, Mayr M, Izbicki J, Vashist Y, Bronsert P, Bruckner T, Limprecht R, Diener MK, Rossion I, Wegener I, Hopt UT.
Pancreatogastrostomy Versus Pancreatojejunostomy for RECOnstruction After PANCreatoduodenectomy (RECOPANC, DRKS 00000767): Perioperative and Long-term Results of a Multicenter Randomized Controlled Trial.
Ann Surg. 2015 Jul 1. PMID:  26135690

Bartl C, Stengel D, Bruckner T, Gebhard F; ORCHID Study Group
The treatment of displaced intra-articular distal radius fractures in elderly patients.
Dtsch Arztebl Int. 2014 Nov 14;111(46):779-87.

Diener MK, Knebel P, Kieser M, Probst P, Büchler MW.
Antibiotic sutures against surgical site infections–Authors' reply.
The Lancet 384;9952 (2014): 1425-1426.

Büchler MW, Diener MK.
Authors' reply: Incisional hernia rate 3 years after midline laparotomy (Br J Surg 2014; 101: 51-54).
Br J Surg. 2014 Jul;101(8):1032-3.

Diener MK, Knebel P, Kieser M, Schüler P, Schiergens TS, Atanassov V, Neudecker J, Stein E, Thielemann H, Kunz R, von Frankenberg M, Schernikau U, Bunse J, Jansen-Winkeln B, Partecke LI, Prechtl G, Pochhammer J, Bouchard R, Hodina R, Beckurts KT, Leißner L, Lemmens HP, Kallinowski F, Thomusch O, Seehofer D, Simon T, Hyhlik-Dürr A, Seiler CM, Hackert T, Reissfelder C, Hennig R,
Doerr-Harim C, Klose C, Ulrich A, Büchler MW.
Effectiveness of triclosan-coated PDS Plus versus uncoated PDS II sutures for prevention of surgical site infection after abdominal wall closure: the randomised controlled PROUD trial. 
Lancet. 2014 Apr 4. 

Fink C, Baumann P, Wente MN, Knebel P, Bruckner T, Ulrich A, Werner J, Büchler MW,
Diener MK.
Incisional hernia rate 3 years after midline laparotomy.
Br J Surg. 2014 Jan;101(2):51-4.

Löffler T, Rossion I, Bruckner T, Diener MK, Weitz J et al; HASTA Trial Group.
HAnd Suture versus STApling for Closure of Loop Ileostomy (HASTA Trial): results of a multicenter randomized trial (DRKS00000040).
Ann Surg. 2012 Nov;256(5):828-35; discussion 835-6.

Diener MK, Seiler CM, von Frankenberg M, Rendel K, Schüle S, Maschuw K, Riedl
S, Rückert JC, Eckmann C, Scharlau U, Ulrich A, Bruckner T, Knaebel HP, Rothmund
M, Büchler MW; for the CLIVIT Study Group.
Vascular clips versus ligatures in thyroid surgery-results of a multicenter randomized controlled trial (CLIVIT Trial).
Langenbecks Arch Surg. 2012 Oct;397(7):1117-1126.

Fischer L, Knaebel HP, Golcher H, Bruckner T, Diener MK, Bachmann J, Buchler MW, Seiler CM.
To whom do the results of the multicenter, randomized, controlled INSECT trial (ISRCTN 24023541) apply? - Assessment of external validity.
BMC Surg. 2012 Feb 8;12:2.

Fischer L, Deckert A, Diener MK, Zimmermann JB, Büchler MW, Seiler CM.
Ranking of patient and surgeons' perspectives for endpoints in randomized ontrolled trials--lessons learned from the POVATI trial [ISRCTN 60734227].
Langenbecks Arch Surg. 2011 Oct;396(7):1061-6.

Diener MK, Seiler CM, Rossion I, Kleeff J, Glanemann M, Butturini G, Tomazic A, Bruns CJ, Busch OR, Farkas S, Belyaev O, Neoptolemos JP, Halloran C, Keck T, Niedergethmann M, Gellert K, Witzigmann H, Kollmar O, Langer P, Steger U, Neudecker J, Berrevoet F, Ganzera S, Heiss MM, Luntz SP, Bruckner T, Kieser M, Büchler MW.
Efficacy of stapler versus hand-sewn closure after distal pancreatectomy (DISPACT): a randomised, controlled multicentre trial.
Lancet. 2011 Apr 30;337(9776):1514-22.

Seiler CM, Bruckner T, Diener MK, Büchler MW.
Response to the Letter to the Editor: "Suture Materials and Techniques for Midline Abdominal Closure" by Dr. Tetsuji Fujita.
Ann Surg. 2009 Oct;250(4):656; author reply 656-7.

Bruns H, Rahbari NN, Löffler T, Diener MK, Seiler CM, Glanemann M, Butturini G, Schuhmacher C, Rossion I, Büchler MW, Junghans T, DISPACT Trial Group.
Perioperative management in distal pancreatectomy: results of a survey in 23 European participating centres of the DISPACT trial and a review of literature.
Trials. 2009 Jul 26;10:58.

Seiler CM, Deckert A, Diener MK, Knaebel HP, Weigand MA, Victor N, Büchler MW.
Midline versus transverse incision in major abdominal surgery: a randomized, double-blind equivalance trial (POVATI: ISRCTN60734227).
Ann Surg. 2009 Jun;249(6):913-20.

Seiler CM, Bruckner T, Diener MK, Papyan A, Golcher H, Seidlmayer C, Franck A, Kieser M, Büchler MW, Knaebel HP.
Interrupted or Continuous Slowly Absorbable Sutures for Closure of Primary Elective Midline Abdominal Incisions: A Multicenter Randomized Trial (INSECT: ISRCTN24023541).
Ann Surg. 2009 Apr;249(4):576-82.

Seiler CM, Kellmeyer P, Kienle P, Buchler MW, Knaebel HP, the INSECT Study Group.
Assessment of the ethical review process for non-pharmalogical multicentre studies in Germany on the basis of a randomised surgical trial.
J Med Ethics. 2007 Feb;33(2):113-8.

Chung CH, Freiberger A, Kalkum M, Luntz SP, Shakur H, Seiler CM.
CRASH2 in Germany [ISRCTN 86750102].
Trials. 2006 Jun 21;7:22.

Knaebel HP, Kirschner MH, Reidel MA, Büchler MW, Seiler CM.
Operative standardization in randomized controlled surgical trials. Meeting of the INSECT trial.
Chirurg. 2006 Mar;77(3):267-72.