Kliniken & Institute … Kliniken Zentrum für Innere… Internal Medicine III:… Research Molecular… Publications

Publications

2020

Relationship Between Cardiac Fibroblast Activation Protein Activity by Positron Emission Tomography and Cardiovascular Disease. Heckmann MB, Reinhardt F, Finke D, Katus HA, Haberkorn U, Leuschner F, Lehmann LH. Circ Cardiovasc Imaging. 2020 Sep;13(9):e010628. doi: 10.1161/CIRCIMAGING.120.010628. Epub 2020 Sep 11.

A Minimal-Invasive Approach for Standardized Induction of Myocardial Infarction in Mice. Sicklinger F, Zhang Y, Lavine K, Simon N, Bucher V, Jugold M, Lehmann L, Konstandin MH, Katus HA, Leuschner F. Circ Res. 2020 Aug 28. doi: 10.1161/CIRCRESAHA.120.317794.

Establishing an oncocardiology service. Lehmann LH, Totzeck M. Herz. 2020 Jun 22:1-6. doi: 10.1007/s00059-020-04952-w

Emerging role of immune checkpoint inhibitors and their relevance for the cardiovascular system. Michel L, Totzeck M, Lehmann L, Finke D. Herz. 2020 Jun 12. doi: 10.1007/s00059-020-04954-8

Onco-Cardiology: Consensus Paper of the German Cardiac Society, the German Society for Pediatric Cardiology and Congenital Heart Defects and the German Society for Hematology and Medical Oncology. Rassaf T, Totzeck M, Backs J, Bokemeyer C, Hallek M, Hilfiker-Kleiner D, Hochhaus A, Lüftner D, Müller OJ, Neudorf U, Pfister R, von Haehling S, Lehmann LH*, Bauersachs J*; Committee for Clinical Cardiovascular Medicine of the German Cardiac Society. Clin Res Cardiol. 2020 May 13. doi: 10.1007/s00392-020-01636-7. *equally contributed

Heart-Specific Immune Responses in an Animal Model of Autoimmune-Related Myocarditis Mitigated by an Immunoproteasome Inhibitor and Genetic Ablation. Bockstahler M, Fischer A, Goetzke CC, Neumaier HL, Sauter M, Kespohl M, Müller AM, Meckes C, Salbach C, Schenk M, Heuser A, Landmesser U, Weiner J, Meder B, Lehmann L, Kratzer A, Klingel K, Katus HA, Kaya Z, Beling A. Circulation. 2020 Jun 9;141(23):1885-1902. doi: 10.1161/CIRCULATIONAHA.119.043171.

2019

The lipid droplet-associated protein ABHD5 protects the heart through proteolysis of HDAC4. Jebessa ZH, Shanmukha Kumar D, Dewenter M, Lehmann LH, Xu C, Schreiter F, Siede D, Gong XM, Worst BC, Federico G, Sauer SW, Fischer T, Wechselberger L, Müller OJ, Sossalla S, Dieterich C, Most P, Gröne HJ, Moro C, Oberer M, Haemmerle G, Katus HA, Tyedmers J, Backs J. Nat Metab. 2019 Nov;1(11):1157-1167. doi: 10.1038/s42255-019-0138-4.

CaM kinase II regulates cardiac hemoglobin expression through histone phosphorylation upon sympathetic activation. Saadatmand AR, Sramek V, Weber S, Finke D, Dewenter M, Sticht C, Gretz N, Wüstemann T, Hagenmueller M, Kuenzel SR, Meyer-Roxlau S, Kramer M, Sossalla S, Lehmann LH, Kämmerer S, Backs J, El-Armouche A. Proc Natl Acad Sci U S A. 2019 Oct 29;116(44):22282-22287. doi: 10.1073/pnas.1816521116.

[Cardiac arrhythmias in oncological diseases, during radiotherapy, chemotherapy]. Lehmann LH, Katus HA, Scholz EP. Herzschrittmacherther Elektrophysiol. 2019 Sep;30(3):268-273. doi: 10.1007/s00399-019-00634-1.

Evidence for a cardiac metabolic switch in patients with Hodgkin’s lymphoma. Heckmann MB, Totakhel B, Finke D, Anker MS, Müller-Tidow C, Haberkorn U, Katus HA, Lehmann LH. ESC Heart Fail. 2019 Aug;6(4):824-829. doi: 10.1002/ehf2.12475. Epub 2019 Jul 6.

O-GlcNAcylation of Histone Deacetylase 4 Protects the Diabetic Heart From Failure. Kronlage M, Dewenter M, Grosso J, Fleming T, Oehl U, Lehmann LH, Falcão-Pires I, Leite-Moreira AF, Volk N, Gröne HJ, Müller OJ, Sickmann A, Katus HA, Backs J. Circulation. 2019 Aug 13;140(7):580-594. doi: 10.1161/CIRCULATIONAHA.117.031942.

CaMKII activation participates in doxorubicin cardiotoxicity and is attenuated by moderate GRP78 overexpression. Tscheschner H, Meinhardt E, Schlegel P, Jungmann A, Lehmann LH, Müller OJ, Most P, Katus HA, Raake PW. PLoS One. 2019 Apr 29;14(4):e0215992. doi: 10.1371/journal.pone.0215992.

Myofilament Ca2+ sensitivity correlates with left ventricular contractility during the progression of pressure overload-induced left ventricular myocardial hypertrophy in rats. Ruppert M, Bódi B, Korkmaz-Icöz S, Loganathan S, Jiang W, Lehmann L, Oláh A, Barta BA, Sayour AA, Merkely B, Karck M, Papp Z, Szabó G, Radovits T. J Mol Cell Cardiol. 2019 Apr;129:208-218. doi: 10.1016/j.yjmcc.2019.02.017.

Cardiovascular adverse events in multiple myeloma patients. Heckmann MB, Doroudgar S, Katus HA, Lehmann LH. J Thorac Dis. 2018 Dec;10(Suppl 35):S4296-S4305. doi: 10.21037/jtd.2018.09.87.

Experimental ischaemic stroke induces transient cardiac atrophy and dysfunction. Veltkamp R, Uhlmann S, Marinescu M, Sticht C, Finke D, Gretz N, Gröne HJ, Katus HA, Backs J, Lehmann LH. J Cachexia Sarcopenia Muscle. 2019 Feb;10(1):54-62. doi: 10.1002/jcsm.12335.

2018

Enzalutamide in Castration-Resistant Prostate Cancer. Anker MS, Lehmann LH, Anker SD. N Engl J Med. 2018 Oct 4;379(14):1380. doi: 10.1056/NEJMc1810065.

Pressure-volume analysis reveals characteristic sex-related differences in cardiac function in a rat model of aortic banding-induced myocardial hypertrophy. Ruppert M, Korkmaz-Icöz S, Loganathan S, Jiang W, Lehmann L, Oláh A, Sayour AA, Barta BA, Merkely B, Karck M, Radovits T, Szabó G. Am J Physiol Heart Circ Physiol. 2018 Sep 1;315(3):H502-H511. doi: 10.1152/ajpheart.00202.2018.

Cardio-oncology: conflicting priorities of anticancer treatment and cardiovascular outcome. Tilemann LM, Heckmann MB, Katus HA, Lehmann LH, Müller OJ. Clin Res Cardiol. 2018 Apr;107(4):271-280. doi: 10.1007/s00392-018-1202-x.

Inhibition of Endothelial Notch Signaling Impairs Fatty Acid Transport and Leads to Metabolic and Vascular Remodeling of the Adult Heart. Jabs M, Rose AJ, Lehmann LH, Taylor J, Moll I, Sijmonsma TP, Herberich SE, Sauer SW, Poschet G, Federico G, Mogler C, Weis EM, Augustin HG, Yan M, Gretz N, Schmid RM, Adams RH, Gröne HJ, Hell R, Okun JG, Backs J, Nawroth PP, Herzig S, Fischer A. Circulation. 2018 Jun 12;137(24):2592-2608. doi: 10.1161/CIRCULATIONAHA.117.029733.

A proteolytic fragment of histone deacetylase 4 protects the heart from failure by regulating the hexosamine biosynthetic pathway. Lehmann LH, Jebessa ZH, Kreusser MM, Horsch A, He T, Kronlage M, Dewenter M, Sramek V, Oehl U, Krebs-Haupenthal J, von der Lieth AH, Schmidt A, Sun Q, Ritterhoff J, Finke D, Völkers M, Jungmann A, Sauer SW, Thiel C, Nickel A, Kohlhaas M, Schäfer M, Sticht C, Maack C, Gretz N, Wagner M, El-Armouche A, Maier LS, Londoño JEC, Meder B, Freichel M, Gröne HJ, Most P, Müller OJ, Herzig S, Furlong EEM, Katus HA, Backs J. Nat Med. 2018 Jan;24(1):62-72. doi: 10.1038/nm.4452.

2017

Cerebral Microbleeds in Murine Amyloid Angiopathy: Natural Course and Anticoagulant Effects. Marinescu M, Sun L, Fatar M, Neubauer A, Schad L, van Ryn J, Lehmann L, Veltkamp R. Stroke. 2017 Aug;48(8):2248-2254. doi: 10.1161/STROKEAHA.117.017994.

Depletion of cardiac catecholamine stores impairs cardiac norepinephrine re-uptake by downregulation of the norepinephrine transporter. Kreusser MM, Lehmann LH, Haass M, Buss SJ, Katus HA, Lossnitzer D. PLoS One. 2017 Mar 10;12(3):e0172070. doi: 10.1371/journal.pone.0172070.

Nucleoside Diphosphate Kinase-C Suppresses cAMP Formation in Human Heart Failure. Abu-Taha IH, Heijman J, Hippe HJ, Wolf NM, El-Armouche A, Nikolaev VO, Schäfer M, Würtz CM, Neef S, Voigt N, Baczkó I, Varró A, Müller M, Meder B, Katus HA, Spiger K, Vettel C, Lehmann LH, Backs J, Skolnik EY, Lutz S, Dobrev D, Wieland T. Circulation. 2017 Feb 28;135(9):881-897. doi: 10.1161/CIRCULATIONAHA.116.022852.

2016

Inducible cardiomyocyte-specific deletion of CaM kinase II protects from pressure overload-induced heart failure. Kreusser MM, Lehmann LH, Wolf N, Keranov S, Jungmann A, Gröne HJ, Müller OJ, Katus HA, Backs J. Basic Res Cardiol. 2016 Nov;111(6):65. doi: 10.1007/s00395-016-0581-2.

Vorinostat in refractory soft tissue sarcomas – Results of a multi-centre phase II trial of the German Soft Tissue Sarcoma and Bone Tumour Working Group (AIO). Schmitt T, Mayer-Steinacker R, Mayer F, Grünwald V, Schütte J, Hartmann JT, Kasper B, Hüsing J, Hajda J, Ottawa G, Mechtersheimer G, Mikus G, Burhenne J, Lehmann L, Heilig CE, Ho AD, Egerer G. Eur J Cancer. 2016 Sep;64:74-82. doi: 10.1016/j.ejca.2016.05.018.

Oral treatment with a zinc complex of acetylsalicylic acid prevents diabetic cardiomyopathy in a rat model of type-2 diabetes: activation of the Akt pathway. Korkmaz-Icöz S, Al Said S, Radovits T, Li S, Brune M, Hegedűs P, Atmanli A, Ruppert M, Brlecic P, Lehmann LH, Lahrmann B, Grabe N, Yoshikawa Y, Yasui H, Most P, Karck M, Szabó G. Cardiovasc Diabetol. 2016 May 6;15:75. doi: 10.1186/s12933-016-0383-8.

2015

Ataxin-10 is part of a cachexokine cocktail triggering cardiac metabolic dysfunction in cancer cachexia. Schäfer M, Oeing CU, Rohm M, Baysal-Temel E, Lehmann LH, Bauer R, Volz HC, Boutros M, Sohn D, Sticht C, Gretz N, Eichelbaum K, Werner T, Hirt MN, Eschenhagen T, Müller-Decker K, Strobel O, Hackert T, Krijgsveld J, Katus HA, Berriel Diaz M, Backs J, Herzig S. Mol Metab. 2015 Nov 26;5(2):67-78. doi: 10.1016/j.molmet.2015.11.004.

Intercellular communication lessons in heart failure. Bang C, Antoniades C, Antonopoulos AS, Eriksson U, Franssen C, Hamdani N, Lehmann L, Moessinger C, Mongillo M, Muhl L, Speer T, Thum T. Eur J Heart Fail. 2015 Nov;17(11):1091-103. doi: 10.1002/ejhf.399.

Heat-shock-protein 90 protects from downregulation of HIF-1α in calcineurin-induced myocardial hypertrophy. Eschricht S, Jarr KU, Kuhn C, Lehmann L, Kreusser M, Katus HA, Frey N, Chorianopoulos E. J Mol Cell Cardiol. 2015 Aug;85:117-26. doi: 10.1016/j.yjmcc.2015.05.018.

Advanced echocardiography in adult zebrafish reveals delayed recovery of heart function after myocardial cryoinjury. Hein SJ*, Lehmann LH*, Kossack M, Juergensen L, Fuchs D, Katus HA, Hassel D. PLoS One. 2015 Apr 8;10(4):e0122665. doi: 10.1371/journal.pone.0122665. *equally contributed

2014

Essential role of sympathetic endothelin A receptors for adverse cardiac remodeling. Lehmann LH, Rostosky JS, Buss SJ, Kreusser MM, Krebs J, Mier W, Enseleit F, Spiger K, Hardt SE, Wieland T, Haass M, Lüscher TF, Schneider MD, Parlato R, Gröne HJ, Haberkorn U, Yanagisawa M, Katus HA, Backs J. Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13499-504. doi: 10.1073/pnas.1409026111.

CaM Kinase II mediates maladaptive post-infarct remodeling and pro-inflammatory chemoattractant signaling but not acute myocardial ischemia/reperfusion injury. Weinreuter M, Kreusser MM, Beckendorf J, Schreiter FC, Leuschner F, Lehmann LH, Hofmann KP, Rostosky JS, Diemert N, Xu C, Volz HC, Jungmann A, Nickel A, Sticht C, Gretz N, Maack C, Schneider MD, Gröne HJ, Müller OJ, Katus HA, Backs J. EMBO Mol Med. 2014 Oct;6(10):1231-45. doi: 10.15252/emmm.201403848.

Aldosterone augments Na+-induced reduction of cardiac norepinephrine reuptake. Kreusser MM, Lehmann LH, Riffel JH, Haass M, Maser-Gluth C, Backs J, Katus HA, Buss SJ. Am J Physiol Heart Circ Physiol. 2014 Oct 15;307(8):H1169-77. doi: 10.1152/ajpheart.00193.2014.

Cardiac CaM Kinase II genes δ and γ contribute to adverse remodeling but redundantly inhibit calcineurin-induced myocardial hypertrophy. Kreusser MM, Lehmann LH, Keranov S, Hoting MO, Oehl U, Kohlhaas M, Reil JC, Neumann K, Schneider MD, Hill JA, Dobrev D, Maack C, Maier LS, Gröne HJ, Katus HA, Olson EN, Backs J. Circulation. 2014 Oct 7;130(15):1262-73. doi: 10.1161/CIRCULATIONAHA.114.006185.

Rapid and highly efficient inducible cardiac gene knockout in adult mice using AAV-mediated expression of Cre recombinase. Werfel S, Jungmann A, Lehmann L, Ksienzyk J, Bekeredjian R, Kaya Z, Leuchs B, Nordheim A, Backs J, Engelhardt S, Katus HA, Müller OJ. Cardiovasc Res. 2014 Oct 1;104(1):15-23. doi: 10.1093/cvr/cvu174.

Depletion of globosides and isoglobosides fully reverts the morphologic phenotype of Fabry disease. Porubsky S, Jennemann R, Lehmann L, Gröne HJ. Cell Tissue Res. 2014 Oct;358(1):217-27. doi: 10.1007/s00441-014-1922-9.

The role of endothelin-1 in the sympathetic nervous system in the heart. Lehmann LH, Stanmore DA, Backs J. Life Sci. 2014 Nov 24;118(2):165-72. doi: 10.1016/j.lfs.2014.03.005.

Histone deacetylase signaling in cardioprotection. Lehmann LH, Worst BC, Stanmore DA, Backs J. Cell Mol Life Sci. 2014 May;71(9):1673-90. doi: 10.1007/s00018-013-1516-9.

2013

HDAC4 controls histone methylation in response to elevated cardiac load. Hohl M, Wagner M, Reil JC, Müller SA, Tauchnitz M, Zimmer AM, Lehmann LH, Thiel G, Böhm M, Backs J, Maack C. J Clin Invest. 2013 Mar;123(3):1359-70. doi: 10.1172/JCI61084.

Inhibition of apoptosis by the intrinsic but not the extrinsic apoptotic pathway in myocardial ischemia-reperfusion. Kristen AV, Ackermann K, Buss S, Lehmann L, Schnabel PA, Haunstetter A, Katus HA, Hardt SE. Cardiovasc Pathol. 2013 Jul-Aug;22(4):280-6. doi: 10.1016/j.carpath.2013.01.004.

2012

Cardiac remodeling is not modulated by overexpression of muscle LIM protein (MLP). Kuhn C, Frank D, Dierck F, Oehl U, Krebs J, Will R, Lehmann LH, Backs J, Katus HA, Frey N. Basic Res Cardiol. 2012 May;107(3):262. doi: 10.1007/s00395-012-0262-8.

2011

Selective repression of MEF2 activity by PKA-dependent proteolysis of HDAC4. Backs J*, Worst BC*, Lehmann LH*, Patrick DM, Jebessa Z, Kreusser MM, Sun Q, Chen L, Heft C, Katus HA, Olson EN. J Cell Biol. 2011 Oct 31;195(3):403-15. doi: 10.1083/jcb.201105063. *equally contributed

2009

IMAGE CARDIO MED. A patient with LEOPARD syndrome and PTPN11 mutation. Lehmann LH, Schaeufele T, Buss SJ, Balanova M, Hartschuh W, Ehlermann P, Katus HA. Circulation. 2009 Mar 10;119(9):1328-9. doi: 10.1161/CIRCULATIONAHA.108.792861.

The delta isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload. Backs J, Backs T, Neef S, Kreusser MM, Lehmann LH, Patrick DM, Grueter CE, Qi X, Richardson JA, Hill JA, Katus HA, Bassel-Duby R, Maier LS, Olson EN. Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2342-7. doi: 10.1073/pnas.0813013106.

2008

Interstitial pneumonitis with accumulation of intraalveolar macrophages, a facet of amiodarone therapy. Lehmann LH, Weichert W, Schnapauff D, Dietz R, Stockburger M. Clin Res Cardiol. 2008 Dec;97(12):917-20. doi: 10.1007/s00392-008-0706-1.

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