Kliniken &… Kliniken Radiologische… RadioOnkologie und… Forschung GLIO-CAVE-Studie


Adjuvant stereotactic fractionated radiotherapy to the resection cavity in recurrent glioblastomas


  • Unifocal recurrence of a supratentorial glioma
  • HighGrade Glioma at recurrence
  • Prior course of standard treatment (40 – 66 Gy, depending on fractionation concept)
  • Complete resection of all contrast enhancing tumor areas at recurrence
  • age ≥ 18 years of age
  • Karnofsky Performance Score ≥ 60%
  • For women with childbearing potential, (and men) adequate contraception.
  • Ability of subject to understand character and individual consequences of the clinical trial
  • Written informed consent (must be available before enrolment in the trial)


  • Distant multifocal glioblastoma of gliomatosis cerebri
  • Time interval of less than 6 months after primary radiotherapy
  • Previous re-irradiation or prior radiosurgery of prior treatment with interstitial radioactive seeds
  • refusal of the patients to take part in the study
  • Known carcinoma (excluding Carcinoma in situ of the cervix, basal cell carcinoma, squamous cell carcinoma of the skin) requiring immediate treatment interfering with study therapy
  • Pregnant or lactating women
  • Participation in another clinical study or observation period of competing trials, respectively