Kliniken &… Kliniken Zentrum für Innere… Innere Medizin IV:… Forschung AG Dill


Our research group is interested on understanding pathogenetic mechanisms of cholestatic liver diseases, such as primary sclerosing cholangitis, and liver cancer, with a focus on signaling pathways.

Cellular signaling is essential for the intercellular communication within a tissue and between organs and influence all aspects of cellular homeostasis, such as for example growth, differentiation, inflammatory and immune response, and cell death. In disease, signaling pathways are often disturbed and thus contribute to the pathogenic process. The understanding of the underlying molecular mechanisms is essential for the development of new therapeutic approaches in these difficult-to-treat liver diseases.

The laboratory is using primary, patient-based 3D organoid culture methods for a disease-centered research approach. To achieve our aims we combine imaging, molecular biology and biochemistry techniques.

Portrait von Philip Puchas
Dr. med. univ. Philip Puchas

Schwerpunkt: Inflammatory signaling pathways in primary sclerosing cholangitis

Portrait von Farzaneh Kashfi
Farzaneh Kashfi
  • Uniscientia Stiftung
  • Seeding Grant SFB TR 209 (DFG)
  • Seeding Grant TRR 179 (DFG)


Dr. Dr. med. Michael Dill

Leiter Max Eder Nachwuchsgruppe (DKFZ) für Experimentelle Hepatologie, Entzündung und Krebs


Hepatologie, Hepatobiliäre Tumore, Lebertransplantation