B9: Mechanisms of regulation of neurogenesis in the microenvironment of adult brain
There are two regions in the brain where residing neural stem cells (NSCs) continuously give rise to neurons: the subventricular zone (SVZ) and the subgranular zone (SGZ). Understanding how and why neurogenesis is restricted to these regions is going to be the focus of this subproject. Mechanisms involved in adult neurogenesis with a special interest in CD95 and Wnt signals and their mutual interplay, are going to be examined in vitro and in vivo in the naïve and injured brain with the help of various mutant mouse lines. In addition, a translational state array analysis of neural stem cells undergoing neuronal differentiation should help identify novel factors involved in neurogenesis.