2024

Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience. 

Jurgens SJ, Rämö JT, Kramarenko DR, Wijdeveld LFJM, Haas J, Chaffin MD, Garnier S, Gaziano L, Weng LC, Lipov A, Zheng SL, Henry A, Huffman JE, Challa S, Rühle F, Verdugo CD, Krijger Juárez C, Kany S, van Orsouw CA, Biddinger K, Poel E, Elliott AL, Wang X, Francis C, Ruan R, Koyama S, Beekman L, Zimmerman DS, Deleuze JF, Villard E, Trégouët DA, Isnard R; FinnGen; VA Million Veteran Program; HERMES Consortium; Boomsma DI, de Geus EJC, Tadros R, Pinto YM, Wilde AAM, Hottenga JJ, Sinisalo J, Niiranen T, Walsh R, Schmidt AF, Choi SH, Chang KM, Tsao PS, Matthews PM, Ware JS, Lumbers RT, van der Crabben S, Laukkanen J, Palotie A, Amin AS, Charron P, Meder B, Ellinor PT, Daly M, Aragam KG, Bezzina CR. Nat Genet. 2024 Nov 21. doi: 10.1038/s41588-024-01975-5. Online ahead of print. PMID: 39572784 

 

Comparative Effectiveness of Devices for Interventional Patent Foramen Ovale Closure: Insights from a 23-Year Monocentric Analysis. 

Kayvanpour E, Matzeit E, Kaya Z, Pleger S, Bahrmann A, Reichardt C, Ringleb PA, Frey N, Meder B, Sedaghat-Hamedani F. J Clin Med. 2024 Oct 23;13(21):6354. doi: 10.3390/jcm13216354. PMID: 39518493

 

Cardiac troponin elevation and mortality in takotsubo syndrome: New insights from the international takotsubo registry. 

Stähli BE, Schindler M, Schweiger V, Cammann VL, Szawan KA, Niederseer D, Würdinger M, Schönberger A, Schönberger M, Koleva I, Mercier JC, Petkova V, Mayer S, Citro R, Vecchione C, Bossone E, Gili S, Neuhaus M, Franke J, Meder B, Jaguszewski M, Noutsias M, Knorr M, Jansen T, D'Ascenzo F, Dichtl W, von Lewinski D, Burgdorf C, Kherad B, Tschöpe C, Sarcon A, Shinbane J, Rajan L, Michels G, Pfister R, Cuneo A, Jacobshagen C, Karakas M, Koenig W, Pott A, Meyer P, Roffi M, Banning A, Wolfrum M, Cuculi F, Kobza R, Fischer TA, Vasankari T, Airaksinen KEJ, Napp LC, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Chan C, Bridgman P, Beug D, Delmas C, Lairez O, Gilyarova E, Shilova A, Gilyarov M, El-Battrawy I, Akin I, Poledniková K, Toušek P, Winchester DE, Massoomi M, Galuszka J, Ukena C, Poglajen G, Carrilho-Ferreira P, Hauck C, Paolini C, Bilato C, Kobayashi Y, Kato K, Ishibashi I, Himi T, Din J, Al-Shammari A, Prasad A, Rihal CS, Liu K, Schulze PC, Bianco M, Jörg L, Rickli H, Pestana G, Nguyen TH, Böhm M, Maier LS, Pinto FJ, Widimský P, Felix SB, Braun-Dullaeus RC, Rottbauer W, Hasenfuß G, Pieske BM, Schunkert H, Budnik M, Opolski G, Thiele H, Bauersachs J, Horowitz JD, Di Mario C, Kong W, Dalakoti M, Imori Y, Liberale L, Montecucco F, Münzel T, Crea F, Lüscher TF, Bax JJ, Ruschitzka F, Ghadri JR, Di Vece D, Templin C. Eur J Clin Invest. 2024 Dec;54(12):e14317. doi: 10.1111/eci.14317. Epub 2024 Oct 13. PMID: 39397275 

 

A Remote Patient Monitoring System With Feedback Mechanisms Using a Smartwatch: Concept, Implementation, and Evaluation Based on the activeDCM Randomized Controlled Trial. 

Wettstein R, Sedaghat-Hamedani F, Heinze O, Amr A, Reich C, Betz T, Kayvanpour E, Merzweiler A, Büsch C, Mohr I, Friedmann-Bette B, Frey N, Dugas M, Meder B. JMIR Mhealth Uhealth. 2024 Nov 22;12:e58441. doi: 10.2196/58441. PMID: 39365164 Clinical Trial.

 

Improved diagnostic performance of high-sensitivity cardiac troponins in muscle dystrophies using comprehensive definition criteria for cardiac involvement: A longitudinal study on 35 patients. 

Yildirim M, Salbach C, Reich C, Pribe-Wolferts R, Milles BR, Täger T, Mueller-Hennessen M, Weiler M, Meder B, Frey N, Giannitsis E. Eur J Neurol. 2024 Dec;31(12):e16498. doi: 10.1111/ene.16498. Epub 2024 Sep 30. PMID: 39345028 

 

Prognostic Value of Circulating Fibrosis Biomarkers in Dilated Cardiomyopathy (DCM): Insights into Clinical Outcomes. 

Kayvanpour E, Sedaghat-Hamedani F, Li DT, Miersch T, Weis T, Hoefer I, Frey N, Meder B. Biomolecules. 2024 Sep 9;14(9):1137. doi: 10.3390/biom14091137. PMID: 39334904

 

Temporal Trends in Takotsubo Syndrome: Results From the International Takotsubo Registry. 

Schweiger V, Cammann VL, Crisci G, Gilhofer T, Schlenker R, Niederseer D, Chen S, Ebrahimi R, Wenzl F, Würdinger M, Citro R, Vecchione C, Gili S, Neuhaus M, Franke J, Meder B, Jaguszewski M, Noutsias M, Knorr M, Jansen T, D'Ascenzo F, Dichtl W, von Lewinski D, Burgdorf C, Kherad B, Tschöpe C, Sarcon A, Shinbane J, Rajan L, Michels G, Pfister R, Cuneo A, Jacobshagen C, Karakas M, Koenig W, Pott A, Meyer P, Roffi M, Banning A, Wolfrum M, Cuculi F, Kobza R, Fischer TA, Vasankari T, Airaksinen KEJ, Napp LC, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Chan C, Bridgman P, Beug D, Delmas C, Lairez O, Gilyarova E, Shilova A, Gilyarov M, El-Battrawy I, Akin I, Poledniková K, Toušek P, Winchester DE, Massoomi M, Galuszka J, Ukena C, Poglajen G, Carrilho-Ferreira P, Hauck C, Paolini C, Bilato C, Kobayashi Y, Kato K, Ishibashi I, Himi T, Din J, Al-Shammari A, Prasad A, Rihal CS, Liu K, Schulze PC, Bianco M, Jörg L, Rickli H, Pestana G, Nguyen TH, Böhm M, Maier LS, Pinto FJ, Widimský P, Felix SB, Braun-Dullaeus RC, Rottbauer W, Hasenfuß G, Pieske BM, Schunkert H, Budnik M, Opolski G, Thiele H, Bauersachs J, Horowitz JD, Di Mario C, Kong W, Dalakoti M, Imori Y, Münzel T, Liberale L, Montecucco F, Bax JJ, Crea F, Ruschitzka F, Lüscher TF, Ghadri JR, Bossone E, Templin C, Di Vece D. J Am Coll Cardiol. 2024 Sep 24;84(13):1178-1189. doi: 10.1016/j.jacc.2024.05.076. Epub 2024 Sep 1. PMID: 39217551 

 

[Healthcare 4.0-Medicine in transition]. 

Roßkopf S, Meder B. Herz. 2024 Oct;49(5):350-354. doi: 10.1007/s00059-024-05267-w. Epub 2024 Aug 8. PMID: 39115627 Review. German. 

 

Assessing the Applicability of Cardiac Myosin Inhibitors for Hypertrophic Cardiomyopathy Management in a Large Single Center Cohort. 

Amr A, Kayvanpour E, Reich C, Koelemen J, Asokan S, Frey N, Meder B, Sedaghat-Hamedani F. Rev Cardiovasc Med. 2024 Jun 20;25(6):225. doi: 10.31083/j.rcm2506225. eCollection 2024 Jun. PMID: 39076310

 

Personalized care in dilated cardiomyopathy: Rationale and study design of the activeDCM trial. 

Sedaghat-Hamedani F, Amr A, Betz T, Kayvanpour E, Reich C, Wettstein R, Heinze O, Mohr I, Krisam R, Sander A, Klose C, Friedmann-Bette B, Frey N, Meder B. ESC Heart Fail. 2024 Jul 15. doi: 10.1002/ehf2.14970. Online ahead of print.PMID: 39010317 

 

Integrative Analyses of Circulating Proteins and Metabolites Reveal Sex Differences in the Associations with Cardiac Function among DCM Patients. 

Hannemann A, Ameling S, Lehnert K, Dörr M, Felix SB, Nauck M, Al-Noubi MN, Schmidt F, Haas J, Meder B, Völker U, Friedrich N, Hammer E. Int J Mol Sci. 2024 Jun 21;25(13):6827. doi: 10.3390/ijms25136827. PMID: 38999939 

 

Interpretation of elevated baseline concentrations and serial changes of high-sensitivity cardiac troponin T in confirmed muscular dystrophies. 

Yildirim M, Reich C, Salbach C, Pribe-Wolferts R, Milles BR, Täger T, Mueller-Hennessen M, Weiler M, Meder B, Frey N, Giannitsis E. ESC Heart Fail. 2024 Jul 11. doi: 10.1002/ehf2.14864. Online ahead of print. PMID: 38992971 

 

Comparative Assessment of Percutaneous Left-Atrial Appendage Occlusion (LAAO) Devices-A Single Center Cohort Study. 

Kayvanpour E, Kothe M, Kaya Z, Pleger S, Frey N, Meder B, Sedaghat-Hamedani F. J Cardiovasc Dev Dis. 2024 May 21;11(6):158. doi: 10.3390/jcdd11060158. PMID: 38921657

 

Human Genetics of Ebstein Anomaly. 

Sedaghat-Hamedani F, Andelfinger GU, Meder B. Adv Exp Med Biol. 2024;1441:909-914. doi: 10.1007/978-3-031-44087-8_57. PMID: 38884759 Review.

 

Prediction of diagnosis and diastolic filling pressure by AI-enhanced cardiac MRI: a modelling study of hospital data. 

Lehmann DH, Gomes B, Vetter N, Braun O, Amr A, Hilbel T, Müller J, Köthe U, Reich C, Kayvanpour E, Sedaghat-Hamedani F, Meder M, Haas J, Ashley E, Rottbauer W, Felbel D, Bekeredjian R, Mahrholdt H, Keller A, Ong P, Seitz A, Hund H, Geis N, André F, Engelhardt S, Katus HA, Frey N, Heuveline V, Meder B. Lancet Digit Health. 2024 Jun;6(6):e407-e417. doi: 10.1016/S2589-7500(24)00063-3.PMID: 38789141 

 

Prognostic relevance of global work index and global constructive work in patients with non-ischemic dilated cardiomyopathy. 

Chen P, Aurich M, Greiner S, Maliandi G, Müller-Hennessen M, Giannitsis E, Meder B, Frey N, Pleger S, Mereles D. Int J Cardiovasc Imaging. 2024 Jul;40(7):1575-1584. doi: 10.1007/s10554-024-03144-5. Epub 2024 May 23. PMID: 38780712

 

Cardiac biomarkers for diagnosing Takotsubo syndrome. 

Schweiger V, Di Vece D, Cammann VL, Koleva I, Würdinger M, Gilhofer T, Rajman K, Szawan KA, Niederseer D, Citro R, Vecchione C, Bossone E, Gili S, Neuhaus M, Franke J, Meder B, Jaguszewski M, Noutsias M, Knorr M, Jansen T, D'Ascenzo F, Bruno F, De Filippo O, Stefanini G, Campo G, Wanha W, Raposeiras Roubin S, Dichtl W, von Lewinski D, Burgdorf C, Kherad B, Tschöpe C, Sarcon A, Shinbane J, Rajan L, Michels G, Pfister R, Cuneo A, Jacobshagen C, Karakas M, Koenig W, Pott A, Meyer P, Roffi M, Banning A, Wolfrum M, Cuculi F, Kobza R, Fischer TA, Vasankari T, Airaksinen KEJ, Napp LC, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Chan C, Bridgman P, Beug D, Delmas C, Lairez O, Gilyarova E, Shilova A, Gilyarov M, El-Battrawy I, Akin I, Poledniková K, Toušek P, Winchester DE, Massoomi M, Galuszka J, Ukena C, Poglajen G, Carrilho-Ferreira P, Hauck C, Paolini C, Bilato C, Kobayashi Y, Kato K, Ishibashi I, Himi T, Din J, Al-Shammari A, Prasad A, Rihal CS, Liu K, Schulze PC, Bianco M, Jörg L, Rickli H, Pestana G, Nguyen TH, Böhm M, Maier LS, Pinto FJ, Widimský P, Felix SB, Braun-Dullaeus RC, Rottbauer W, Hasenfuß G, Pieske BM, Schunkert H, Budnik M, Opolski G, Thiele H, Bauersachs J, Horowitz JD, Di Mario C, Kong W, Dalakoti M, Imori Y, Münzel T, Bax JJ, Lüscher TF, Crea F, Ruschitzka F, Ghadri JR, Templin C. Eur Heart J. 2024 Jul 9;45(25):2254-2258. doi: 10.1093/eurheartj/ehae231. PMID: 38717630 No abstract available.

 

The role of coronary artery disease in lung transplantation: a propensity-matched analysis. 

Lüsebrink E, Gade N, Seifert P, Ceelen F, Veit T, Fohrer F, Hoffmann S, Höpler J, Binzenhöfer L, Roden D, Saleh I, Lanz H, Michel S, Schneider C, Irlbeck M, Tomasi R, Hatz R, Hausleiter J, Hagl C, Magnussen C, Meder B, Zimmer S, Luedike P, Schäfer A, Orban M, Milger K, Behr J, Massberg S, Kneidinger N. Clin Res Cardiol. 2024 Dec;113(12):1717-1732. doi: 10.1007/s00392-024-02445-y. Epub 2024 Apr 8. PMID: 38587564

 

A contemporary training concept in critical care cardiology. 

Binzenhöfer L, Gade N, Roden D, Saleh I, Lanz H, Sierra LV, Seifert P, Scherer C, Schrage B, Haertel F, Spieth PM, Mangner N, Adler C, Hoyer D, Graf T, Billig H, Salem M, Rangel RH, Speidl WS, Hagl C, Hausleiter J, Massberg S, Preusch M, Meder B, Leistner DM, Luedike P, Rassaf T, Zimmer S, Westermann D, Zeymer U, Schäfer A, Thiele H, Lüsebrink E. Front Cardiovasc Med. 2024 Mar 14;11:1351633. doi: 10.3389/fcvm.2024.1351633. eCollection 2024. PMID: 

 

Scrutinizing the Role of Venoarterial Extracorporeal Membrane Oxygenation: Has Clinical Practice Outpaced the Evidence? 

Lüsebrink E, Binzenhöfer L, Hering D, Villegas Sierra L, Schrage B, Scherer C, Speidl WS, Uribarri A, Sabate M, Noc M, Sandoval E, Erglis A, Pappalardo F, De Roeck F, Tavazzi G, Riera J, Roncon-Albuquerque R Jr, Meder B, Luedike P, Rassaf T, Hausleiter J, Hagl C, Zimmer S, Westermann D, Combes A, Zeymer U, Massberg S, Schäfer A, Orban M, Thiele H. Circulation. 2024 Mar 26;149(13):1033-1052. doi: 10.1161/CIRCULATIONAHA.123.067087. Epub 2024 Mar 25. PMID: 38527130 Review.

 

Cardiomyopathies in children and adolescents: aetiology, management, and outcomes in the European Society of Cardiology EURObservational Research Programme Cardiomyopathy and Myocarditis Registry. 

Kaski JP, Norrish G, Gimeno Blanes JR, Charron P, Elliott P, Tavazzi L, Tendera M, Laroche C, Maggioni AP, Baban A, Khraiche D, Ziolkowska L, Limongelli G, Ojala T, Gorenflo M, Anastasakis A, Mostafa S, Caforio ALP; EORP Paediatric Cardiomyopathy Registry Investigators. Eur Heart J. 2024 Apr 21;45(16):1443-1454. doi: 10.1093/eurheartj/ehae109. PMID: 38427064

 

Generation of an RBM20-mutation-associated left-ventricular non-compaction cardiomyopathy iPSC line (UMGi255-A) into a DCM genetic background to investigate monogenetic cardiomyopathies. 

Eberl H, Rebs S, Hoppe S, Sedaghat-Hamedani F, Kayvanpour E, Meder B, Streckfuss-Bömeke K. Stem Cell Res. 2024 Feb;74:103290. doi: 10.1016/j.scr.2023.103290. Epub 2023 Dec 16. PMID: 38141360 

 

Insulin resistance in Takotsubo syndrome. 

Bruns B, Joos M, Elsous N, Katus HA, Schultz JH, Frey N, Backs J, Meder B. ESC Heart Fail. 2024 Jun;11(3):1515-1524. doi: 10.1002/ehf2.14623. Epub 2023 Dec 20. PMID: 38123355

 

Genetic architecture of cardiac dynamic flow volumes. 

Gomes B, Singh A, O'Sullivan JW, Schnurr TM, Goddard PC, Loong S, Amar D, Hughes JW, Kostur M, Haddad F, Salerno M, Foo R, Montgomery SB, Parikh VN, Meder B, Ashley EA. Nat Genet. 2024 Feb;56(2):245-257. doi: 10.1038/s41588-023-01587-5. Epub 2023 Dec 11. PMID: 38082205 

 

The challenges of research data management in cardiovascular science: a DGK and DZHK position paper-executive summary. 

Steffens S, Schröder K, Krüger M, Maack C, Streckfuss-Bömeke K, Backs J, Backofen R, Baeßler B, Devaux Y, Gilsbach R, Heijman J, Knaus J, Kramann R, Linz D, Lister AL, Maatz H, Maegdefessel L, Mayr M, Meder B, Nussbeck SY, Rog-Zielinska EA, Schulz MH, Sickmann A, Yigit G, Kohl P. Clin Res Cardiol. 2024 May;113(5):672-679. doi: 10.1007/s00392-023-02303-3. Epub 2023 Oct 17. PMID: 37847314 Review.

 

Improving sudden cardiac death risk stratification in hypertrophic cardiomyopathy using established clinical variables and genetic information. 

Amr A, Koelemen J, Reich C, Sedaghat-Hamedani F, Kayvanpour E, Haas J, Frese K, Lehmann D, Katus HA, Frey N, Meder B. Clin Res Cardiol. 2024 May;113(5):728-736. doi: 10.1007/s00392-023-02310-4. Epub 2023 Oct 4. PMID: 37792019

2023

Machine learning-based prediction of in-hospital death for patients with takotsubo syndrome: The InterTAK-ML model. 

De Filippo O, Cammann VL, Pancotti C, Di Vece D, Silverio A, Schweiger V, Niederseer D, Szawan KA, Würdinger M, Koleva I, Dusi V, Bellino M, Vecchione C, Parodi G, Bossone E, Gili S, Neuhaus M, Franke J, Meder B, Jaguszewski M, Noutsias M, Knorr M, Jansen T, Dichtl W, von Lewinski D, Burgdorf C, Kherad B, Tschöpe C, Sarcon A, Shinbane J, Rajan L, Michels G, Pfister R, Cuneo A, Jacobshagen C, Karakas M, Koenig W, Pott A, Meyer P, Roffi M, Banning A, Wolfrum M, Cuculi F, Kobza R, Fischer TA, Vasankari T, Airaksinen KEJ, Napp LC, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Chan C, Bridgman P, Beug D, Delmas C, Lairez O, Gilyarova E, Shilova A, Gilyarov M, El-Battrawy I, Akin I, Poledniková K, Toušek P, Winchester DE, Massoomi M, Galuszka J, Ukena C, Poglajen G, Carrilho-Ferreira P, Hauck C, Paolini C, Bilato C, Kobayashi Y, Kato K, Ishibashi I, Himi T, Din J, Al-Shammari A, Prasad A, Rihal CS, Liu K, Schulze PC, Bianco M, Jörg L, Rickli H, Pestana G, Nguyen TH, Böhm M, Maier LS, Pinto FJ, Widimský P, Felix SB, Braun-Dullaeus RC, Rottbauer W, Hasenfuß G, Pieske BM, Schunkert H, Budnik M, Opolski G, Thiele H, Bauersachs J, Horowitz JD, Di Mario C, Bruno F, Kong W, Dalakoti M, Imori Y, Münzel T, Crea F, Lüscher TF, Bax JJ, Ruschitzka F, De Ferrari GM, Fariselli P, Ghadri JR, Citro R, D'Ascenzo F, Templin C. Eur J Heart Fail. 2023 Dec;25(12):2299-2311. doi: 10.1002/ejhf.2983. Epub 2023 Sep 18. PMID: 37522520

 

Mislocalization of pathogenic RBM20 variants in dilated cardiomyopathy is caused by loss-of-interaction with Transportin-3. 

Kornienko J, Rodríguez-Martínez M, Fenzl K, Hinze F, Schraivogel D, Grosch M, Tunaj B, Lindenhofer D, Schraft L, Kueblbeck M, Smith E, Mao C, Brown E, Owens A, Saguner AM, Meder B, Parikh V, Gotthardt M, Steinmetz LM. Nat Commun. 2023 Jul 18;14(1):4312. doi: 10.1038/s41467-023-39965-6.PMID: 37463913 

 

The Heart and Artificial Intelligence-How Can We Improve Medicine Without Causing Harm. 

Reich C, Meder B. Curr Heart Fail Rep. 2023 Aug;20(4):271-279. doi: 10.1007/s11897-023-00606-0. Epub 2023 Jun 9. PMID: 37291432 Review.

 

Precision medicine in complex diseases-Molecular subgrouping for improved prediction and treatment stratification. 

Johansson Å, Andreassen OA, Brunak S, Franks PW, Hedman H, Loos RJF, Meder B, Melén E, Wheelock CE, Jacobsson B. J Intern Med. 2023 Oct;294(4):378-396. doi: 10.1111/joim.13640. Epub 2023 Apr 24. PMID: 37093654 Review.

 

Indirect epigenetic testing identifies a diagnostic signature of cardiomyocyte DNA methylation in heart failure. 

Oeing CU, Pepin ME, Saul KB, Agircan AS, Assenov Y, Merkel TS, Sedaghat-Hamedani F, Weis T, Meder B, Guan K, Plass C, Weichenhan D, Siede D, Backs J. Basic Res Cardiol. 2023 Mar 20;118(1):9. doi: 10.1007/s00395-022-00954-3.PMID: 36939901

 

The DZHK research platform: maximisation of scientific value by enabling access to health data and biological samples collected in cardiovascular clinical studies. 

Hoffmann J, Hanß S, Kraus M, Schaller J, Schäfer C, Stahl D, Anker SD, Anton G, Bahls T, Blankenberg S, Blumentritt A, Boldt LH, Cordes S, Desch S, Doehner W, Dörr M, Edelmann F, Eitel I, Endres M, Engelhardt S, Erdmann J, Eulenburg K, Falk V, Felix SB, Frank D, Franke T, Frey N, Friede T, Geidel L, Germans L, Grabmaier U, Halle M, Hausleiter J, Jakobi V, Jebran AF, Jobs A, Kääb S, Karakas M, Katus HA, Klatt A, Knosalla C, Krebser J, Landmesser U, Lee M, Lehnert K, Lesser S, Leyh K, Lorbeer R, Mach-Kolb S, Meder B, Nagel E, Nolte CH, Parwani AS, Petersmann A, Puls M, Rau H, Reiser M, Rienhoff O, Scharfe T, Schattschneider M, Scheel H, Schnabel RB, Schuster A, Schmitt B, Seidler T, Seiffert M, Stähli BE, Stas A, J Stocker T, von Stülpnagel L, Thiele H, Wachter R, Wakili R, Weis T, Weitmann K, Wichmann HE, Wild P, Zeller T, Hoffmann W, Zeisberg EM, Zimmermann WH, Krefting D, Kühne T, Peters A, Hasenfuß G, Massberg S, Sommer T, Dimmeler S, Eschenhagen T, Nauck M. Clin Res Cardiol. 2023 Jul;112(7):923-941. doi: 10.1007/s00392-023-02177-5. Epub 2023 Mar 8. PMID: 36884078 

 

Cardiac splicing as a diagnostic and therapeutic target. 

Gotthardt M, Badillo-Lisakowski V, Parikh VN, Ashley E, Furtado M, Carmo-Fonseca M, Schudy S, Meder B, Grosch M, Steinmetz L, Crocini C, Leinwand L. Nat Rev Cardiol. 2023 Aug;20(8):517-530. doi: 10.1038/s41569-022-00828-0. Epub 2023 Jan 18. PMID: 36653465 Review. 

Deep phenotyping of two preclinical mouse models and a cohort of RBM20 mutation carriers reveals no sex-dependent disease severity in RBM20 cardiomyopathy. 

Lennermann DC, Pepin ME, Grosch M, Konrad L, Kemmling E, Hartmann J, Nolte JL, Clauder-Münster S, Kayvanpour E, Sedaghat-Hamedani F, Haas J, Meder B, van den Boogaard M, Amin AS, Dewenter M, Krüger M, Steinmetz LM, Backs J, van den Hoogenhof MMG. Am J Physiol Heart Circ Physiol. 2022 Dec 1;323(6):H1296-H1310. doi: 10.1152/ajpheart.00328.2022. Epub 2022 Nov 11. PMID: 36367695 

            

Genotype Complements the Phenotype: Identification of the Pathogenicity of an LMNA Splice Variant by Nanopore Long-Read Sequencing in a Large DCM Family. 

Sedaghat-Hamedani F, Rebs S, Kayvanpour E, Zhu C, Amr A, Müller M, Haas J, Wu J, Steinmetz LM, Ehlermann P, Streckfuss-Bömeke K, Frey N, Meder B. Int J Mol Sci. 2022 Oct 13;23(20):12230. doi: 10.3390/ijms232012230.PMID: 36293084 

 

NIMA-related kinase 9 regulates the phosphorylation of the essential myosin light chain in the heart. 

Müller M, Eghbalian R, Boeckel JN, Frese KS, Haas J, Kayvanpour E, Sedaghat-Hamedani F, Lackner MK, Tugrul OF, Ruppert T, Tappu R, Martins Bordalo D, Kneuer JM, Piekarek A, Herch S, Schudy S, Keller A, Grammes N, Bischof C, Klinke A, Cardoso-Moreira M, Kaessmann H, Katus HA, Frey N, Steinmetz LM, Meder B. Nat Commun. 2022 Oct 20;13(1):6209. doi: 10.1038/s41467-022-33658-2.PMID: 36266340

 

Natural History of MYH7-Related Dilated Cardiomyopathy. 

de Frutos F, Ochoa JP, Navarro-Peñalver M, Baas A, Bjerre JV, Zorio E, Méndez I, Lorca R, Verdonschot JAJ, García-Granja PE, Bilinska Z, Fatkin D, Fuentes-Cañamero ME, García-Pinilla JM, García-Álvarez MI, Girolami F, Barriales-Villa R, Díez-López C, Lopes LR, Wahbi K, García-Álvarez A, Rodríguez-Sánchez I, Rekondo-Olaetxea J, Rodríguez-Palomares JF, Gallego-Delgado M, Meder B, Kubanek M, Hansen FG, Restrepo-Córdoba MA, Palomino-Doza J, Ruiz-Guerrero L, Sarquella-Brugada G, Perez-Perez AJ, Bermúdez-Jiménez FJ, Ripoll-Vera T, Rasmussen TB, Jansen M, Sabater-Molina M, Elliot PM, Garcia-Pavia P; European Genetic Cardiomyopathies Initiative Investigators. J Am Coll Cardiol. 2022 Oct 11;80(15):1447-1461. doi: 10.1016/j.jacc.2022.07.023. Epub 2022 Aug 22. PMID: 36007715

 

Multi-omics assessment of dilated cardiomyopathy using non-negative matrix factorization. 

Tappu R, Haas J, Lehmann DH, Sedaghat-Hamedani F, Kayvanpour E, Keller A, Katus HA, Frey N, Meder B. PLoS One. 2022 Aug 18;17(8):e0272093. doi: 10.1371/journal.pone.0272093. eCollection 2022. PMID: 35980883

 

Cardiac sarcoidosis: growing evidence in risk stratification. 

Meder B, Koelemen J. Eur Heart J. 2022 Sep 21;43(36):3460-3462. doi: 10.1093/eurheartj/ehac411. PMID: 35920166 No abstract available.

 

VARS2 Depletion Leads to Activation of the Integrated Stress Response and Disruptions in Mitochondrial Fatty Acid Oxidation. 

Kayvanpour E, Wisdom M, Lackner MK, Sedaghat-Hamedani F, Boeckel JN, Müller M, Eghbalian R, Dudek J, Doroudgar S, Maack C, Frey N, Meder B. Int J Mol Sci. 2022 Jun 30;23(13):7327. doi: 10.3390/ijms23137327.PMID: 35806332 

 

Targeted Analysis of circRNA Expression in Patient Samples by Lexo-circSeq. 

Naarmann-de Vries IS, Eschenbach J, Schudy S, Meder B, Dieterich C. Front Mol Biosci. 2022 Jun 8;9:875805. doi: 10.3389/fmolb.2022.875805. eCollection 2022. PMID: 35755822

 

Reduction of A-to-I RNA editing in the failing human heart regulates formation of circular RNAs. 

Kokot KE, Kneuer JM, John D, Rebs S, Möbius-Winkler MN, Erbe S, Müller M, Andritschke M, Gaul S, Sheikh BN, Haas J, Thiele H, Müller OJ, Hille S, Leuschner F, Dimmeler S, Streckfuss-Bömeke K, Meder B, Laufs U, Boeckel JN. Basic Res Cardiol. 2022 Jun 23;117(1):32. doi: 10.1007/s00395-022-00940-9.PMID: 35737129 

2022

Structured, Harmonized, and Interoperable Integration of Clinical Routine Data to Compute Heart Failure Risk Scores. 

Sommer KK, Amr A, Bavendiek U, Beierle F, Brunecker P, Dathe H, Eils J, Ertl M, Fette G, Gietzelt M, Heidecker B, Hellenkamp K, Heuschmann P, Hoos JDE, Kesztyüs T, Kerwagen F, Kindermann A, Krefting D, Landmesser U, Marschollek M, Meder B, Merzweiler A, Prasser F, Pryss R, Richter J, Schneider P, Störk S, Dieterich C. Life (Basel). 2022 May 18;12(5):749. doi: 10.3390/life12050749.PMID: 35629415

 

Doxorubicin induces cardiotoxicity in a pluripotent stem cell model of aggressive B cell lymphoma cancer patients. 

Haupt LP, Rebs S, Maurer W, Hübscher D, Tiburcy M, Pabel S, Maus A, Köhne S, Tappu R, Haas J, Li Y, Sasse A, Santos CCX, Dressel R, Wojnowski L, Bunt G, Möbius W, Shah AM, Meder B, Wollnik B, Sossalla S, Hasenfuss G, Streckfuss-Bömeke K. Basic Res Cardiol. 2022 Mar 8;117(1):13. doi: 10.1007/s00395-022-00918-7.PMID: 35260914

 

Missense Variant E1295K of Sodium Channel SCN5A Associated With Recurrent Ventricular Fibrillation and Myocardial Inflammation.

Poller W, Escher F, Haas J, Heidecker B, Schultheiss HP, Attanasio P, Skurk C, Haghikia A, Meder B, Klaassen S. JACC Case Rep. 2022 Mar 2;4(5):280-286. doi: 10.1016/j.jaccas.2022.01.016. eCollection 2022 Mar 2. PMID: 35257103 

 

Functional Therapeutic Target Validation Using Pediatric Zebrafish Xenograft Models. 

Gatzweiler C, Ridinger J, Herter S, Gerloff XF, ElHarouni D, Berker Y, Imle R, Schmitt L, Kreth S, Stainczyk S, Ayhan S, Najafi S, Krunic D, Frese K, Meder B, Reuss D, Fiesel P, Schramm K, Blattner-Johnson M, Jones DTW, Banito A, Westermann F, Oppermann S, Milde T, Peterziel H, Witt O, Oehme I. Cancers (Basel). 2022 Feb 8;14(3):849. doi: 10.3390/cancers14030849.PMID: 35159116

 

A human cell atlas of the pressure-induced hypertrophic heart. 

Nicin L, Schroeter SM, Glaser SF, Schulze-Brüning R, Pham MD, Hille SS, Yekelchyk M, Kattih B, Abplanalp WT, Tombor L, Müller OJ, Braun T, Meder B, Reich C, Arsalan M, Holubec T, Walther T, Emrich F, Krishnan J, Zeiher AM, John D, Dimmeler S. Nat Cardiovasc Res. 2022 Feb;1(2):174-185. doi: 10.1038/s44161-022-00019-7. Epub 2022 Feb 14. PMID: 39195989

 

Non-invasive imaging as the cornerstone of cardiovascular precision medicine. 

Achenbach S, Fuchs F, Goncalves A, Kaiser-Albers C, Ali ZA, Bengel FM, Dimmeler S, Fayad ZA, Mebazaa A, Meder B, Narula J, Shah A, Sharma S, Voigt JU, Plein S. Eur Heart J Cardiovasc Imaging. 2022 Mar 22;23(4):465-475. doi: 10.1093/ehjci/jeab287. PMID: 35048106 Review. 

2021

Marathon-Induced Cardiac Strain as Model for the Evaluation of Diagnostic microRNAs for Acute Myocardial Infarction. 

Shirvani Samani O, Scherr J, Kayvanpour E, Haas J, Lehmann DH, Gi WT, Frese KS, Nietsch R, Fehlmann T, Sandke S, Weis T, Keller A, Katus HA, Halle M, Frey N, Meder B, Sedaghat-Hamedani F. J Clin Med. 2021 Dec 21;11(1):5. doi: 10.3390/jcm11010005. PMID: 35011745 

 

Expert-enhanced machine learning for cardiac arrhythmia classification. 

Sager S, Bernhardt F, Kehrle F, Merkert M, Potschka A, Meder B, Katus H, Scholz E. PLoS One. 2021 Dec 23;16(12):e0261571. doi: 10.1371/journal.pone.0261571. eCollection 2021. PMID: 34941897

 

Controlling my genome with my smartphone: first clinical experiences of the PROMISE system. 

Amr A, Hinderer M, Griebel L, Deuber D, Egger C, Sedaghat-Hamedani F, Kayvanpour E, Huhn D, Haas J, Frese K, Schweig M, Marnau N, Krämer A, Durand C, Battke F, Prokosch HU, Backes M, Keller A, Schröder D, Katus HA, Frey N, Meder B. Clin Res Cardiol. 2022 Jun;111(6):638-650. doi: 10.1007/s00392-021-01942-8. Epub 2021 Oct 25. PMID: 34694434

 

RBM20-Related Cardiomyopathy: Current Understanding and Future Options. 

Koelemen J, Gotthardt M, Steinmetz LM, Meder B. J Clin Med. 2021 Sep 11;10(18):4101. doi: 10.3390/jcm10184101.PMID: 34575212 Review.

 

An Apple Watch Dashboard for HiGHmed Heart Insufficency Patients. 

Smieszek M, Kindermann A, Amr A, Meder B, Dieterich C. Stud Health Technol Inform. 2021 Sep 21;283:146-155. doi: 10.3233/SHTI210553. PMID: 34545830 

 

Combining APR-246 and HDAC-Inhibitors: A Novel Targeted Treatment Option for Neuroblastoma. 

Müller M, Rösch L, Najafi S, Gatzweiler C, Ridinger J, Gerloff XF, Jones DTW, Baßler J, Kreth S, Stainczyk S, Frese K, Meder B, Westermann F, Milde T, Peterziel H, Witt O, Oehme I. Cancers (Basel). 2021 Sep 5;13(17):4476. doi: 10.3390/cancers13174476. PMID: 34503286

 

Rare Case of Selenite Poisoning Manifesting as Non-ST-Segment Elevation Myocardial Infarction. 

Stroikova V, Regul D, Meder B. JACC Case Rep. 2021 Apr 14;3(5):811-815. doi: 10.1016/j.jaccas.2020.12.051. eCollection 2021 May. PMID: 34317631

 

Impact of Atrial Fibrillation on Outcome in Takotsubo Syndrome: Data From the International Takotsubo Registry. 

El-Battrawy I, Cammann VL, Kato K, Szawan KA, Di Vece D, Rossi A, Wischnewsky M, Hermes-Laufer J, Gili S, Citro R, Bossone E, Neuhaus M, Franke J, Meder B, Jaguszewski M, Noutsias M, Knorr M, Heiner S, D'Ascenzo F, Dichtl W, Burgdorf C, Kherad B, Tschöpe C, Sarcon A, Shinbane J, Rajan L, Michels G, Pfister R, Cuneo A, Jacobshagen C, Karakas M, Koenig W, Pott A, Meyer P, David Arroja J, Banning A, Cuculi F, Kobza R, Fischer TA, Vasankari T, Airaksinen KEJ, Napp LC, Budnik M, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Chan C, Bridgman P, Beug D, Delmas C, Lairez O, Gilyarova E, Shilova A, Gilyarov M, Kozel M, Tousek P, Winchester DE, Galuszka J, Ukena C, Poglajen G, Carrilho-Ferreira P, Hauck C, Paolini C, Bilato C, Kobayashi Y, Prasad A, Rihal CS, Liu K, Schulze PC, Bianco M, Jörg L, Rickli H, Pestana G, Nguyen TH, Böhm M, Maier LS, Pinto FJ, Widimský P, Felix SB, Opolski G, Braun-Dullaeus RC, Rottbauer W, Hasenfuß G, Pieske BM, Schunkert H, Thiele H, Bauersachs J, Katus HA, Horowitz JD, Di Mario C, Münzel T, Crea F, Bax JJ, Lüscher TF, Ruschitzka F, Duru F, Borggrefe M, Ghadri JR, Akin I, Templin C. J Am Heart Assoc. 2021 Aug 3;10(15):e014059. doi: 10.1161/JAHA.119.014059. Epub 2021 Jul 28. PMID: 34315238

 

A genetic variant alters the secondary structure of the lncRNA H19 and is associated with dilated cardiomyopathy. 

Martens L, Rühle F, Witten A, Meder B, Katus HA, Arbustini E, Hasenfuß G, Sinner MF, Kääb S, Pankuweit S, Angermann C, Bornberg-Bauer E, Stoll M. RNA Biol. 2021 Oct 15;18(sup1):409-415. doi: 10.1080/15476286.2021.1952756. Epub 2021 Jul 27. PMID: 34313541

 

SLM2 Is A Novel Cardiac Splicing Factor Involved in Heart Failure due to Dilated Cardiomyopathy. 

Boeckel JN, Möbius-Winkler M, Müller M, Rebs S, Eger N, Schoppe L, Tappu R, Kokot KE, Kneuer JM, Gaul S, Bordalo DM, Lai A, Haas J, Ghanbari M, Drewe-Boss P, Liss M, Katus HA, Ohler U, Gotthardt M, Laufs U, Streckfuss-Bömeke K, Meder B. Genomics Proteomics Bioinformatics. 2022 Feb;20(1):129-146. doi: 10.1016/j.gpb.2021.01.006. Epub 2021 Jul 15. PMID: 34273561

 

A novel risk model for predicting potentially life-threatening arrhythmias in non-ischemic dilated cardiomyopathy (DCM-SVA risk). 

Kayvanpour E, Sammani A, Sedaghat-Hamedani F, Lehmann DH, Broezel A, Koelemenoglu J, Chmielewski P, Curjol A, Socie P, Miersch T, Haas J, Gi WT, Richard P, Płoski R, Truszkowska G, Baas AF, Foss-Nieradko B, Michalak E, Stępień-Wojno M, Zakrzewska-Koperska J, Śpiewak M, Zieliński T, Villard E, Te Riele ASJM, Katus HA, Frey N, Bilińska ZT, Charron P, Asselbergs FW, Meder B. Int J Cardiol. 2021 Sep 15;339:75-82. doi: 10.1016/j.ijcard.2021.07.002. Epub 2021 Jul 7. PMID: 34245791

 

Single-molecule, full-length transcript isoform sequencing reveals disease-associated RNA isoforms in cardiomyocytes. 

Zhu C, Wu J, Sun H, Briganti F, Meder B, Wei W, Steinmetz LM. Nat Commun. 2021 Jul 9;12(1):4203. doi: 10.1038/s41467-021-24484-z.PMID: 34244519 

 

Comparative Transcriptomics of Immune Checkpoint Inhibitor Myocarditis Identifies Guanylate Binding Protein 5 and 6 Dysregulation. 

Finke D, Heckmann MB, Salatzki J, Riffel J, Herpel E, Heinzerling LM, Meder B, Völkers M, Müller OJ, Frey N, Katus HA, Leuschner F, Kaya Z, Lehmann LH. Cancers (Basel). 2021 May 20;13(10):2498. doi: 10.3390/cancers13102498.PMID: 34065419

 

Prevalence and clinical outcomes of dystrophin-associated dilated cardiomyopathy without severe skeletal myopathy. 

Restrepo-Cordoba MA, Wahbi K, Florian AR, Jiménez-Jáimez J, Politano L, Arad M, Climent-Paya V, Garcia-Alvarez A, Hansen RB, Larrañaga-Moreira JM, Kubanek M, Lopes LR, Ros A, Jurcut R, Rasmussen TB, Ruiz-Guerrero L, Pribe-Wolferts R, Palomino-Doza J, Bilinska Z, Rodríguez-Palomares JF, Van Loon RLE, Basurte Elorz MT, Quarta G, Robledo Iñarritu M, Verdonschot JAJ, Stojkovic T, Shomanova Z, Bermudez-Jimenez F, Palladino A, Freimark D, García-Álvarez MI, Jorda P, Dominguez F, Ochoa JP, Girolami F, Brugada R, Meder B, Barriales-Villa R, Mogensen J, Laforêt P, Yilmaz A, Elliott P, Garcia-Pavia P; European Genetic Cardiomyopathies Initiative Investigators (see online supplementary Appendix S1). Eur J Heart Fail. 2021 Aug;23(8):1276-1286. doi: 10.1002/ejhf.2250. Epub 2021 Jun 9. PMID: 34050592 

 

Broad-Spectrum HDAC Inhibitors Promote Autophagy through FOXO Transcription Factors in Neuroblastoma. 

Körholz K, Ridinger J, Krunic D, Najafi S, Gerloff XF, Frese K, Meder B, Peterziel H, Vega-Rubin-de-Celis S, Witt O, Oehme I. Cells. 2021 Apr 24;10(5):1001. doi: 10.3390/cells10051001.PMID: 33923163

 

Prognostic impact of acute pulmonary triggers in patients with takotsubo syndrome: new insights from the International Takotsubo Registry. 

Kato K, Cammann VL, Napp LC, Szawan KA, Micek J, Dreiding S, Levinson RA, Petkova V, Würdinger M, Patrascu A, Sumalinog R, Gili S, Clarenbach CF, Kohler M, Wischnewsky M, Citro R, Vecchione C, Bossone E, Neuhaus M, Franke J, Meder B, Jaguszewski M, Noutsias M, Knorr M, Heiner S, D'Ascenzo F, Dichtl W, Burgdorf C, Kherad B, Tschöpe C, Sarcon A, Shinbane J, Rajan L, Michels G, Pfister R, Cuneo A, Jacobshagen C, Karakas M, Koenig W, Pott A, Meyer P, Roffi M, Banning A, Wolfrum M, Cuculi F, Kobza R, Fischer TA, Vasankari T, Airaksinen KEJ, Budnik M, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Chan C, Bridgman P, Beug D, Delmas C, Lairez O, Gilyarova E, Shilova A, Gilyarov M, El-Battrawy I, Akin I, Kozel M, Tousek P, Winchester DE, Galuszka J, Ukena C, Poglajen G, Carrilho-Ferreira P, Hauck C, Paolini C, Bilato C, Sano M, Ishibashi I, Takahara M, Himi T, Kobayashi Y, Prasad A, Rihal CS, Liu K, Schulze PC, Bianco M, Jörg L, Rickli H, Pestana G, Nguyen TH, Böhm M, Maier LS, Pinto FJ, Widimský P, Felix SB, Opolski G, Braun-Dullaeus RC, Rottbauer W, Hasenfuß G, Pieske BM, Schunkert H, Borggrefe M, Thiele H, Bauersachs J, Katus HA, Horowitz JD, Di Mario C, Münzel T, Crea F, Bax JJ, Lüscher TF, Ruschitzka F, Ghadri JR, Templin C. ESC Heart Fail. 2021 Jun;8(3):1924-1932. doi: 10.1002/ehf2.13165. Epub 2021 Mar 13. PMID: 33713566

 

Genome-wide association analysis in dilated cardiomyopathy reveals two new players in systolic heart failure on chromosomes 3p25.1 and 22q11.23. 

Garnier S, Harakalova M, Weiss S, Mokry M, Regitz-Zagrosek V, Hengstenberg C, Cappola TP, Isnard R, Arbustini E, Cook SA, van Setten J, Calis JJA, Hakonarson H, Morley MP, Stark K, Prasad SK, Li J, O'Regan DP, Grasso M, Müller-Nurasyid M, Meitinger T, Empana JP, Strauch K, Waldenberger M, Marguiles KB, Seidman CE, Kararigas G, Meder B, Haas J, Boutouyrie P, Lacolley P, Jouven X, Erdmann J, Blankenberg S, Wichter T, Ruppert V, Tavazzi L, Dubourg O, Roizes G, Dorent R, de Groote P, Fauchier L, Trochu JN, Aupetit JF, Bilinska ZT, Germain M, Völker U, Hemerich D, Raji I, Bacq-Daian D, Proust C, Remior P, Gomez-Bueno M, Lehnert K, Maas R, Olaso R, Saripella GV, Felix SB, McGinn S, Duboscq-Bidot L, van Mil A, Besse C, Fontaine V, Blanché H, Ader F, Keating B, Curjol A, Boland A, Komajda M, Cambien F, Deleuze JF, Dörr M, Asselbergs FW, Villard E, Trégouët DA, Charron P. Eur Heart J. 2021 May 21;42(20):2000-2011. doi: 10.1093/eurheartj/ehab030. PMID: 33677556

 

Energy Metabolites as Biomarkers in Ischemic and Dilated Cardiomyopathy. 

Haas J, Frese KS, Sedaghat-Hamedani F, Kayvanpour E, Tappu R, Nietsch R, Tugrul OF, Wisdom M, Dietrich C, Amr A, Weis T, Niederdränk T, Murphy MP, Krieg T, Dörr M, Völker U, Fielitz J, Frey N, Felix SB, Keller A, Katus HA, Meder B. Int J Mol Sci. 2021 Feb 18;22(4):1999. doi: 10.3390/ijms22041999.PMID: 33670449

 

Diagnostic value of circulating microRNAs compared to high-sensitivity troponin T for the detection of non-ST-segment elevation myocardial infarction. 

Biener M, Giannitsis E, Thum T, Bär C, Costa A, Andrzejewski T, Stoyanov KM, Vafaie M, Meder B, Katus HA, de Gonzalo-Calvo D, Mueller-Hennessen M. Eur Heart J Acute Cardiovasc Care. 2021 Aug 24;10(6):653-660. doi: 10.1093/ehjacc/zuaa034. PMID: 33580779 Clinical Trial. 

 

Back to the vinyl age: a narrative report of a total computer blackout at a large university medical centre. 

Lehmann LH, Meder B. Eur Heart J Digit Health. 2021 Feb 4;2(1):167-170. doi: 10.1093/ehjdh/ztab006. eCollection 2021 Mar. PMID: 36711185 Review.

 

Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect. 

Tadros R, Francis C, Xu X, Vermeer AMC, Harper AR, Huurman R, Kelu Bisabu K, Walsh R, Hoorntje ET, Te Rijdt WP, Buchan RJ, van Velzen HG, van Slegtenhorst MA, Vermeulen JM, Offerhaus JA, Bai W, de Marvao A, Lahrouchi N, Beekman L, Karper JC, Veldink JH, Kayvanpour E, Pantazis A, Baksi AJ, Whiffin N, Mazzarotto F, Sloane G, Suzuki H, Schneider-Luftman D, Elliott P, Richard P, Ader F, Villard E, Lichtner P, Meitinger T, Tanck MWT, van Tintelen JP, Thain A, McCarty D, Hegele RA, Roberts JD, Amyot J, Dubé MP, Cadrin-Tourigny J, Giraldeau G, L'Allier PL, Garceau P, Tardif JC, Boekholdt SM, Lumbers RT, Asselbergs FW, Barton PJR, Cook SA, Prasad SK, O'Regan DP, van der Velden J, Verweij KJH, Talajic M, Lettre G, Pinto YM, Meder B, Charron P, de Boer RA, Christiaans I, Michels M, Wilde AAM, Watkins H, Matthews PM, Ware JS, Bezzina CR. Nat Genet. 2021 Feb;53(2):128-134. doi: 10.1038/s41588-020-00762-2. Epub 2021 Jan 25. PMID: 33495596

 

Diagnosis and treatment of cardiac amyloidosis: position statement of the German Cardiac Society (DGK). 

Yilmaz A, Bauersachs J, Bengel F, Büchel R, Kindermann I, Klingel K, Knebel F, Meder B, Morbach C, Nagel E, Schulze-Bahr E, Aus dem Siepen F, Frey N. Clin Res Cardiol. 2021 Apr;110(4):479-506. doi: 10.1007/s00392-020-01799-3. Epub 2021 Jan 18.PMID: 33459839 Review.

 

Mavacamten Favorably Impacts Cardiac Structure in Obstructive Hypertrophic Cardiomyopathy: EXPLORER-HCM Cardiac Magnetic Resonance Substudy Analysis. 

Saberi S, Cardim N, Yamani M, Schulz-Menger J, Li W, Florea V, Sehnert AJ, Kwong RY, Jerosch-Herold M, Masri A, Owens A, Lakdawala NK, Kramer CM, Sherrid M, Seidler T, Wang A, Sedaghat-Hamedani F, Meder B, Havakuk O, Jacoby D. Circulation. 2021 Feb 9;143(6):606-608. doi: 10.1161/CIRCULATIONAHA.120.052359. Epub 2020 Nov 15. PMID: 33190524 No abstract available.

2020

Common diseases alter the physiological age-related blood microRNA profile. 

Fehlmann T, Lehallier B, Schaum N, Hahn O, Kahraman M, Li Y, Grammes N, Geffers L, Backes C, Balling R, Kern F, Krüger R, Lammert F, Ludwig N, Meder B, Fromm B, Maetzler W, Berg D, Brockmann K, Deuschle C, von Thaler AK, Eschweiler GW, Milman S, Barziliai N, Reichert M, Wyss-Coray T, Meese E, Keller A. Nat Commun. 2020 Nov 24;11(1):5958. doi: 10.1038/s41467-020-19665-1.PMID: 33235214

 

Mavacamten Favorably Impacts Cardiac Structure in Obstructive Hypertrophic Cardiomyopathy: EXPLORER-HCM Cardiac Magnetic Resonance Substudy Analysis. 

Saberi S, Cardim N, Yamani M, Schulz-Menger J, Li W, Florea V, Sehnert AJ, Kwong RY, Jerosch-Herold M, Masri A, Owens A, Lakdawala NK, Kramer CM, Sherrid M, Seidler T, Wang A, Sedaghat-Hamedani F, Meder B, Havakuk O, Jacoby D. Circulation. 2021 Feb 9;143(6):606-608. doi: 10.1161/CIRCULATIONAHA.120.052359. Epub 2020 Nov 15. PMID: 33190524 No abstract available.

 

Rapid In Vivo Validation of HDAC Inhibitor-Based Treatments in Neuroblastoma Zebrafish Xenografts. 

Wrobel JK, Najafi S, Ayhan S, Gatzweiler C, Krunic D, Ridinger J, Milde T, Westermann F, Peterziel H, Meder B, Distel M, Witt O, Oehme I. Pharmaceuticals (Basel). 2020 Oct 27;13(11):345. doi: 10.3390/ph13110345. PMID: 33121173 

 

Dual Functional States of R406W-Desmin Assembly Complexes Cause Cardiomyopathy With Severe Intercalated Disc Derangement in Humans and in Knock-In Mice. 

Herrmann H, Cabet E, Chevalier NR, Moosmann J, Schultheis D, Haas J, Schowalter M, Berwanger C, Weyerer V, Agaimy A, Meder B, Müller OJ, Katus HA, Schlötzer-Schrehardt U, Vicart P, Ferreiro A, Dittrich S, Clemen CS, Lilienbaum A, Schröder R. Circulation. 2020 Dec;142(22):2155-2171. doi: 10.1161/CIRCULATIONAHA.120.050218. Epub 2020 Oct 7. PMID: 33023321 

 

Clinical and Genetic Investigations of 109 Index Patients With Dilated Cardiomyopathy and 445 of Their Relatives. 

Hey TM, Rasmussen TB, Madsen T, Aagaard MM, Harbo M, Mølgaard H, Nielsen SK, Haas J, Meder B, Møller JE, Eiskjær H, Mogensen J. Circ Heart Fail. 2020 Oct;13(10):e006701. doi: 10.1161/CIRCHEARTFAILURE.119.006701. Epub 2020 Oct 6. PMID: 33019804

 

iPSC Modeling of RBM20-Deficient DCM Identifies Upregulation of RBM20 as a Therapeutic Strategy. 

Briganti F, Sun H, Wei W, Wu J, Zhu C, Liss M, Karakikes I, Rego S, Cipriano A, Snyder M, Meder B, Xu Z, Millat G, Gotthardt M, Mercola M, Steinmetz LM. Cell Rep. 2020 Sep 8;32(10):108117. doi: 10.1016/j.celrep.2020.108117.PMID: 32905764

 

Generation of pluripotent stem cell lines and CRISPR/Cas9 modified isogenic controls from a patient with dilated cardiomyopathy harboring a RBM20 p.R634W mutation. 

Rebs S, Sedaghat-Hamedani F, Kayvanpour E, Meder B, Streckfuss-Bömeke K. Stem Cell Res. 2020 Jul 2;47:101901. doi: 10.1016/j.scr.2020.101901. Online ahead of print. PMID: 32674065 

 

Deep Characterization of Circular RNAs from Human Cardiovascular Cell Models and Cardiac Tissue. 

Jakobi T, Siede D, Eschenbach J, Heumüller AW, Busch M, Nietsch R, Meder B, Most P, Dimmeler S, Backs J, Katus HA, Dieterich C. Cells. 2020 Jul 4;9(7):1616. doi: 10.3390/cells9071616. PMID: 32635460

 

Machine learning-based risk prediction of intrahospital clinical outcomes in patients undergoing TAVI. 

Gomes B, Pilz M, Reich C, Leuschner F, Konstandin M, Katus HA, Meder B. Clin Res Cardiol. 2021 Mar;110(3):343-356. doi: 10.1007/s00392-020-01691-0. Epub 2020 Jun 24. PMID: 32583062

 

The Patient as Genomic Data Manager - Evaluation of the PROMISE App. 

Griebel L, Hinderer M, Amr A, Meder B, Schweig M, Deuber D, Egger C, Kawohl C, Krämer A, Flade I, Schröder D, Prokosch HU. Stud Health Technol Inform. 2020 Jun 16;270:1061-1065. doi: 10.3233/SHTI200324.PMID: 32570544

 

Epigenetic Regulation of Alternative mRNA Splicing in Dilated Cardiomyopathy. 

Gi WT, Haas J, Sedaghat-Hamedani F, Kayvanpour E, Tappu R, Lehmann DH, Shirvani Samani O, Wisdom M, Keller A, Katus HA, Meder B. J Clin Med. 2020 May 16;9(5):1499. doi: 10.3390/jcm9051499. PMID: 32429430

 

Familial Recurrent Myocarditis Triggered by Exercise in Patients With a Truncating Variant of the Desmoplakin Gene. 

Poller W, Haas J, Klingel K, Kühnisch J, Gast M, Kaya Z, Escher F, Kayvanpour E, Degener F, Opgen-Rhein B, Berger F, Mochmann HC, Skurk C, Heidecker B, Schultheiss HP, Monserrat L, Meder B, Landmesser U, Klaassen S. J Am Heart Assoc. 2020 May 18;9(10):e015289. doi: 10.1161/JAHA.119.015289. Epub 2020 May 15. PMID: 32410525

 

Age-Related Variations in Takotsubo Syndrome. 

Cammann VL, Szawan KA, Stähli BE, Kato K, Budnik M, Wischnewsky M, Dreiding S, Levinson RA, Di Vece D, Gili S, Citro R, Bossone E, Neuhaus M, Franke J, Meder B, Jaguszewski M, Noutsias M, Knorr M, Heiner S, D'Ascenzo F, Dichtl W, Burgdorf C, Kherad B, Tschöpe C, Sarcon A, Shinbane J, Rajan L, Michels G, Pfister R, Cuneo A, Jacobshagen C, Karakas M, Koenig W, Pott A, Meyer P, Roffi M, Banning A, Wolfrum M, Cuculi F, Kobza R, Fischer TA, Vasankari T, Airaksinen KEJ, Napp LC, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Chan C, Bridgman P, Beug D, Delmas C, Lairez O, Gilyarova E, Shilova A, Gilyarov M, El-Battrawy I, Akin I, Poledniková K, Toušek P, Winchester DE, Galuszka J, Ukena C, Poglajen G, Carrilho-Ferreira P, Hauck C, Paolini C, Bilato C, Kobayashi Y, Shoji T, Ishibashi I, Takahara M, Himi T, Din J, Al-Shammari A, Prasad A, Rihal CS, Liu K, Schulze PC, Bianco M, Jörg L, Rickli H, Pestana G, Nguyen TH, Böhm M, Maier LS, Pinto FJ, Widimský P, Felix SB, Braun-Dullaeus RC, Rottbauer W, Hasenfuß G, Pieske BM, Schunkert H, Borggrefe M, Thiele H, Bauersachs J, Katus HA, Horowitz JD, Di Mario C, Münzel T, Crea F, Bax JJ, Lüscher TF, Ruschitzka F, Ghadri JR, Opolski G, Templin C. J Am Coll Cardiol. 2020 Apr 28;75(16):1869-1877. doi: 10.1016/j.jacc.2020.02.057. PMID: 32327096

 

microRNA neural networks improve diagnosis of acute coronary syndrome (ACS). 

Kayvanpour E, Gi WT, Sedaghat-Hamedani F, Lehmann DH, Frese KS, Haas J, Tappu R, Samani OS, Nietsch R, Kahraman M, Fehlmann T, Müller-Hennessen M, Weis T, Giannitsis E, Niederdränk T, Keller A, Katus HA, Meder B. J Mol Cell Cardiol. 2021 Feb;151:155-162. doi: 10.1016/j.yjmcc.2020.04.014. Epub 2020 Apr 17.PMID: 32305360

 

Predicting sustained ventricular arrhythmias in dilated cardiomyopathy: a meta-analysis and systematic review. 

Sammani A, Kayvanpour E, Bosman LP, Sedaghat-Hamedani F, Proctor T, Gi WT, Broezel A, Jensen K, Katus HA, Te Riele ASJM, Meder B, Asselbergs FW. ESC Heart Fail. 2020 Aug;7(4):1430-1441. doi: 10.1002/ehf2.12689. Epub 2020 Apr 14. PMID: 32285648

 

Postcardiac injury syndrome after cardiac implantable electronic device implantation. 

Filbey K, Sedaghat-Hamedani F, Kayvanpour E, Xynogalos P, Scherer D, Meder B, Katus HA, Zitron E. Herz. 2020 Nov;45(7):696-702. doi: 10.1007/s00059-020-04910-6. Epub 2020 Mar 13. PMID: 32170340

 

Heart-Specific Immune Responses in an Animal Model of Autoimmune-Related Myocarditis Mitigated by an Immunoproteasome Inhibitor and Genetic Ablation. 

Bockstahler M, Fischer A, Goetzke CC, Neumaier HL, Sauter M, Kespohl M, Müller AM, Meckes C, Salbach C, Schenk M, Heuser A, Landmesser U, Weiner J, Meder B, Lehmann L, Kratzer A, Klingel K, Katus HA, Kaya Z, Beling A. Circulation. 2020 Jun 9;141(23):1885-1902. doi: 10.1161/CIRCULATIONAHA.119.043171. Epub 2020 Mar 12. PMID: 32160764

 

Pulmonary vein isolation treats symptomatic AF in a patient with Lamin A/C mutation: case report and review of the literature.

Rahm AK, Lugenbiel P, Ochs M, Meder B, Thomas D, Katus HA, Scholz E.

Clin Res Cardiol. 2020 Aug;109(8):1070-1075. doi: 10.1007/s00392-020-01616-x. Epub 2020 Mar 6. PMID: 32144494 Review.

 

Evaluating the Use of Circulating MicroRNA Profiles for Lung Cancer Detection in Symptomatic Patients. 

Fehlmann T, Kahraman M, Ludwig N, Backes C, Galata V, Keller V, Geffers L, Mercaldo N, Hornung D, Weis T, Kayvanpour E, Abu-Halima M, Deuschle C, Schulte C, Suenkel U, von Thaler AK, Maetzler W, Herr C, Fähndrich S, Vogelmeier C, Guimaraes P, Hecksteden A, Meyer T, Metzger F, Diener C, Deutscher S, Abdul-Khaliq H, Stehle I, Haeusler S, Meiser A, Groesdonk HV, Volk T, Lenhof HP, Katus H, Balling R, Meder B, Kruger R, Huwer H, Bals R, Meese E, Keller A. JAMA Oncol. 2020 May 1;6(5):714-723. doi: 10.1001/jamaoncol.2020.0001.PMID: 32134442 

 

Cardiac Myxoma in a Patient With Hypertrophic Cardiomyopathy. 

Gi WT, Sedaghat-Hamedani F, Shirvani Samani O, Kayvanpour E, Herpel E, Arif R, Riffel J, Mereles D, Katus HA, Meder B. JACC Case Rep. 2020 Feb 12;2(3):378-383. doi: 10.1016/j.jaccas.2019.11.072. eCollection 2020 Mar.PMID: 34317246

 

Two Hearts at Risk: Emergency Alcohol Septal Ablation in a Pregnant Woman With Decompensated HOCM. 

Gi WT, Amr A, Sedaghat-Hamedani F, Kayvanpour E, Mohr I, Meder M, Shirvani Samani O, Fluhr H, Katus HA, Meder B. JACC Case Rep. 2020 Jan 15;2(1):139-144. doi: 10.1016/j.jaccas.2019.11.053. eCollection 2020 Jan. PMID: 

 

[Diagnostics and Treatment of Cardiac Sarcoidosis - Consensus Paper of the German Respiratory Society (DGP) and the German Cardiac Society (DGK)]. 

Skowasch D, Gaertner F, Marx N, Meder B, Müller-Quernheim J, Pfeifer M, Schrickel JW, Yilmaz A, Grohé C. Pneumologie. 2020 Jan;74(1):24-34. doi: 10.1055/a-1031-4588. Epub 2019 Dec 20. PMID: 31863422 German.

 

The chameleon of cardiology: cardiac sarcoidosis before and after heart transplantation. 

Sedaghat-Hamedani F, Kayvanpour E, Hamed S, Frankenstein L, Riffel J, Gi WT, Amr A, Shirvani Samani O, Haas J, Miersch T, Herpel E, Kreusser MM, Ehlermann P, Katus HA, Meder B. ESC Heart Fail. 2020 Apr;7(2):692-696. doi: 10.1002/ehf2.12581. Epub 2019 Dec 5. PMID: 31802644

 

The C-terminal HCN4 variant P883R alters channel properties and acts as genetic modifier of atrial fibrillation and structural heart disease. 

Weigl I, Geschwill P, Reiss M, Bruehl C, Draguhn A, Koenen M, Sedaghat-Hamedani F, Meder B, Thomas D, Katus HA, Schweizer PA. Biochem Biophys Res Commun. 2019 Oct 29;519(1):141-147. doi: 10.1016/j.bbrc.2019.08.150. Epub 2019 Aug 31. PMID: 31481236

 

Prevalence and relevance of impaired left ventricular function in chronic moderate regurgitation of native aortic valves.

Gomes B, Hees K, Hund H, Mereles D, Meder B, Katus HA, Bekeredjian R. Acta Cardiol. 2020 Nov;75(7):613-620. doi: 10.1080/00015385.2019.1639964. Epub 2019 Jul 16. PMID: 31311434

> 2020

Clinical and genetic insights into non-compaction: a meta-analysis and systematic review on 7598 individuals. 

Kayvanpour E, Sedaghat-Hamedani F, Gi WT, Tugrul OF, Amr A, Haas J, Zhu F, Ehlermann P, Uhlmann L, Katus HA, Meder B. Clin Res Cardiol. 2019 Nov;108(11):1297-1308. doi: 10.1007/s00392-019-01465-3. Epub 2019 Apr 12. PMID: 30980206

 

ANK2 functionally interacts with KCNH2 aggravating long QT syndrome in a double mutation carrier. 

Gessner G, Runge S, Koenen M, Heinemann SH, Koenen M, Haas J, Meder B, Thomas D, Katus HA, Schweizer PA. Biochem Biophys Res Commun. 2019 May 14;512(4):845-851. doi: 10.1016/j.bbrc.2019.03.162. Epub 2019 Mar 28. PMID: 30929919

 

[Digital Cardiology]. 

Meder B, Radke P. Dtsch Med Wochenschr. 2019 Apr;144(7):447-451. doi: 10.1055/a-0740-8631. Epub 2019 Mar 29. PMID: 30925598 German.

 

Long noncoding RNA NEAT1 modulates immune cell functions and is suppressed in early onset myocardial infarction patients. 

Gast M, Rauch BH, Haghikia A, Nakagawa S, Haas J, Stroux A, Schmidt D, Schumann P, Weiss S, Jensen L, Kratzer A, Kraenkel N, Müller C, Börnigen D, Hirose T, Blankenberg S, Escher F, Kühl AA, Kuss AW, Meder B, Landmesser U, Zeller T, Poller W. Cardiovasc Res. 2019 Nov 1;115(13):1886-1906. doi: 10.1093/cvr/cvz085. PMID: 30924864

 

Regional Variation in RBM20 Causes a Highly Penetrant Arrhythmogenic Cardiomyopathy. 

Parikh VN, Caleshu C, Reuter C, Lazzeroni LC, Ingles J, Garcia J, McCaleb K, Adesiyun T, Sedaghat-Hamedani F, Kumar S, Graw S, Gigli M, Stolfo D, Dal Ferro M, Ing AY, Nussbaum R, Funke B, Wheeler MT, Hershberger RE, Cook S, Steinmetz LM, Lakdawala NK, Taylor MRG, Mestroni L, Merlo M, Sinagra G, Semsarian C, Meder B, Judge DP, Ashley E. Circ Heart Fail. 2019 Mar;12(3):e005371. doi: 10.1161/CIRCHEARTFAILURE.118.005371. PMID: 30871351

 

Pathophysiological background and prognostic implication of systolic aortic root motion in non-ischemic dilated cardiomyopathy. 

Aurich M, Niemers M, Fuchs P, Greiner S, Müller-Hennessen M, Uhlmann L, Giannitsis E, Ehlermann P, Meder B, Katus HA, Mereles D. Sci Rep. 2019 Mar 7;9(1):3866. doi: 10.1038/s41598-019-40386-z.PMID: 30846742 

 

Identification and regulation of the long non-coding RNA Heat2 in heart failure. 

Boeckel JN, Perret MF, Glaser SF, Seeger T, Heumüller AW, Chen W, John D, Kokot KE, Katus HA, Haas J, Lackner MK, Kayvanpour E, Grabe N, Dieterich C, von Haehling S, Ebner N, Hünecke S, Leuschner F, Fichtlscherer S, Meder B, Zeiher AM, Dimmeler S, Keller T. J Mol Cell Cardiol. 2019 Jan;126:13-22. doi: 10.1016/j.yjmcc.2018.11.004. Epub 2018 Nov 13. PMID: 30445017

 

Periprocedural antibiotic treatment in transvascular aortic valve replacement. 

Gomes B, Geis NA, Leuschner F, Meder B, Konstandin M, Katus HA, Bekeredjian R. J Interv Cardiol. 2018 Dec;31(6):885-890. doi: 10.1111/joic.12567. Epub 2018 Nov 5. PMID: 30397939

 

Silencing the CSF-1 Axis Using Nanoparticle Encapsulated siRNA Mitigates Viral and Autoimmune Myocarditis. 

Meyer IS, Goetzke CC, Kespohl M, Sauter M, Heuser A, Eckstein V, Vornlocher HP, Anderson DG, Haas J, Meder B, Katus HA, Klingel K, Beling A, Leuschner F. Front Immunol. 2018 Oct 8;9:2303. doi: 10.3389/fimmu.2018.02303. eCollection 2018. PMID: 30349538

 

Immune system-mediated atherosclerosis caused by deficiency of long non-coding RNA MALAT1 in ApoE-/-mice. 

Gast M, Rauch BH, Nakagawa S, Haghikia A, Jasina A, Haas J, Nath N, Jensen L, Stroux A, Böhm A, Friebel J, Rauch U, Skurk C, Blankenberg S, Zeller T, Prasanth KV, Meder B, Kuss A, Landmesser U, Poller W. Cardiovasc Res. 2019 Feb 1;115(2):302-314. doi: 10.1093/cvr/cvy202. PMID: 30101304

 

Complex roads from genotype to phenotype in dilated cardiomyopathy: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology. 

Bondue A, Arbustini E, Bianco A, Ciccarelli M, Dawson D, De Rosa M, Hamdani N, Hilfiker-Kleiner D, Meder B, Leite-Moreira AF, Thum T, Tocchetti CG, Varricchi G, Van der Velden J, Walsh R, Heymans S. Cardiovasc Res. 2018 Aug 1;114(10):1287-1303. doi: 10.1093/cvr/cvy122. PMID: 29800419 Review.

 

Genetic Reduction in Left Ventricular Protein Kinase C-α and Adverse Ventricular Remodeling in Human Subjects. 

Hu R, Morley MP, Brandimarto J, Tucker NR, Parsons VA, Zhao SD, Meder B, Katus HA, Rühle F, Stoll M, Villard E, Cambien F, Lin H, Smith NL, Felix JF, Vasan RS, van der Harst P, Newton-Cheh C, Li J, Kim CE, Hakonarson H, Hannenhalli S, Ashley EA, Moravec CS, Tang WHW, Maillet M, Molkentin JD, Ellinor PT, Margulies KB, Cappola TP. Circ Genom Precis Med. 2018 Mar;11(3):e001901. doi: 10.1161/CIRCGEN.117.001901. PMID: 29540468

 

A kinome-wide RNAi screen identifies ALK as a target to sensitize neuroblastoma cells for HDAC8-inhibitor treatment. 

Shen J, Najafi S, Stäble S, Fabian J, Koeneke E, Kolbinger FR, Wrobel JK, Meder B, Distel M, Heimburg T, Sippl W, Jung M, Peterziel H, Kranz D, Boutros M, Westermann F, Witt O, Oehme I. Cell Death Differ. 2018 Dec;25(12):2053-2070. doi: 10.1038/s41418-018-0080-0. Epub 2018 Mar 7. PMID: 29515255

 

Left Ventricular Biopsy in the Diagnosis of Myocardial Diseases. 

Frey N, Meder B, Katus HA. Circulation. 2018 Mar 6;137(10):993-995. doi: 10.1161/CIRCULATIONAHA.117.030834. PMID: 29506992 No abstract available.

 

Unidimensional Longitudinal Strain: A Simple Approach for the Assessment of Longitudinal Myocardial Deformation by Echocardiography. 

Aurich M, Fuchs P, Müller-Hennessen M, Uhlmann L, Niemers M, Greiner S, Täger T, Hirschberg K, Ehlermann P, Meder B, Frankenstein L, Giannitsis E, Katus HA, Mereles D. J Am Soc Echocardiogr. 2018 Jun;31(6):733-742. doi: 10.1016/j.echo.2017.12.010. Epub 2018 Feb 21.PMID: 29402506

 

A high-resolution map of the human small non-coding transcriptome. 

Fehlmann T, Backes C, Alles J, Fischer U, Hart M, Kern F, Langseth H, Rounge T, Umu SU, Kahraman M, Laufer T, Haas J, Staehler C, Ludwig N, Hübenthal M, Meder B, Franke A, Lenhof HP, Meese E, Keller A. Bioinformatics. 2018 May 15;34(10):1621-1628. doi: 10.1093/bioinformatics/btx814.PMID: 29281000

 

Precision medicine for cardiovascular disease : Learning lessons from cardiomyopathies. 

Sedaghat-Hamedani F, Katus HA, Meder B. Herz. 2018 Mar;43(2):123-130. doi: 10.1007/s00059-017-4667-x. PMID: 29260236 Review. English.

 

A proteolytic fragment of histone deacetylase 4 protects the heart from failure by regulating the hexosamine biosynthetic pathway. 

Lehmann LH, Jebessa ZH, Kreusser MM, Horsch A, He T, Kronlage M, Dewenter M, Sramek V, Oehl U, Krebs-Haupenthal J, von der Lieth AH, Schmidt A, Sun Q, Ritterhoff J, Finke D, Völkers M, Jungmann A, Sauer SW, Thiel C, Nickel A, Kohlhaas M, Schäfer M, Sticht C, Maack C, Gretz N, Wagner M, El-Armouche A, Maier LS, Londoño JEC, Meder B, Freichel M, Gröne HJ, Most P, Müller OJ, Herzig S, Furlong EEM, Katus HA, Backs J. Nat Med. 2018 Jan;24(1):62-72. doi: 10.1038/nm.4452. Epub 2017 Dec 11. PMID: 29227474

 

Genomic structural variations lead to dysregulation of important coding and non-coding RNA species in dilated cardiomyopathy. 

Haas J, Mester S, Lai A, Frese KS, Sedaghat-Hamedani F, Kayvanpour E, Rausch T, Nietsch R, Boeckel JN, Carstensen A, Völkers M, Dietrich C, Pils D, Amr A, Holzer DB, Martins Bordalo D, Oehler D, Weis T, Mereles D, Buss S, Riechert E, Wirsz E, Wuerstle M, Korbel JO, Keller A, Katus HA, Posch AE, Meder B. EMBO Mol Med. 2018 Jan;10(1):107-120. doi: 10.15252/emmm.201707838.PMID: 29138229

 

Clinical genetics and outcome of left ventricular non-compaction cardiomyopathy. 

Sedaghat-Hamedani F, Haas J, Zhu F, Geier C, Kayvanpour E, Liss M, Lai A, Frese K, Pribe-Wolferts R, Amr A, Li DT, Samani OS, Carstensen A, Bordalo DM, Müller M, Fischer C, Shao J, Wang J, Nie M, Yuan L, Haßfeld S, Schwartz C, Zhou M, Zhou Z, Shu Y, Wang M, Huang K, Zeng Q, Cheng L, Fehlmann T, Ehlermann P, Keller A, Dieterich C, Streckfuß-Bömeke K, Liao Y, Gotthardt M, Katus HA, Meder B. Eur Heart J. 2017 Dec 7;38(46):3449-3460. doi: 10.1093/eurheartj/ehx545. PMID: 29029073 

 

Severe DCM phenotype of patient harboring RBM20 mutation S635A can be modeled by patient-specific induced pluripotent stem cell-derived cardiomyocytes. 

Streckfuss-Bömeke K, Tiburcy M, Fomin A, Luo X, Li W, Fischer C, Özcelik C, Perrot A, Sossalla S, Haas J, Vidal RO, Rebs S, Khadjeh S, Meder B, Bonn S, Linke WA, Zimmermann WH, Hasenfuss G, Guan K. J Mol Cell Cardiol. 2017 Dec;113:9-21. doi: 10.1016/j.yjmcc.2017.09.008. Epub 2017 Sep 21. PMID: 28941705 

 

Web-based NGS data analysis using miRMaster: a large-scale meta-analysis of human miRNAs. 

Fehlmann T, Backes C, Kahraman M, Haas J, Ludwig N, Posch AE, Würstle ML, Hübenthal M, Franke A, Meder B, Meese E, Keller A. Nucleic Acids Res. 2017 Sep 6;45(15):8731-8744. doi: 10.1093/nar/gkx595. PMID: 28911107

 

Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy. 

Heinig M, Adriaens ME, Schafer S, van Deutekom HWM, Lodder EM, Ware JS, Schneider V, Felkin LE, Creemers EE, Meder B, Katus HA, Rühle F, Stoll M, Cambien F, Villard E, Charron P, Varro A, Bishopric NH, George AL Jr, Dos Remedios C, Moreno-Moral A, Pesce F, Bauerfeind A, Rüschendorf F, Rintisch C, Petretto E, Barton PJ, Cook SA, Pinto YM, Bezzina CR, Hubner N. Genome Biol. 2017 Sep 14;18(1):170. doi: 10.1186/s13059-017-1286-z. PMID: 28903782

 

Clinical outcomes associated with sarcomere mutations in hypertrophic cardiomyopathy: a meta-analysis on 7675 individuals. 

Sedaghat-Hamedani F, Kayvanpour E, Tugrul OF, Lai A, Amr A, Haas J, Proctor T, Ehlermann P, Jensen K, Katus HA, Meder B. Clin Res Cardiol. 2018 Jan;107(1):30-41. doi: 10.1007/s00392-017-1155-5. Epub 2017 Aug 24. PMID: 28840316 Review.

 

Epigenome-Wide Association Study Identifies Cardiac Gene Patterning and a Novel Class of Biomarkers for Heart Failure. 

Meder B, Haas J, Sedaghat-Hamedani F, Kayvanpour E, Frese K, Lai A, Nietsch R, Scheiner C, Mester S, Bordalo DM, Amr A, Dietrich C, Pils D, Siede D, Hund H, Bauer A, Holzer DB, Ruhparwar A, Mueller-Hennessen M, Weichenhan D, Plass C, Weis T, Backs J, Wuerstle M, Keller A, Katus HA, Posch AE. Circulation. 2017 Oct 17;136(16):1528-1544. doi: 10.1161/CIRCULATIONAHA.117.027355. Epub 2017 Aug 24. PMID: 28838933

 

Catecholamine-Dependent β-Adrenergic Signaling in a Pluripotent Stem Cell Model of Takotsubo Cardiomyopathy. 

Borchert T, Hübscher D, Guessoum CI, Lam TD, Ghadri JR, Schellinger IN, Tiburcy M, Liaw NY, Li Y, Haas J, Sossalla S, Huber MA, Cyganek L, Jacobshagen C, Dressel R, Raaz U, Nikolaev VO, Guan K, Thiele H, Meder B, Wollnik B, Zimmermann WH, Lüscher TF, Hasenfuss G, Templin C, Streckfuss-Bömeke K. J Am Coll Cardiol. 2017 Aug 22;70(8):975-991. doi: 10.1016/j.jacc.2017.06.061.PMID: 28818208 

 

TranslatiOnal Registry for CardiomyopatHies (TORCH) - rationale and first results. 

Seyler C, Meder B, Weis T, Schwaneberg T, Weitmann K, Hoffmann W, Katus HA, Dösch A. ESC Heart Fail. 2017 Aug;4(3):209-215. doi: 10.1002/ehf2.12145. Epub 2017 Mar 14. PMID: 28772045

 

Identification of circular RNAs with host gene-independent expression in human model systems for cardiac differentiation and disease. 

Siede D, Rapti K, Gorska AA, Katus HA, Altmüller J, Boeckel JN, Meder B, Maack C, Völkers M, Müller OJ, Backs J, Dieterich C. J Mol Cell Cardiol. 2017 Aug;109:48-56. doi: 10.1016/j.yjmcc.2017.06.015. Epub 2017 Jul 1. PMID: 28676412

 

Precision medicine approach to genetic cardiomyopathy. 

Filonenko K, Katus HA, Meder B. Herz. 2017 Aug;42(5):468-475. doi: 10.1007/s00059-017-4592-z.PMID: 28653114 Review.English. 

 

Identification and Functional Characterization of Hypoxia-Induced Endoplasmic Reticulum Stress Regulating lncRNA (HypERlnc) in Pericytes. 

Bischoff FC, Werner A, John D, Boeckel JN, Melissari MT, Grote P, Glaser SF, Demolli S, Uchida S, Michalik KM, Meder B, Katus HA, Haas J, Chen W, Pullamsetti SS, Seeger W, Zeiher AM, Dimmeler S, Zehendner CM. Circ Res. 2017 Aug 4;121(4):368-375. doi: 10.1161/CIRCRESAHA.116.310531. Epub 2017 Jun 13. PMID: 28611075 

 

Non-coding RNAs in cardiovascular diseases: diagnostic and therapeutic perspectives. 

Poller W, Dimmeler S, Heymans S, Zeller T, Haas J, Karakas M, Leistner DM, Jakob P, Nakagawa S, Blankenberg S, Engelhardt S, Thum T, Weber C, Meder B, Hajjar R, Landmesser U. Eur Heart J. 2018 Aug 1;39(29):2704-2716. doi: 10.1093/eurheartj/ehx165. PMID: 28430919 Review. 

 

The prognostic value of right ventricular long axis strain in non-ischaemic dilated cardiomyopathies using standard cardiac magnetic resonance imaging. 

Arenja N, Riffel JH, Halder M, Djiokou CN, Fritz T, Andre F, Aus dem Siepen F, Zelniker T, Meder B, Kayvanpour E, Korosoglou G, Katus HA, Buss SJ. Eur Radiol. 2017 Sep;27(9):3913-3923. doi: 10.1007/s00330-016-4729-0. Epub 2017 Feb 10. PMID: 28188427 

 

miRNAs in Ancient Tissue Specimens of the Tyrolean Iceman. 

Keller A, Kreis S, Leidinger P, Maixner F, Ludwig N, Backes C, Galata V, Guerriero G, Fehlmann T, Franke A, Meder B, Zink A, Meese E. Mol Biol Evol. 2017 Apr 1;34(4):793-801. doi: 10.1093/molbev/msw291. PMID: 28025275 

 

Nucleoside Diphosphate Kinase-C Suppresses cAMP Formation in Human Heart Failure. 

Abu-Taha IH, Heijman J, Hippe HJ, Wolf NM, El-Armouche A, Nikolaev VO, Schäfer M, Würtz CM, Neef S, Voigt N, Baczkó I, Varró A, Müller M, Meder B, Katus HA, Spiger K, Vettel C, Lehmann LH, Backs J, Skolnik EY, Lutz S, Dobrev D, Wieland T. Circulation. 2017 Feb 28;135(9):881-897. doi: 10.1161/CIRCULATIONAHA.116.022852. Epub 2016 Dec 7. PMID: 27927712 

 

microRNA assays for acute coronary syndromes. 

Shirvani Samani O, Meder B. Diagnosis (Berl). 2016 Dec 1;3(4):183-188. doi: 10.1515/dx-2016-0025. PMID: 29536899 Review. 

 

Improvements of Procedural Results With a New-Generation Self-Expanding Transfemoral Aortic Valve Prosthesis in Comparison to the Old-Generation Device. 

Gomes B, Geis NA, Chorianopoulos E, Meder B, Leuschner F, Katus HA, Bekeredjian R. J Interv Cardiol. 2017 Feb;30(1):72-78. doi: 10.1111/joic.12356. Epub 2016 Nov 24. PMID: 27882613 

 

Initial Single-Center Experience With the Fully Repositionable Transfemoral Lotus Aortic Valve System. 

Jarr KU, Leuschner F, Meder B, Katus HA, Bekeredjian R, Chorianopoulos E. J Invasive Cardiol. 2017 Jan;29(1):30-35. Epub 2016 Nov 15. PMID: 27845874 

 

Erratum to: miRNAs and sports: tracking training status and potentially confounding diagnoses. 

Hecksteden A, Leidinger P, Backes C, Rheinheimer S, Pfeiffer M, Ferrauti A, Kellmann M, Sedaghat-Hamedani F, Meder B, Meese E, Meyer T, Keller A. J Transl Med. 2016 Oct 13;14(1):293. doi: 10.1186/s12967-016-1054-y.PMID: 27737682 No abstract available. 

 

Genotype-phenotype associations in dilated cardiomyopathy: meta-analysis on more than 8000 individuals. 

Kayvanpour E, Sedaghat-Hamedani F, Amr A, Lai A, Haas J, Holzer DB, Frese KS, Keller A, Jensen K, Katus HA, Meder B. Clin Res Cardiol. 2017 Feb;106(2):127-139. doi: 10.1007/s00392-016-1033-6. Epub 2016 Aug 30. PMID: 27576561Review. 

 

Computational Cardiology - A New Discipline of Translational Research. 

Meder B, Katus HA, Keller A. Genomics Proteomics Bioinformatics. 2016 Aug;14(4):177-8. doi: 10.1016/j.gpb.2016.08.001. Epub 2016 Aug 3. PMID: 27497711 No abstract available. 

 

A mutation in the glutamate-rich region of RNA-binding motif protein 20 causes dilated cardiomyopathy through missplicing of titin and impaired Frank-Starling mechanism. 

Beqqali A, Bollen IA, Rasmussen TB, van den Hoogenhof MM, van Deutekom HW, Schafer S, Haas J, Meder B, Sørensen KE, van Oort RJ, Mogensen J, Hubner N, Creemers EE, van der Velden J, Pinto YM. Cardiovasc Res. 2016 Oct;112(1):452-63. doi: 10.1093/cvr/cvw192. Epub 2016 Aug 5. PMID: 27496873 

 

Personalized Computer Simulation of Diastolic Function in Heart Failure. 

Amr A, Kayvanpour E, Sedaghat-Hamedani F, Passerini T, Mihalef V, Lai A, Neumann D, Georgescu B, Buss S, Mereles D, Zitron E, Posch AE, Würstle M, Mansi T, Katus HA, Meder B. Genomics Proteomics Bioinformatics. 2016 Aug;14(4):244-52. doi: 10.1016/j.gpb.2016.04.006. Epub 2016 Jul 29. PMID: 27477449 

 

The Role of Quality Control in Targeted Next-generation Sequencing Library Preparation. 

Nietsch R, Haas J, Lai A, Oehler D, Mester S, Frese KS, Sedaghat-Hamedani F, Kayvanpour E, Keller A, Meder B. Genomics Proteomics Bioinformatics. 2016 Aug;14(4):200-6. doi: 10.1016/j.gpb.2016.04.007. Epub 2016 Jul 28. PMID: 27475404

 

miRNAs and sports: tracking training status and potentially confounding diagnoses. 

Hecksteden A, Leidinger P, Backes C, Rheinheimer S, Pfeiffer M, Ferrauti A, Kellmann M, Sedaghat-Hamedani F, Meder B, Meese E, Meyer T, Keller A. J Transl Med. 2016 Jul 26;14(1):219. doi: 10.1186/s12967-016-0974-x.PMID: 27456854 Clinical Trial. 

 

Left ventricular long axis strain: a new prognosticator in non-ischemic dilated cardiomyopathy? 

Riffel JH, Keller MG, Rost F, Arenja N, Andre F, Aus dem Siepen F, Fritz T, Ehlermann P, Taeger T, Frankenstein L, Meder B, Katus HA, Buss SJ. J Cardiovasc Magn Reson. 2016 Jun 7;18(1):36. doi: 10.1186/s12968-016-0255-0. PMID: 27268238 

 

A self-taught artificial agent for multi-physics computational model personalization. 

Neumann D, Mansi T, Itu L, Georgescu B, Kayvanpour E, Sedaghat-Hamedani F, Amr A, Haas J, Katus H, Meder B, Steidl S, Hornegger J, Comaniciu D. Med Image Anal. 2016 Dec;34:52-64. doi: 10.1016/j.media.2016.04.003. Epub 2016 Apr 21. PMID: 27133269 

 

Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression. 

Eden M, Meder B, Völkers M, Poomvanicha M, Domes K, Branchereau M, Marck P, Will R, Bernt A, Rangrez A, Busch M; German Mouse Clinic Consortium; Hrabě de Angelis M, Heymes C, Rottbauer W, Most P, Hofmann F, Frey N. Nat Commun. 2016 Apr 28;7:11317. doi: 10.1315/11317. PMID: 27122098

 

MiRTargetLink--miRNAs, Genes and Interaction Networks. 

Hamberg M, Backes C, Fehlmann T, Hart M, Meder B, Meese E, Keller A. Int J Mol Sci. 2016 Apr 14;17(4):564. doi: 10.3390/ijms17040564.PMID: 27089332 

 

Essential light chain S195 phosphorylation is required for cardiac adaptation under physical stress. 

Scheid LM, Mosqueira M, Hein S, Kossack M, Juergensen L, Mueller M, Meder B, Fink RH, Katus HA, Hassel D. Cardiovasc Res. 2016 Jul 1;111(1):44-55. doi: 10.1093/cvr/cvw066. Epub 2016 Mar 24. PMID: 27013636 

 

Distribution of miRNA expression across human tissues. 

Ludwig N, Leidinger P, Becker K, Backes C, Fehlmann T, Pallasch C, Rheinheimer S, Meder B, Stähler C, Meese E, Keller A. Nucleic Acids Res. 2016 May 5;44(8):3865-77. doi: 10.1093/nar/gkw116. Epub 2016 Feb 25. PMID: 26921406 

 

Deep characterization of blood cell miRNomes by NGS. 

Schwarz EC, Backes C, Knörck A, Ludwig N, Leidinger P, Hoxha C, Schwär G, Grossmann T, Müller SC, Hart M, Haas J, Galata V, Müller I, Fehlmann T, Eichler H, Franke A, Meder B, Meese E, Hoth M, Keller A. Cell Mol Life Sci. 2016 Aug;73(16):3169-81. doi: 10.1007/s00018-016-2154-9. Epub 2016 Feb 13. PMID: 26874686 

 

Long noncoding RNA MALAT1-derived mascRNA is involved in cardiovascular innate immunity. 

Gast M, Schroen B, Voigt A, Haas J, Kuehl U, Lassner D, Skurk C, Escher F, Wang X, Kratzer A, Michalik K, Papageorgiou A, Peters T, Loebel M, Wilk S, Althof N, Prasanth KV, Katus H, Meder B, Nakagawa S, Scheibenbogen C, Schultheiss HP, Landmesser U, Dimmeler S, Heymans S, Poller W. J Mol Cell Biol. 2016 Apr;8(2):178-81. doi: 10.1093/jmcb/mjw003. Epub 2016 Jan 27. PMID: 26823496 No abstract available. 

 

Validating Alzheimer's disease micro RNAs using next-generation sequencing. 

Keller A, Backes C, Haas J, Leidinger P, Maetzler W, Deuschle C, Berg D, Ruschil C, Galata V, Ruprecht K, Stähler C, Würstle M, Sickert D, Gogol M, Meder B, Meese E. Alzheimers Dement. 2016 May;12(5):565-76. doi: 10.1016/j.jalz.2015.12.012. Epub 2016 Jan 22. PMID: 26806387 

 

Bias in High-Throughput Analysis of miRNAs and Implications for Biomarker Studies. 

Backes C, Sedaghat-Hamedani F, Frese K, Hart M, Ludwig N, Meder B, Meese E, Keller A. Anal Chem. 2016 Feb 16;88(4):2088-95. doi: 10.1021/acs.analchem.5b03376. Epub 2016 Jan 27. PMID: 26760198 

 

Prioritizing and selecting likely novel miRNAs from NGS data. 

Backes C, Meder B, Hart M, Ludwig N, Leidinger P, Vogel B, Galata V, Roth P, Menegatti J, Grässer F, Ruprecht K, Kahraman M, Grossmann T, Haas J, Meese E, Keller A. Nucleic Acids Res. 2016 Apr 7;44(6):e53. doi: 10.1093/nar/gkv1335. Epub 2015 Dec 3. PMID: 26635395 

 

Transitive reasoning distorts induction in causal chains. 

von Sydow M, Hagmayer Y, Meder B. Mem Cognit. 2016 Apr;44(3):469-87. doi: 10.3758/s13421-015-0568-5. PMID: 26620811 

 

From Single Variants to Protein Cascades: MULTISCALE MODELING OF SINGLE NUCLEOTIDE VARIANT SETS IN GENETIC DISORDERS. 

Mueller SC, Sommer B, Backes C, Haas J, Meder B, Meese E, Keller A. J Biol Chem. 2016 Jan 22;291(4):1582-1590. doi: 10.1074/jbc.M115.695247. Epub 2015 Nov 24. PMID: 26601959

 

Double-Stranded Ligation Assay for the Rapid Multiplex Quantification of MicroRNAs. 

Hofmann S, Huang Y, Paulicka P, Kappel A, Katus HA, Keller A, Meder B, Stähler CF, Gumbrecht W. Anal Chem. 2015 Dec 15;87(24):12104-11. doi: 10.1021/acs.analchem.5b02850. Epub 2015 Dec 2. PMID: 26574152

 

Pathway-based variant enrichment analysis on the example of dilated cardiomyopathy. 

Backes C, Meder B, Lai A, Stoll M, Rühle F, Katus HA, Keller A. Hum Genet. 2016 Jan;135(1):31-40. doi: 10.1007/s00439-015-1609-7. Epub 2015 Nov 7. PMID: 26547721 

 

Next-generation sequencing identifies altered whole blood microRNAs in neuromyelitis optica spectrum disorder which may permit discrimination from multiple sclerosis. 

Keller A, Leidinger P, Meese E, Haas J, Backes C, Rasche L, Behrens JR, Pfuhl C, Wakonig K, Gieß RM, Jarius S, Meder B, Bellmann-Strobl J, Paul F, Pache FC, Ruprecht K. J Neuroinflammation. 2015 Oct 31;12:196. doi: 10.1186/s12974-015-0418-1.PMID: 26521232 

 

Biomarker changes after strenuous exercise can mimic pulmonary embolism and cardiac injury--a metaanalysis of 45 studies. 

Sedaghat-Hamedani F, Kayvanpour E, Frankenstein L, Mereles D, Amr A, Buss S, Keller A, Giannitsis E, Jensen K, Katus HA, Meder B. Clin Chem. 2015 Oct;61(10):1246-55. doi: 10.1373/clinchem.2015.240796. Epub 2015 Aug 3. PMID: 26240298 Review.

 

Determined to Fail--the Role of Genetic Mechanisms in Heart Failure. 

Kayvanpour E, Katus HA, Meder B. Curr Heart Fail Rep. 2015 Oct;12(5):333-8. doi: 10.1007/s11897-015-0264-6. PMID: 26233853 Review. 

 

Towards Personalized Cardiology: Multi-Scale Modeling of the Failing Heart. 

Kayvanpour E, Mansi T, Sedaghat-Hamedani F, Amr A, Neumann D, Georgescu B, Seegerer P, Kamen A, Haas J, Frese KS, Irawati M, Wirsz E, King V, Buss S, Mereles D, Zitron E, Keller A, Katus HA, Comaniciu D, Meder B. PLoS One. 2015 Jul 31;10(7):e0134869. doi: 10.1371/journal.pone.0134869. eCollection 2015. PMID: 26230546

 

So rare we need to hunt for them: reframing the ethical debate on incidental findings. 

Schuol S, Schickhardt C, Wiemann S, Bartram CR, Tanner K, Eils R, Meder B, Richter D, Glimm H, von Kalle C, Winkler EC. Genome Med. 2015 Jul 30;7(1):83. doi: 10.1186/s13073-015-0198-3. eCollection 2015. PMID: 26229554

 

Influence of next-generation sequencing and storage conditions on miRNA patterns generated from PAXgene blood. 

Backes C, Leidinger P, Altmann G, Wuerstle M, Meder B, Galata V, Mueller SC, Sickert D, Stähler C, Meese E, Keller A. Anal Chem. 2015 Sep 1;87(17):8910-6. doi: 10.1021/acs.analchem.5b02043. Epub 2015 Aug 10. PMID: 26207298 

 

BALL-SNP: combining genetic and structural information to identify candidate non-synonymous single nucleotide polymorphisms. 

Mueller SC, Backes C, Kalinina OV, Meder B, Stöckel D, Lenhof HP, Meese E, Keller A. Genome Med. 2015 Jul 1;7(1):65. doi: 10.1186/s13073-015-0190-y. eCollection 2015. PMID: 26191084

 

miFRame: analysis and visualization of miRNA sequencing data in neurological disorders. 

Backes C, Haas J, Leidinger P, Frese K, Großmann T, Ruprecht K, Meder B, Meese E, Keller A. J Transl Med. 2015 Jul 14;13:224. doi: 10.1186/s12967-015-0594-x. PMID: 26169944

 

RNA splicing regulated by RBFOX1 is essential for cardiac function in zebrafish. 

Frese KS, Meder B, Keller A, Just S, Haas J, Vogel B, Fischer S, Backes C, Matzas M, Köhler D, Benes V, Katus HA, Rottbauer W. J Cell Sci. 2015 Aug 15;128(16):3030-40. doi: 10.1242/jcs.166850. Epub 2015 Jun 26. PMID: 26116573

 

Involvement of BAG3 and HSPB7 loci in various etiologies of systolic heart failure: Results of a European collaboration assembling more than 2000 patients. 

Garnier S, Hengstenberg C, Lamblin N, Dubourg O, De Groote P, Fauchier L, Trochu JN, Arbustini E, Esslinger U, Barton PJ, Meder B, Katus H, Frese K, Komajda M, Cook SA, Isnard R, Tiret L, Villard E, Charron P. Int J Cardiol. 2015;189:105-7. doi: 10.1016/j.ijcard.2015.04.003. Epub 2015 Apr 1. PMID: 25889438 No abstract available.

 

The current role of next-generation DNA sequencing in routine care of patients with hereditary cardiovascular conditions: a viewpoint paper of the European Society of Cardiology working group on myocardial and pericardial diseases and members of the European Society of Human Genetics. 

Mogensen J, van Tintelen JP, Fokstuen S, Elliott P, van Langen IM, Meder B, Richard P, Syrris P, Caforio AL, Adler Y, Anastasakis A, Gimeno JR, Klingel K, Linhart A, Imazio M, Pinto Y, Newbery R, Schmidtke J, Charron P. Eur Heart J. 2015 Jun 7;36(22):1367-70. doi: 10.1093/eurheartj/ehv122. Epub 2015 Apr 5. PMID: 25845928 Review. No abstract available. 

 

MicroRNA in vitro diagnostics using immunoassay analyzers. 

Kappel A, Backes C, Huang Y, Zafari S, Leidinger P, Meder B, Schwarz H, Gumbrecht W, Meese E, Staehler CF, Keller A. Clin Chem. 2015 Apr;61(4):600-7. doi: 10.1373/clinchem.2014.232165. Epub 2015 Jan 23. PMID: 25617425 

 

New insights into the genetics of glioblastoma multiforme by familial exome sequencing. 

Backes C, Harz C, Fischer U, Schmitt J, Ludwig N, Petersen BS, Mueller SC, Kim YJ, Wolf NM, Katus HA, Meder B, Furtwängler R, Franke A, Bohle R, Henn W, Graf N, Keller A, Meese E. Oncotarget. 2015 Mar 20;6(8):5918-31. doi: 10.18632/oncotarget.2950. PMID: 25537509

 

miRNAs can be generally associated with human pathologies as exemplified for miR-144. 

Keller A, Leidinger P, Vogel B, Backes C, ElSharawy A, Galata V, Mueller SC, Marquart S, Schrauder MG, Strick R, Bauer A, Wischhusen J, Beier M, Kohlhaas J, Katus HA, Hoheisel J, Franke A, Meder B, Meese E. BMC Med. 2014 Dec 3;12:224. doi: 10.1186/s12916-014-0224-0. PMID: 25465851 

 

Effects of β-blocker therapy on electrocardiographic and echocardiographic characteristics of left ventricular noncompaction. 

Li J, Franke J, Pribe-Wolferts R, Meder B, Ehlermann P, Mereles D, Andre F, Abdelrazek MA, Merten C, Schweizer PA, Becker R, Katus HA, Thomas D. Clin Res Cardiol. 2015 Mar;104(3):241-9. doi: 10.1007/s00392-014-0778-z. Epub 2014 Oct 21. PMID: 25331160 

 

Assessment of myocardial deformation with cardiac magnetic resonance strain imaging improves risk stratification in patients with dilated cardiomyopathy. 

Buss SJ, Breuninger K, Lehrke S, Voss A, Galuschky C, Lossnitzer D, Andre F, Ehlermann P, Franke J, Taeger T, Frankenstein L, Steen H, Meder B, Giannitsis E, Katus HA, Korosoglou G. Eur Heart J Cardiovasc Imaging. 2015 Mar;16(3):307-15. doi: 10.1093/ehjci/jeu181. Epub 2014 Sep 21.PMID: 25246506 

 

Atlas of the clinical genetics of human dilated cardiomyopathy. 

Haas J, Frese KS, Peil B, Kloos W, Keller A, Nietsch R, Feng Z, Müller S, Kayvanpour E, Vogel B, Sedaghat-Hamedani F, Lim WK, Zhao X, Fradkin D, Köhler D, Fischer S, Franke J, Marquart S, Barb I, Li DT, Amr A, Ehlermann P, Mereles D, Weis T, Hassel S, Kremer A, King V, Wirsz E, Isnard R, Komajda M, Serio A, Grasso M, Syrris P, Wicks E, Plagnol V, Lopes L, Gadgaard T, Eiskjær H, Jørgensen M, Garcia-Giustiniani D, Ortiz-Genga M, Crespo-Leiro MG, Deprez RH, Christiaans I, van Rijsingen IA, Wilde AA, Waldenstrom A, Bolognesi M, Bellazzi R, Mörner S, Bermejo JL, Monserrat L, Villard E, Mogensen J, Pinto YM, Charron P, Elliott P, Arbustini E, Katus HA, Meder B. Eur Heart J. 2015 May 7;36(18):1123-35a. doi: 10.1093/eurheartj/ehu301. Epub 2014 Aug 27. PMID: 25163546 

 

Silencing of CCR2 in myocarditis. 

Leuschner F, Courties G, Dutta P, Mortensen LJ, Gorbatov R, Sena B, Novobrantseva TI, Borodovsky A, Fitzgerald K, Koteliansky V, Iwamoto Y, Bohlender M, Meyer S, Lasitschka F, Meder B, Katus HA, Lin C, Libby P, Swirski FK, Anderson DG, Weissleder R, Nahrendorf M. Eur Heart J. 2015 Jun 14;36(23):1478-88. doi: 10.1093/eurheartj/ehu225. Epub 2014 Jun 20. PMID: 24950695 

 

Data-driven estimation of cardiac electrical diffusivity from 12-lead ECG signals. 

Zettinig O, Mansi T, Neumann D, Georgescu B, Rapaka S, Seegerer P, Kayvanpour E, Sedaghat-Hamedani F, Amr A, Haas J, Steen H, Katus H, Meder B, Navab N, Kamen A, Comaniciu D. Med Image Anal. 2014 Dec;18(8):1361-76. doi: 10.1016/j.media.2014.04.011. Epub 2014 Apr 26. PMID: 24857832