Kumari M, Evangelakos I, Deshpande A, De Jong K, Schmiedel N, Palacio-Escat N, Filho A, Frias-Soler RC, Klinke G, Roh HC, Lange L, Berlin M, Fuh MM, Buss JJ, Tian T, Lerchenmǜller C, Freichel M, Schulze A, Nikolaev VO, Eschenhagen T, Rosen ED, Scheja L, Rangrez AY, Heeren J, Frey N. Activation of interferon signaling in cardiomyocytes via IRF3 impairs mitochondrial oxidative function through PGC-1α inhibition and drives heart failure. Nat Comm. 2026;17:2051

Deshpande A, Weirauch L, Baral TK, Steier M, Borlepawar B, Kumari M, Kilian LS, Richter K, Hammer E, Frank D, Schmidt C, Frey N, Rangrez AY. Elevated levels of Letm1 drives mitochondrial dysfunction and cardiomyocyte stress-mediated apoptosis in cultured cardiomyocytes. Cell Commun Signal. 2025;23(1):378.

Lanzer JD, Ramirez Flores RO, Liñares-Blanco J, Steier M, Rangrez AY, Frey N, Saez-Rodriguez J. A cross-study transcriptional patient map of heart failure defines conserved multicellular coordination in cardiac remodeling. Nat Comm. 2025;16(1):9659.

Neu M, Deshpande A, Borlepawar A, Hammer E, Ahlmadeen A, Vöcking P, Seeger T, Hausmann M, Frey N, Rangrez AY. TRIM24 regulates chromatin remodeling and calcium dynamics in cardiomyocytes. Cell Commun Signal. 2025;23(1):312.

Ma Z, Zuo T, Frey N, Rangrez AY. A systematic framework for understanding the microbiome in human health and disease: from basic principles to clinical translation. Signal Transduct Target Ther. 2024:9(1):237.

Rangrez AY, Frey N. Reverse cardio-oncology: is heart failure-mediated gut dysbiosis the mechanistic driver of colorectal cancer progression? Cardiovasc Res. 2024:120(6):561-562 

Lerchenmüller C, Vujic A, Mittag S, Wang A, Rabolli CP, Heß C, Betge F, Rangrez AY, Chaklader M, Guillermier C, Gyngard F, Roh JD, Li H, Steinhauser ML, Frey N, Rothermel B, Dieterich C, Rosenzweig A, Lee RT. Restoration of Cardiomyogenesis in Aged Mouse Hearts by Voluntary Exercise. Circulation. 2022:146(5):412-426

Spehlmann ME, Dhotre DP, Schmiedel N, Chavan N, Bang C, Rangrez AY. Dataset of Ileum Bacterial Diversity in Mice after Heart Failure due to Pressure Overload. Data in Brief. 2022: 44:108498

Spehlmann ME, Rangrez AY, Dhotre DP, Schmiedel N, Chavan N, Bang C, Müller OJ, Shouche YS, Franke A, Frank D, Frey N. Heart Failure Severity Closely Correlates with Intestinal Dysbiosis and Subsequent Metabolomic Alterations. Biomedicines. 2022:10(4):809

Deshpande, A., Borlepawar A., Rosskopf, A., Frank, D., Frey, N., Rangrez, AY., SH3-Binding Glutamic Acid Rich-Deficiency Augments Apoptosis in Neonatal Rat Cardiomyocytes. Int J Mol Sci, 2021. 22(20).

Kuhn C, Menke M, Senger F, Mack C, Dierck F, Hille S, Schmidt S, Brunke G, Bünger P, Schmiedel N, Will R, Sossalla S, Frank D, Eschenhagen T, Carrier L, Lüllmann-Rauch R, Rangrez AY, Frey N. FYCO1 regulates cardiomyocyte autophagy and prevents heart failure due to pressure overload in vivo. JACC Basic Transl Sci. 2021:6(4):365-380

Rangrez AY, Borlepawar A, Schmiedel N, Deshpande A, Remes A, Kumari M, Bernt A, Christen L, Helbig A, Jungmann A, Sossalla S, Tholey A, Müller OJ, Frank D, Frey N. The E3 ubiquitin ligase HectD3 attenuates cardiac hypertrophy and inflammation in mice. Commun Biol. 2020:3(1):562

Borlepawar A, Frey N, Rangrez AY.(2019) A systematic view on E3 ligase Ring TRIMmers with a focus on cardiac function and disease. Trends Cardiovasc Med. 2019;29:1-8. 

Müller OJ, Heckmann MB, Ding L, Rapti K, Rangrez AY, Gerken T, Christiansen N, Rennefahrt UEE, Witt H, Maldonado SG, Ternes P, Schwab DM, Ruf T, Hille S, Remes  A, Jungmann A, Weis TM, Kreußer J, Gröne HJ, Backs J, Schatz P, Katus HA, Frey N. Comprehensive plasma and tissue profiling reveals systemic metabolic alterations  in cardiac hypertrophy and failure. Cardiovasc Res. 2019:115(8):1296-1305

Borlepawar A, Rangrez AY, Bernt A, Christen L, Sossalla S, Frank D, Frey N. TRIM24 protein promotes and TRIM32 protein inhibits cardiomyocyte hypertrophy via regulation of dysbindin protein levels. J Biol Chem. 2017;292(24):10180-96.

Eden M, Meder B, Völkers M, Poomvanicha M, Domes C, Blanchereau M, Marck P, Will R, Bernt A, Rangrez A, Busch M, German Mouse Clinic Consortium, Heymes C, Rottbauer W, Most P, Hofmann F, Frey N. Myoscape, a novel protein expressed in the heart, controls cardiac calcium cycling and contractile function via regulation of L-type Calcium Channel surface expression. Nat Comm. 2016;7:11317.

Rangrez AY, Bernt A, Poyanmehr R, Harazin V, Boomgaarden I, Kuhn C, Rohrbeck A, Frank D, Frey N. Dysbindin is a potent inducer of RhoA-SRF-mediated cardiomyocyte hypertrophy. J Cell Biol. 2013;203(4):643-56.

Six I, Maizel J, Barreto FC, Rangrez AY, Dupont S, Slama M, Tribouilloy C, Choukroun G, Mazière JC, Bode-Boeger S, Kielstein JT, Drüeke TB, Massy ZA. Effects of phosphate on vascular function under normal conditions and influence of the uraemic state. Cardiovasc Res. 2012;96(1):130-9.

Kumari M, Schoiswohl G, Chitraju C, Paar M, Cornaciu I, Rangrez AY, Wongsiriroj N, Nagy HM, Ivanova PT, Scott SA, Knittelfelder O, Rechberger GN, Birner-Gruenberger R, Eder S, Brown HA, Haemmerle G, Oberer M, Lass A, Kershaw EE, Zimmermann R, Zechner R. Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase. Cell Metab. 2012;15(5):691-702.