Experimental Cardiology and Gut-Heart Axis

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Selected Publications

1. Deshpande A, Borlepawar A, Rosskopf A, Frank D, Frey N, Rangrez AY. SH3-Binding Glutamic Acid Rich-Deficiency Augments Apoptosis in Neonatal Rat Cardiomyocytes. Int J Mol Sci. 2021:22(20):11042
2. Kilian LS, Voran J, Frank D, Rangrez AY. RhoA: a dubious molecule in cardiac pathophysiology. J Biomed Sci. 2021:28(1):33
3. Kuhn C, Menke M, Senger F, Mack C, Dierck F, Hille S, Schmidt S, Brunke G, Bünger P, Schmiedel N, Will R, Sossalla S, Frank D, Eschenhagen T, Carrier L, Lüllmann-Rauch R, Rangrez AY, Frey N. FYCO1 regulates cardiomyocyte autophagy and prevents heart failure due to pressure overload in vivo. JACC Basic Transl Sci. 2021:6(4):365-380
4. Rangrez AY^#, Borlepawar A, Schmiedel N, Deshpande A, Remes A, Kumari M, Bernt A, Christen L, Helbig A, Jungmann A, Sossalla S, Tholey A, Müller OJ, Frank D, Frey N^#. The E3 ubiquitin ligase HectD3 attenuates cardiac hypertrophy and inflammation in mice. Commun Biol. 2020:3(1):562
5. Borlepawar A, Schmiedel N, Eden M, Christen L, Rosskopf A, Frank D, Lüllmann-Rauch R, Frey N, Rangrez AY^#. Dysbindin deficiency Alters Cardiac BLOC-1 Complex and Myozap Levels in Mice. Cells. 2020:9(11):2390
6. Frank D, Rangrez AY*, Friedrich C, Dittmann S, Stallmeyer B, Yadav P, Bernt A, Schelze-Bahr E, Borlepawar A, Zimmermann WH, Peischard S, Seebohm G, Linke WA, Baba HA, Krüger M, Unger A, Usinger P, Frey N, Schulze-Bahr, E. A cardiac α-actin (ACTC1) gene mutation causes atrial-septal defects associated with late-onset dilated cardiomyopathy. Circ Genom Precis Med. 2019:12(8):e002491.
7. Borlepawar A, Frey N, Rangrez AY^# (2019) A systematic view on E3 ligase Ring TRIMmers with a focus on cardiac function and disease. Trends Cardiovasc Med. 2019;29:1-8.
8. Müller OJ, Heckmann MB, Ding L, Rapti K, Rangrez AY, Gerken T, Christiansen N, Rennefahrt UEE, Witt H, Maldonado SG, Ternes P, Schwab DM, Ruf T, Hille S, Remes A, Jungmann A, Weis TM, Kreußer J, Gröne HJ, Backs J, Schatz P, Katus HA, Frey N. Comprehensive plasma and tissue profiling reveals systemic metabolic alterations in cardiac hypertrophy and failure. Cardiovasc Res. 2019:115(8):1296-1305
9. Rangrez AY, Eden M, Poyanmehr R, Kuhn C, Stiebeling K, Dierck F, Bernt A, Lüllmann-Rauch R, Weiler H, Kirchof P, Frank D, Frey N. Myozap Deficiency Promotes Adverse cardiac Remodeling via differential regulation of MAPK/SRF- and β-catenin/GSK-3β-signaling. J Biol Chem. 2016;291(8):4128-43.
10. Eden M, Meder B, Völkers M, Poomvanicha M, Domes C, Blanchereau M, Marck P, Will R, Bernt A, Rangrez A, Busch M, German Mouse Clinic Consortium, Heymes C, Rottbauer W, Most P, Hofmann F, Frey N. Myoscape, a novel protein expressed in the heart, controls cardiac calcium cycling and contractile function via regulation of L-type Calcium Channel surface expression. Nat Comm. 2016;7:11317.
11. Rangrez AY, Bernt A, Poyanmehr R, Harazin V, Boomgaarden I, Kuhn C, Rohrbeck A, Frank D, Frey N. Dysbindin is a potent inducer of RhoA-SRF-mediated cardiomyocyte hypertrophy. J Cell Biol. 2013;203(4):643-56.
12. Kumari M, Schoiswohl G, Chitraju C, Paar M, Cornaciu I, Rangrez AY, Wongsiriroj N, Nagy HM, Ivanova PT, Scott SA, Knittelfelder O, Rechberger GN, Birner-Gruenberger R, Eder S, Brown HA, Haemmerle G, Oberer M, Lass A, Kershaw EE, Zimmermann R, Zechner R. Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase. Cell Metab. 2012;15(5):691-702.