PD Dr. rer. nat. Ashraf Yusuf Rangrez
Arbeitsgruppenleiter/-in
(AG Experimental Cardiology and Gut-Heart Axis)
Ärztlicher / Beruflicher Werdegang
- seit 2021
Senior Group Leader, Department of Cardiology, Angiology and Pneumology, Universitätsklinikum Heidelberg, Germany
- 2017 – 2020
Group Leader, Department of Internal Medicine III (Cardiology, Angiology, Intensive Care Medicine), Universitätsklinikum Schleswig-Holstein Campus Kiel, Germany
- 2011 – 2016
Senior Post-doctoral fellow, Department of Internal Medicine III, Department of Internal Medicine III (Cardiology, Angiology, Intensive Care Medicine) Universitätsklinikum Schleswig-Holstein Campus Kiel, Germany
- 2010 – 2011
Post-doctoral fellow (INSERM), Faculty of Pharmacy and Medicine, Jules Verne University of Picardie, Amiens, France
- 2006 – 2009
Ph.D., National Centre for Cell Science in affiliation with University of Pune and partly at Technical University of Berlin (DAAD Sandwich Fellow)
- 2008 – 2009
DAAD Fellow (German Academic Exchange Service) “Sandwich Fellowship”, Technical University of Berlin as a part of PhD research work
- 2006 – 2007
Senior Research Fellow, National Centre for Cell Science, Pune, India
- 2004 – 2006
Junior Research Fellow, National Centre for Cell Science, Pune, India
- 2003 – 2004
Junior Scientist, Jubilant Biosys, Bangalore, India
Wissenschaftlicher Werdegang
- 2018
Habilitation and Venia Legendi, Christian-Albrechts-University Kiel, Germany
- 2011
Ph.D., National Centre for Cell Science in affiliation with University of Pune and partly at Technical University of Berlin (DAAD Sandwich Fellow)
- 2001 – 2003
Master of Science in Biochemistry, University of Pune, India
- 1998 – 2001
Bachelor of Science in Chemistry, University of Pune, India
Auszeichnungen
- 2014
Young Investigator Travel Grant from American Heart Association for Scientific Session
- 2014
Young Investigator Travel Grant from Basic Cardiovascular Society for BCVS
Stipendien
- Juni 2008 – Dezember 2009
DAAD (German Academic Exchange Service) Fellowship, Germany
- Juni 2007 – Mai 2008
Senior Research Fellowship, Council of Scientific and Industrial Research (CSIR), Govt of India
- August 2006 – Mai 2007
Senior Research Fellowship, Department of Biotechnology (DBT), Govt of India
- August 2004 – Juli 2006
Junior Research Fellowship, Department of Biotechnology (DBT), Govt of India
- Juni 2004
Employee of the month award in Jubilant Biosys for excellent performance
Qualified National Level GATE (Graduate Aptitude Test of Engineering) in “Life Sciences”, with 88.07%.
Simanthini-Jatkar Scholarship, a merit based scholarship given by Dept of Chemistry, University of Pune, during M.Sc.
Mitgliedschaften
German Centre for Cardiovascular Research (DZHK)
German Society of Cardiology (DGK)
European Society of Cardiology (ESC)
American Heart Association (AHA)
International Society of Heart Research (ISHR)
Forschungsschwerpunkte
E3 Ubiquitin ligases in the heart:
Ubiquitination is a primary step in UPS mediated protein turnover, which is accomplished by the concerted action of three enzymatic steps: ubiquitin activation via the enzyme E1, ubiquitin conjugation via E2 conjugating enzyme, and ubiquitin ligation by E3 ligases. Due to presence of over 600 with diverse structural properties, E3 ligases provide the substrate recognition specificity. Given the crucial role UPS plays in cardiac homeostasis, it is not surprising that several E3 enzymes have been implicated in various cardiac processes and pathologies like heart development, signaling cascades, ion channel regulation, autophagy regulation, protein degradation, congenital heart diseases and cardiomyopathies. We are actively working on deciphering the cardiac function of several E3 ligases.
Gut-heart axis:
The gut microbiome is known to play an essential role in regulating the host immune system, as well as in the pathogenesis of infections, obesity, auto-immune diseases and cancer. However, our knowledge of its putative role in human heart failure (HF), a leading cause of death in Germany and worldwide, is still limited and its therapeutic potential is under-explored. Hence, we here propose the concept of modulating gut microbial composition and/or its metabolic products with the goal of reducing systemic inflammation to ameliorate heart failure progression.
Personal- und Officemanagement Kardiologie, Angiologie, Pneumologie
Öffnungszeiten
| Mo – Do | 07:00 – 15:30 |
| Fr | 07:00 – 13:30 |
Sekretäre/-innen
-
Birgitta Hahn
Sekretärin
Schwerpunkt
Personal und Officemanagement (Oberärzte, Assistenzärzte); Koordination der Gastärzte, Famulanten, Praktikanten und der wissenschaftlichen und studentischen Hilfskräfte; Vertragsmanagement, Veranstaltungsmanagement
-
Marlena Wolf
Sekretärin
Schwerpunkt
Personal- und Officemanagement, Fortbildungsübersicht der Ärzte, Veranstaltungsmanagement, Terminkoordination,
Azubis, Doktoranden, Aushilfen (Herzkatheter)
