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Cardiac Proteostasis

We aim to understand age- and disease-linked changes in proteostasis (protein homeostasis) in the heart that underlie cardiac dysfunction and disease.


The overarching hypothesis that guides our research is that the levels and functions of key proteins in the heart are altered by cellular responses to age- and disease-linked changes in the intracellular environment that affect protein synthesis, protein folding, protein secretion, and protein degradation, i.e. protein homeostasis, and that these effects contribute to cardiac dysfunction. This hypothesis was developed as a result of our past and current research and it serves as the underpinning of our ongoing and future studies.

Funding from the German Center for Cardiovascular Research (Deutsche Zentrum für Herz-Kreislauf-Forschung e. V.; DZHK) provides support for our studies of protein stability in the heart.


These publications reflect our current interests:  

Doroudgar S, Völkers M, Thuerauf DJ, Khan M, Mohsin K, Wang W, Respress JL, Gude N, Müller OJ, Wehrens XHT, Sussman MA, Glembotski CC. (2015) Hrd1 is a Critical Element of the Sarcoplasmic/Endoplasmic Reticulum Quality Control in the Heart. Circ Res. 2015;117:536-546.
(Initiates file downloadlink to pdf)


A commentary on this article appears as follows:
Sun H, Gao C, Wang Y. A H(a)rd Way to Adapt in Cardiac Hypertrophy. (2015) Circ Res. 2015;117:484-486.
(Initiates file downloadlink to pdf)


Doroudgar S, Glembotski CC. (2013) New Concepts of Endoplasmic Reticulum Function in the Heart: Programmed to Conserve. J Mol Cell Cardiol. 2013 Feb;55:85-91.
(Initiates file downloadlink to pdf)


Doroudgar S, Glembotski CC. (2011) The Cardiokine Story Unfolds: Ischemic Stress-induced Protein Secretion in the Heart. Trends Mol Med. 17(4):207-14.
(Initiates file downloadlink to pdf)


Doroudgar S, Thuerauf DJ, Marcinko MC, Belmont PJ, Glembotski CC. (2009) Ischemia Activates the ATF6 Branch of the Endoplasmic Reticulum (ER) Stress Response. J. Biol. Chem. 284: 29735-29745.
(Initiates file downloadlink to pdf)



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Group Leader


Shirin Doroudgar, Ph.D.


Cardiac Proteostasis

University Hospital Heidelberg

Innere Medizin III

Im Neuenheimer Feld 669
69120 Heidelberg


Office Tel.:
+49 6221 56-34412

Lab Tel.:
+49 6221 56-37540

+49 6221 56-5372



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