- Arbeitsgruppen
- Klinisches Studienzentrum
- Sektion Kardio-Onkologie
- Section of Molecular and Translational Cardiology
- Klaus-Tschira-Institut für Computerkardiologie
- Heisenberg Professur für Immunkardiologie (W3)
- Jun. Professur für Künstliche Intelligenz in der Kardiovaskulären Medizin
- Pregnancy Heart Team: Kardiologie der Schwangerschaft
- DZHK-Standort Heidelberg/Mannheim
- Heidelberg CardioBiobank (HCB)
- Scientific Management and Coordination Unit (SMCU)
Publikationen
Publication list / Original research articles (2000 to 2019)
El-Battrawy I, Zhao Z, Lan H, Li X, Yücel G, Lang S, Sattler K, Schünemann JD, Zimmermann WH, Cyganek L, Utikal J, Wieland T, Bieback K, Bauer R, Ratte A, Pribe-Wolferts R, Rapti K, Nowak D, Wittig J, Thomas D, Most P, Katus HA, Ravens U, Schmidt C, Borggrefe M, Zhou XB, Müller OJ, Akin I.
Ion Channel Dysfunctions in Dilated Cardiomyopathy in Limb-Girdle Muscular Dystrophy.
Circ Genom Precis Med. 11(3):e001893, 2018
Lehmann LH, Jebessa ZH, Kreusser MM, Horsch A, He T, Kronlage M, Dewenter M, Sramek V, Oehl U, Krebs-Haupenthal J, von der Lieth AH, Schmidt A, Sun Q, Ritterhoff J, Finke D, Völkers M, Jungmann A, Sauer SW, Thiel C, Nickel A, Kohlhaas M, Schäfer M, Sticht C, Maack C, Gretz N, Wagner M, El- Armouche A, Maier LS, Londoño JEC, Meder B, Freichel M, Gröne HJ, Most P, Müller OJ, Herzig S, Furlong EEM, Katus HA, Backs J.
A proteolytic fragment of histone deacetylase 4 protects the heart from failure by regulating the hexosamine biosynthetic pathway.
Nat Med. 1, 62-72, 2018
Müller I, Vogl T, Pappritz K, Miteva K, Savvatis K, Rohde D, Most P, Lassner D, Pieske B, Kühl U, Van Linthout S, Tschöpe C.
Pathogenic Role of the Damage-Associated Molecular Patterns S100A8 and S100A9 in Coxsackievirus B3-Induced Myocarditis. Circ Heart Fail. 11, pii: e004125 2017 .
Kossack M, Hein S, Juergensen L, Siragusa M, Benz A, Katus HA, Most P*, Hassel D.
Induction of cardiac dysfunction in developing and adult zebrafish by chronic isoproterenol stimulation.
J Mol Cell Cardiol. 108, 95-105, 2017 (*co-corresponding and co-senior author)
Schlegel P, Reinkober J, Meinhardt E, Tscheschner H, Gao E, Schumacher SM, Yuan A, Backs J, Most P, Wieland T, Koch WJ, Katus HA, Raake PW.
G protein-coupled receptor kinase 2 promotes cardiac hypertrophy.
PLoS One. 12:e0182110, 2017
Lerchemüller C., Heißenberg J., Damilano F., Bezzeridis V.J., Krämer I., Bochaton-Piallat M.L., Hirschberg K., Busch M., Katus H.A., Peppel K., Rosenzweig A., Busch H., Börries M., Most P.
S100A6 regulates endothelial cell cycle progression by attenuating antiproliferative signal transducers and activators of transcription 1 signaling.
Arterioscler Thromb Vasc Biol, 39, 1854-1867, 2016
Eden M., Meder B., Völkers M., Poomvanicha M., Domes K., Branchereau M., Marck P., Will R., Bernt A., Rangez A., Hrabe de Angelis M., Heymes C., Rottbauer W., Most P., Hoffmann F., Frey N.
Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression.
Nature Communications, 7, 11317, 2016
Korkmaz-Icöz S, Al Said S, Radovits T, Li S, Brune M, Hegedűs P, Atmanli A, Ruppert M, Brlecic P, Lehmann LH, Lahrmann B, Grabe N, Yoshikawa Y, Yasui H, Most P, Karck M, Szabó G.
Oral treatment with a zinc complex of acetylsalicylic acid prevents diabetic cardiomyopathy in a rat model of type-2 diabetes: activation of the Akt pathway.
Cardiovasc Diabetol. 6, 15:75 2016
Rebbeck RT, Nitu FR, Rohde D, Most P, Bers DM, Thomas DD, Cornea RL.
S100A1 Protein Does Not Compete with Calmodulin for Ryanodine Receptor Binding but Structurally Alters the Ryanodine Receptor•Calmodulin Complex.Journal of Biological Chemistry, 291, 15896-907, 2016
Ritterhoff J., Völkers M., Seitz A., Spaich K., Gao E., Peppel K. Pleger S.T., Zimmermann W., Friederich O., Fink R., Koch W.J., Katus H.A., Most P.
S100A1 DNA-based inotropic therapy protects against proarrhythmogenic ryanodine receptor 2 dysfunction.
Molecular Therapy, 23, 1320-1330, 2015
Buss S., Krautz B., Hofmann N., Sander Y., Rust L., Giuca S., Galuschky C., Seitz S., Giannitsis E., Pleger S., Raake P., Most P., Katus H.A., Korosoglu G.
Prediction of functional recovery by cardiac magnetic resonance feature tracking imaging in first time ST-elevation myocardial infarction. Comparison to infarct size and transmurality by late gadolinium enhancement.
International Journal of Cardiology, 183, 162-170, 2015
Rohde D., Schön C., Börries M., Didrihisone I., Ritterhoff J., Kubatzky K.F., Völkers M., Herzog N., Mähler M., Tsoporis J., Parker T.G., Linke B., Giannitsis E., Gao E., Peppel K., Most, P.
S100A1 is released from ischemic cardiomyocytes and signals myocardial damage via Toll-like receptor 4.
EMBO Molecular Medicine, 6, 778-794, 2014
Friedrich O., Yi B., Edwards J., Reischl B., Wirth-Hücking A., Buttgereit A., Lang R., Weber C., Polyak F., Liu I., von Wegner F., Cully T., Lee A., Most P., Völkers M.
IL-1a reversibly inhibits skeletal muscle ryanodine receptor: a novel mechanism for critical illness myopathy.
Am J Respir Cell Mol Biol., 50, 1096-1106, 2014
Brinks H., Giraud M., Segiser A., Ferrie C., Longnus S., Ullrich N., Koch W.J., Most P., Carrel T.P. Tevaerai H. Dynamic patterns of ventricular remodelling and apoptosis in hearts unloaded by heterotopic transplantation.
J Heart Lung Transplantation, 33, 203-210, 2014
Weber C., Neascu I., Krautz B., Schlegel C., Sauer S., Raake P., Ritterhoff J., Jungmann A., Remppis A., Stangassinger M., Koch W.J., Katus H.A. Most P., Pleger S.T.
Therapeutic safety of high myocardial expression levels of the molecular inotrope S100A1 in a preclinical heart failure model.
Gene Therapy, 21, 131-138, 2014
Sen A., Most P., Peppel K.
Induction of microRNA-138 by proinflammatory cytokines causes endothelial dysfunction.
FEBS Letters, 518, 906-914, 2014
Sen A., Ren S., Lerchenmüller C., Sun J., Most P., Peppel K.
miRNA-138 regulates hypoxia-induced endothelial cell dysfunction by targeting S100A1. Plos One, 8, e78648, 2013
Most P., Lerchenmüller C., Rengo G., Mahlmann A., Ritterhoff J., Rohde D., Goodman C., Busch C.J., Laube F., Heissenberg J., Pleger S.T., Weiss N., Katus H.A., Koch W.J., Peppel K.
S100A1 deficiency impairs post-ischemic angiogenesis via compromised proangiogenic endothelial cell function and nitric oxide synthase regulation.
Circulation Research 112:66-78, 2013
Raake P.W.J., Schlegel P., Ksienzyk J., Reinkober J., Barthelmes J., Schinckel S., Pleger S.T., Mier W., Haberkorn U., Koch W.J., Katus H.A., *,#Most P., *Müller O.J.
AAV6-BARKct cardiac gene therapy ameliorates cardiac function and normalizes the catecholaminergic axis in a clinically relevant large animal heart failure model. (*shared last authorship and #corresponding authors) European Heart Journal, 34, 1437-1447, 2013
Raake P., Zhang X., Vinge L.E., Brinks H., Gao E., Jaleel N., Li Y., Tang M., Most P., Dorn G.W. 2nd, Houser S.R., Katus H.A., Chen X., Koch W.J.
Cardiac G-protein-coupled receptor kinase 2 ablation induces a novel Ca2+ handling phenotype resistant to adverse alterations and remodeling after myocardial infarction.
Circulation, 125, 2108-18, 2012
Völkers M., Dolatabadi N., Gude N., Most P., Sussman M.A., Hassel D.
Orai defieciency leads to heart failure and skeletal myopathy in zebrafish.
Journal of Cell Science, 125, 287-94, 2012
Pleger S.T., Shan C., Kszienzk J., Bekeredjian R., Boekstegers P., Hinkel R., Schinckel S., Leuchs B., Ludwig. J, Qiu G., Weber C., Raake P., Koch W.J., Katus H.A., Müller O.J., Most P.
Cardiac AAV9-S100A1 gene therapy rescues postischemic heart failure and reverses remodelling in a preclinical large animal model.
Science Translational Medicine, 3, 92ra64, 2011
Brinks H., Rohde D., Völkers M., Qiu G., Pleger S.T., Herzog N., Rabinowitz J., Ruhparwar A., Silvestry S., Lerchenmüller C., Mather P.J., Eckhart A.D., Katus H.A., Carrel T., Koch W.J., Most P. S100A1 genetically-targeted therapy reverses dysfunction of human failing cardiomyocytes. Journal of the American College of Cardiology, 58, 966-973, 2011
Völkers M., Weidenhammer C., Herzog N., Qiu G., Spaich K., v.Wegner F., Peppel K., Müller O., Schinkel S., Rabinowitz J., Hippe H.J., Brinks H., Katus H.A., Koch W.J., Eckhart A., Friedrich O., Most P. The inotropic peptide βARKct improves βAR Responsiveness in normal and failing cardiomyocytes-mediated L-type calcium current disinhibition.
Circulation Research, 108, 27-39, 2011
Völkers, M., Salz, M., Herzog, N., Frank, D., Dolatabati, N., Frey, N., Gude, N., Friedrich, O., Koch, W.J., Katus, H.A., Sussman, M.A., Most, P.
Orai1 and Stim-1 regulate normal and hypertrophic growth in cardiomyocytes. Journal of Molecular and Cellular Cardiology, 48, 1329-34, 2010
Brinks H., Boucher M., Gao E., Chuprun J.K., Pesant S., Raake P.W., Huang Z.M., Wang X., Qiu G., Gumpert A., Harris D.M., Eckhart A.D., Most P., Koch W.J.
Level of G protein-coupled receptor kinase-2 determines myocardial ischemia/reperfusion injury via pro- and anti-apoptotic mechanisms.
Circulation Research, 107, 1140-9, 2010
Luedde, M., Floegel, U., Knorr, M., Grundt, C., Hippe, H.J., Brors, B., Frank, D., Haselmann, U., Antony, C., Voelkers, M., Schrader, J., Most, P., Lemmer, B., Katus, H.A., Frey, N.
Decreased contractility due to energy deprivation in a transgenic rat model of hypertrophic cardiomyopathy.
Journal of Molecular Medicine, 87, 411-422, 2009
Harris, D.M., Chen, X., Pesant, S., Cohn, H.I., McDonnel, S.M., Boucher, M., Vinge, L.E., Raake, P., Moraca, S.R., Li, D., Most, P., Houser, R. H., Koch, W. J., Eckhart, A.D.
-adrenergic receptor mediated effects in a renal artery stenosis model of high blood pressure.
Journal of Cellular and Molecular Cardiology, 46, 100-107, 2009
deGeorge Jr., B., Rosenberg, M., Eckstein, V., Gao, E., Herzog, N., Katus, H.A., Koch, W.J., Frey, N.,
Most, P.
BMP-2 and FGF-2 synergistically facilitate adoption of a cardiac phenotype in somatic bone marrow
c-kit+/sca-1+ stem cells.
Clinical and Translational Science, 2, 116-125, 2008
Pleger, S.T., Harris, D.H., Shan, C., Vinge, L.E., Chuprun, J.K., Berzins, B., Pleger, W., Druckman, C., Voelkers, M., Heierhorst, J., Oie,. E, Remppis, A., Katus, H.A., Scalia, R., Eckhart, A.D. Koch, W.J., Most. P.
Endothelial S100A1 modulates vascular function via nitric oxide.
Circulation Research, 102, 786-794, 2008
Völkers, M., Loughrey, C.M., MacQuaide, N., Remppis, A., deGeorge, B., Koch, W.J., v.Wegner, F., Friederich, O., Katus, H.A., Fink, R.H.A., Smith, G.L., Most, P.
S100A1 decreases calcium spark frequency and alters their spatial characteristics in permeabilized ventricular cardiomyocytes.
Cell Calcium, 41, 135-143, 2007
Most, P.*, Börries, M.*, Gledhill, J.R., Walker, J.E., Katus, H.A., Koch, W.J., Ueli, A., Schoenenberger, C.A.
The Ca2+-dependent interaction of S100A1 with the F1-ATPase leads to an increased ATP content in cardiomyocytes.
Molecular and Cellular Biology, 27, 4365-4373, 2007 (*shared first authorship)
Pleger, S.T.*, Most, P.*, Boucher, M., Soltys, S., Chuprun, J.K., Pleger, W., Gao, E., Rengo, G., Remppis, A., Katus, H.A., Eckhart, A.D., Rabinowitz, J.E., Koch, W.J.
Stable myocardial specific AAV6-S100A1 gene therapy results in chronical functional heart failure rescue.
Circulation, 115, 2506-2515, 2007 (*shared first authorship)
Ehlermann, P., Eggers, K., Bierhaus, A., Most, P., Weichenhan, D., Greten, J., Nawroth, P.P., Katus, H.A., Remppis, A.
Increased proinflammatory endothelial response to S100A8/S100A9 after preactivation through advanced glycation end products.
Cardiovascular Diabetology, 5, 1-9, 2006 I
Most, P., Seifert, H., Gao, E.G., Funakoshi, H., Völkers, M., Heierhorst, J., Remppis, A., Pleger, S.T., deGeorge, B., Eckhart, A.D., Katus, H.A., Feldman, A.M., Koch, W.J.
Cardiac S100A1 protein levels determine contractile performance and propensity towards heart failure after myocardial infarction.
Circulation, 114, 1258-1268, 2006
Most, P.*, Pleger, S.T.*, Heidt, B., Völkers, M., Hata J.A., Katus, H.A., Remppis, A., Koch, W.J. S100A1 gene transfer to myocardium.
European Journal Medical Research, 11, 418-422, 2006 (*shared first authorship)
Pleger, S.T., Remppis, A., Heidt, B., Völkers, M., Gao, E., Chaprun, J.K., Szabo, G., Weichenhan, D., Müller, O., Eckhart, A.D., Katus, H.A., Koch, W.J., Most, P.
S100A1 gene therapy preserves in vivo cardiac function after myocardial infarction. Molecular Therapy, 12, 1120-1129, 2005
Most, P., Boerries, M., Eicher, C., Schweda, C., Völkers, M., Wedel, T., Söllner, S., Katus, H.A., Remppis, A., Aebi, U., Koch, W.J., Schoenenberger, C.
Distinct subcellular location of the Ca2+-binding protein S100A1 differentially modulates Ca2+-cycling in ventricular rat cardiomyocytes.
Journal of Cell Science, 118, 421-431, 2005
Liu, H.R., Gao, E., Hu, A., Tao, L., Qu, Y., Most, P., Koch, W.J., Christopher, T.A., Lopez, B.L., Alnemri, E.S., Zervos, A.S., Ma, X.L.
Role of Omi/HtrA2 in apoptotic cell death after myocardial ischemia and reperfusion. Circulation, 111, 90-96, 2004
Rottbauer, W., Just, S., Trano, N., Wessels, G., Most, P., Katus, H.A., Fishman, M.C. VEGF-
Genes and Development, 19, 1624-1634, 2005
Kettlewell, S.*, Most, P.*, Currie, S., Koch, W.J., Smith, G.L.
S100A1 increases the gain of excitation-contraction coupling in isolated rabbit ventricular
cardiomyocytes.
Journal of Molecular and Cellular Cardiology, 39, 900-910, 2005 (*shared first authorship)
Most, P., Pleger, S.T., Völkers, M., Heidt, B., Börries, M., Weichenhan, D., Löffler, E., Janssen, P.M.L., Williams, M.L., Katus, H.A., Remppis, A., Koch, W.J.
Cardiac adenoviral S100A1 gene delivery rescues failing myocardium. Journal of Clinical Investigation, 114, 1550-1563, 2004
Remppis, A., Pleger, S.T., Most, P., Lindenkamp, J., Ehlermann, P., Schweda, C., Löffler, E., Weichenhan, D., Zimmermann, W., Eschenhagen, T., Koch, W.J., Katus, H.A.
S100A1 gene transfer: A strategy to strengthen engineered cardiac grafts. Journal of Gene Medicine, 6, 387-394, 2004
Most, P., Börries, M., Eicher, C., Schweda, C., Löffler, E., Ehlermann, P., Pleger, S.T., Koch, W.J., Katus, H.A., Remppis, A.
Extracellular S100A1 protein inhibits apoptosis of ventricular rat cardiac myocytes via activation of the ERK1/2 pathway.
Journal of Biological Chemistry, 278, 48404-48412, 2003
Most, P., Remppis, A., Pleger, S.T., Loffler, E., Ehlermann, P., Bernotat, J., Kleuss, C., Heierhorst, J., Ruiz, P., Witt, H., Karczewski, P., Mao, L., Rockman, H.A., Duncan, S.J., Katus, H.A., Koch, W.J. Transgenic overexpression of the Ca2+ binding protein S100A1 in the heart leads to increased in vivo myocardial contractile performance.
Journal of Biological Chemistry, 278, 33809-33817, 2003
Most, P., Remppis, A., Weber, C., Bernotat, J., Ehlermann, P., Pleger, S.T., Kirsch, W., Weber, M., Uttenweiler, D., Smith, G.L., Katus, H.A., Fink, R.H.
The C-terminus (aa 75-94) and the linker region (aa 42-54) of the Ca2+ binding protein S100A1 differentially enhance sarcoplasmic Ca2+ release in murine skinned skeletal muscle fibres.
Journal of Biological Chemistry, 278, 26356-26364, 2003
Remppis, A., Most, P., Löffler, E., Ehlermann, P., Bernotat, J., Pleger, S., Börries, M., Reppel, M., Fischer, J., Koch, W.J., Smith, G.L., Katus, H.A.
The small EF-hand Ca2+ binding protein S100A1 increases contractility and Ca2+ cycling in rat cardiac myocytes.
Basic Res Cardiol 97, I/56-I/62, 2002
Most, P., Bernotat, J., Ehlermann, P., Pleger, S.T., Reppel, M., Börries, M., Niroomand, F., Pieske, B., Janssen, P.M.L., Eschenhagen, T., Karczewski, P., Smith, G.L., Koch, W.J., Katus, H.A., Remppis, A.
S100A1: A regulator of myocardial contractility. Proc Natl Acad Sci U S A, 98, 13889-13894, 2001
Remppis, A., Ehlermann, P., Giannitsis, E., Greten, T., Most, P., Müller-Bardorff, M., Katus, H.A. Cardiac Troponin T Levels at 96 Hours Reflect Myocardial Infarct Size: a Pathoanatomical Study. Cardiology, 93, 249-253, 2000
Ehlermann, P., Remppis, A., Most, P., Bernotat, J., Heizmann, C.W., Katus, H. A.
Purification of the Ca2+ binding protein S100A1 from myocardium and recombinant Escherichia coli.
J Chromatogr B Biomed Sci App, 737, 39-45, 2000
- Arbeitsgruppen
- Klinisches Studienzentrum
- Sektion Kardio-Onkologie
- Section of Molecular and Translational Cardiology
- Klaus-Tschira-Institut für Computerkardiologie
- Heisenberg Professur für Immunkardiologie (W3)
- Jun. Professur für Künstliche Intelligenz in der Kardiovaskulären Medizin
- Pregnancy Heart Team: Kardiologie der Schwangerschaft
- DZHK-Standort Heidelberg/Mannheim
- Heidelberg CardioBiobank (HCB)
- Scientific Management and Coordination Unit (SMCU)