- Arbeitsgruppen
- Klinisches Studienzentrum
- Sektion Kardio-Onkologie
- Section of Molecular and Translational Cardiology
- Klaus-Tschira-Institut für Computerkardiologie
- Heisenberg Professur für Immunkardiologie (W3)
- Jun. Professur für Künstliche Intelligenz in der Kardiovaskulären Medizin
- Pregnancy Heart Team: Kardiologie der Schwangerschaft
- DZHK-Standort Heidelberg/Mannheim
- Heidelberg CardioBiobank (HCB)
- Scientific Management and Coordination Unit (SMCU)
Publications
Selected publications
1. Dorothea Kehr, Julia Ritterhoff, Manuel Glaser, Lukas Jarosch, Rafael E. Salazar, Kristin Spaich, Karl Varadi, Jennifer Birkenstock, Michael Egger, Erhe Gao, Walter J. Koch, Hugo A. Katus, Norbert Frey, Andreas Jungmann, Cornelius Busch, Paul J. Mather, Arjang Ruhparwar, Mirko Völkers, Rebecca C. Wade, Patrick Most
S100A1ct: a synthetic peptide derived from S100A1 protein improves cardiac performance and survival in pre-clinical heart failure models
https://www.biorxiv.org/content/10.1101/2023.03.04.531024v1
BioRxiv, 2023. doi: doi.org/10.1101/2023.03.04.531024
2. Julia Ritterhoff, Mirko Völkers, Andreas Seitz, Kristin Spaich, Erhe Gao, Karsten Peppel, Sven T Pleger, Wolfram H Zimmermann , Oliver Friedrich, Rainer H A Fink, Walter J Koch, Hugo A Katus, Patrick Most
S100A1 DNA-based Inotropic Therapy Protects Against Proarrhythmogenic Ryanodine Receptor 2 Dysfunction.
Mol Ther. 2015 Aug;23(8):1320-1330. doi: 10.1038/mt.2015.93.
3. David Rohde, Christoph Schön, Melanie Boerries, Ieva Didrihsone, Julia Ritterhoff, Katharina F Kubatzky, Mirko Völkers, Nicole Herzog, Mona Mähler , James N Tsoporis, Thomas G Parker, Björn Linke, Evangelos Giannitsis, Erhe Gao, Karsten Peppel, Hugo A Katus, Patrick Most
S100A1 is released from ischemic cardiomyocytes and signals myocardial damage via Toll-like receptor 4.
EMBO Mol Med. 2014 Jun;6(6):778-94.doi: 10.15252/emmm.201303498.
4. Henriette Brinks, David Rohde, Mirko Voelkers, Gang Qiu, Sven T Pleger, Nicole Herzog, Joseph Rabinowitz, Arjang Ruhparwar, Scott Silvestry, Carolin Lerchenmüller, Paul J Mather, Andrea D Eckhart, Hugo A Katus, Thierry Carrel, Walter J Koch, Patrick Most
S100A1 genetically targeted therapy reverses dysfunction of human failing cardiomyocytes.
J Am Coll Cardiol. 2011 Aug 23;58(9):966-73. doi: 10.1016/j.jacc.2011.03.054.
5. Sven T Pleger, Changguang Shan, Jan Ksienzyk, Raffi Bekeredjian, Peter Boekstegers, Rabea Hinkel, Stefanie Schinkel, Barbara Leuchs, Jochen Ludwig, Gang Qiu, Christophe Weber, Philip Raake, Walter J Koch, Hugo A Katus, Oliver J Müller, Patrick Most
Cardiac AAV9-S100A1 gene therapy rescues post-ischemic heart failure in a preclinical large animal model.
Sci Transl Med. 2011 Jul 20;3(92):92ra64. doi: 10.1126/scitranslmed.3002097.
6. Patrick Most, Hanna Seifert, Erhe Gao, Hajime Funakoshi, Mirko Völkers, Jörg Heierhorst, Andrew Remppis, Sven T Pleger, Brent R DeGeorge Jr, Andrea D Eckhart, Arthur M Feldman, Walter J Koch
Cardiac S100A1 protein levels determine contractile performance and propensity toward heart failure after myocardial infarction.
Circulation. 2006 Sep 19;114(12):1258-68. doi: 10.1161/CIRCULATIONAHA.106.622415.
7. Patrick Most, Sven T Pleger, Mirko Völkers, Beatrix Heidt, Melanie Boerries, Dieter Weichenhan, Eva Löffler, Paul M L Janssen, Andrea D Eckhart, Jeffrey Martini, Matthew L Williams, Hugo A Katus, Andrew Remppis, Walter J Koch
Cardiac adenoviral S100A1 gene delivery rescues failing myocardium.
J Clin Invest. 2004 Dec;114(11):1550-63.doi: 10.1172/JCI21454.
A complete list of publications can be found here:
https://pubmed.ncbi.nlm.nih.gov/?term=%22Most%20P%22%20%5Bauthor%5D&sort=date
https://pubmed.ncbi.nlm.nih.gov/?term=%22ritterhoff+j%22+%5Bauthor%5D&sort=date
- Arbeitsgruppen
- Klinisches Studienzentrum
- Sektion Kardio-Onkologie
- Section of Molecular and Translational Cardiology
- Klaus-Tschira-Institut für Computerkardiologie
- Heisenberg Professur für Immunkardiologie (W3)
- Jun. Professur für Künstliche Intelligenz in der Kardiovaskulären Medizin
- Pregnancy Heart Team: Kardiologie der Schwangerschaft
- DZHK-Standort Heidelberg/Mannheim
- Heidelberg CardioBiobank (HCB)
- Scientific Management and Coordination Unit (SMCU)