Nachwuchsforschungsgruppe der Corona-Stiftung im Stifterverband

Laboratory for Cardio-Immunology

Translational Cardio-Immunology Research Group

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Mission

Cardiovascular diseases such as heart attack and stroke remain the leading cause of death worldwide. While the introduction of lipid-lowering, anti-hypertensive, and anti-thrombotic therapies have been unequivocally associated with improved outcomes, these approaches have been unable to displace cardiovascular disease from its title of the world's leading killer. 

Chief among the risk factor-independent drivers of cardiovascular disease seems to be inflammation. Thus, we aim to understand the mechanisms by which immune cells contribute to disease for a precise targeting of processes and inflammatory pathways. Our overarching goal is to heal chronic inflammation by harnessing immunotherapy.

Interested in learning more about our projects or joining the team?

Please reach out!

Contact

The Jarr Laboratory is located in:

Klaus Tschira Institute
Level 02
Im Neuenheimer Feld 669
69120 Heidelberg
Germany

Funding:

We gratefully acknowledge funding from current and previous sources.

 

Publications

Full publication list on PubMed.gov

2021 Jeffrey M. Hoeg Award Lecture: Defining the Role of Efferocytosis in Cardiovascular Disease: A Focus on the CD47 (Cluster of Differentiation 47) Axis.

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K. Jarr, Y. Kojima, I. Weissman, N. Leeper

Arteriosclerosis, Thrombosis and Vascular Biology, 2022

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The pleiotropic benefits of statins include the ability to reduce CD47 and amplify the effect of pro-efferocytic therapies in atherosclerosis

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K. Jarr, Jianqin Ye, Y. Kojima, Zhongde Ye, Hua Gao, Sofie Schmid, Lingfeng Luo, Richard A. Baylis, Mozhgan Lotfi, Nicolas Lopez, Anne V. Eberhard, Bryan R. Smith, I. Weissman, L. Maegdefessel, N. Leeper

Nature Cardiovascular Research, 2022

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Chitinase 3 like 1 (CHI3L1) is a regulator of smooth muscle cell physiology and atherosclerotic lesion stability.

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P. Tsantilas, Shen Lao, Zhiyuan Wu, Anne V. Eberhard, G. Winski, Monika Vaerst, V. Nanda, Ying Wang, Y. Kojima, Jianqin Ye, Alyssa M. Flores, K. Jarr, J. Pelisek, H. Eckstein, L. Matic, U. Hedin, P. Tsao, V. Paloschi, L. Maegdefessel, N. Leeper

Cardiovascular Research, 2021

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Effect of CD47 Blockade on Vascular Inflammation.

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K. Jarr, Ryusuke Nakamoto, Brandon H Doan, Y. Kojima, I. Weissman, R. Advani, A. Iagaru, N. Leeper

New England Journal of Medicine, 2021

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18F-Fluorodeoxyglucose-Positron Emission Tomography Imaging Detects Response to Therapeutic Intervention and Plaque Vulnerability in a Murine Model of Advanced Atherosclerotic Disease—Brief Report

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K. Jarr, Jianqin Ye, Y. Kojima, V. Nanda, Alyssa M. Flores, P. Tsantilas, Ying Wang, Niloufar Hosseini-Nassab, Anne V. Eberhard, Mozhgan Lotfi, Max Käller, B. Smith, L. Maegdefessel, N. Leeper

Arteriosclerosis, Thrombosis and Vascular Biology, 2020

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Clonally expanding smooth muscle cells promote atherosclerosis by escaping efferocytosis and activating the complement cascade

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Ying Wang, V. Nanda, D. Direnzo, Jianqin Ye, Sophia Xiao, Y. Kojima, K. Howe, K. Jarr, Alyssa M. Flores, P. Tsantilas, N. Tsao, Abhiram S. Rao, Alexandra A. C. Newman, Anne V. Eberhard, J. Priest, A. Ruusalepp, G. Pasterkamp, L. Maegdefessel, Clint L. Miller, L. Lind, Simon Koplev, J. Björkegren, G. Owens, E. Ingelsson, I. Weissman, N. Leeper

Proceedings of the National Academy of Sciences of the United States of America, 2020

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Knockout of the Murine Ortholog to the Human 9p21 Coronary Artery Disease Locus Leads to Smooth Muscle Cell Proliferation, Vascular Calcification, and Advanced Atherosclerosis.

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Y. Kojima, Jianqin Ye, V. Nanda, Ying Wang, Alyssa M. Flores, K. Jarr, P. Tsantilas, Liang Guo, A. Finn, R. Virmani, N. Leeper

Circulation, 2020

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Pro-efferocytic nanoparticles are specifically taken up by lesional macrophages and prevent atherosclerosis

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Alyssa M. Flores, Niloufar Hosseini-Nassab, K. Jarr, Jianqin Ye, Xingjun Zhu, R. Wirka, A. Koh, P. Tsantilas, Ying Wang, V. Nanda, Y. Kojima, Yitian Zeng, Mozhgan Lotfi, R. Sinclair, I. Weissman, E. Ingelsson, B. Smith, N. Leeper

Nature Nanotechnology, 2020

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Nanoparticle Therapy for Vascular Diseases

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Alyssa M. Flores, Jianqin Ye, K. Jarr, Niloufar Hosseini-Nassab, B. Smith, N. Leeper

Arteriosclerosis, Thrombosis and Vascular Biology, 2019

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Initial Single-Center Experience With the Fully Repositionable Transfemoral Lotus Aortic Valve System.

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K. Jarr, F. Leuschner, B. Meder, H. Katus, R. Bekeredjian, E. Chorianopoulos

The Journal of invasive cardiology, 2016

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Heat-shock-protein 90 protects from downregulation of HIF-1α in calcineurin-induced myocardial hypertrophy.

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Sabine Eschricht, K. Jarr, C. Kuhn, Lorenz L. Lehmann, M. Kreusser, H. Katus, N. Frey, E. Chorianopoulos

Journal of Molecular and Cellular Cardiology, 2015

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Inter- Not Intraindividual Differences in sTWEAK Levels Predict Functional Deterioration and Mortality in Patients with Dilated Cardiomyopathy

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K. Jarr, M. Nelles, H. Katus, E. Chorianopoulos

Mediators of Inflammation, 2014

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TNF-Like Weak Inducer of Apoptosis Aggravates Left Ventricular Dysfunction after Myocardial Infarction in Mice

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K. Jarr, Sabine Eschricht, L. Burkly, M. Preusch, H. Katus, N. Frey, E. Chorianopoulos

Mediators of Inflammation, 2014

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MicroRNA-20a inhibits stress-induced cardiomyocyte apoptosis involving its novel target Egln3/PHD3.

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D. Frank, J. Gantenberg, I. Boomgaarden, C. Kuhn, Rainer Will, K. Jarr, M. Eden, Kristina Kramer, M. Luedde, H. Mairbäurl, H. Katus, N. Frey

Journal of Molecular and Cellular Cardiology, 2012

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Soluble TWEAK is markedly upregulated in patients with ST-elevation myocardial infarction and related to an adverse short-term outcome.

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E. Chorianopoulos, K. Jarr, H. Steen, E. Giannitsis, N. Frey, H. Katus

Atherosclerosis, 2010