Kliniken &… Kliniken Zentrum für Innere… Innere Medizin III:… Forschung Arbeitsgruppen Grundlagenforschung … Molekulare… Publikationen


  1. Raake PW, Schlegel P, Weber C, Ksienzyk J, Huditz R, Barthelmes J,
    Schinkel S, Pleger S, Katus HA, Koch WJ, Most P, Müller OJ, AAV6.βARKct
    cardiac gene therapy rescues failing myocardium and normalizes the
    catecholaminergic axis in a clinically relevant large animal heart failure
    model (Eur Heart J. 2012).
  2. Raake PW, Chen C, Vinge LE, Brinks H, Gao E, Jaleel N, Li Y, Tang M,
    Most P, Katus HA, Dorn 2nd GW, Houser SR, Koch WJ. GRK2 Ablation in
    Cardiac Myocytes Enhances Excitation-Contraction Coupling and Inhibits
    Adverse Ca2+ Handling Remodeling in Heart Failure by Modulating the LType
    Ca2+ Channel (Circulation.2012).
  3. Harris DM, Chen X, Pesant S, Cohn HI, MacDonnell SM, Boucher M, Vinge
    LE, Raake P, Moraca SR, Li D, Most P, Houser SR, Koch WJ, Eckhart AD.
    Inhibition of angiotensin ii gq signaling augments beta-adrenergic receptor
    mediated effects in a renal artery stenosis model of high blood pressure. J
    Mol Cell Cardiol. 2009;46:100-107
  4. Raake PW, Hinkel R, Muller S, Delker S, Kreuzpointner R, Kupatt C, Katus
    HA, Kleinschmidt JA, Boekstegers P, Muller OJ. Cardio-specific long-term
    gene expression in a porcine model after selective pressure-regulated
    retroinfusion of adeno-associated viral (aav) vectors. Gene Ther.
  5. Vinge LE, Raake PW, Koch WJ. Gene therapy in heart failure. Circ Res.
  6. DeGeorge BR, Jr., Gao E, Boucher M, Vinge LE, Martini JS, Raake PW,
    Chuprun JK, Harris DM, Kim GW, Soltys S, Eckhart AD, Koch WJ. Targeted
    inhibition of cardiomyocyte gi signaling enhances susceptibility to apoptotic
    cell death in response to ischemic stress. Circulation. 2008;117:1378-1387
  7. Raake PW, Vinge LE, Gao E, Boucher M, Rengo G, Chen X, DeGeorge BR,
    Jr., Matkovich S, Houser SR, Most P, Eckhart AD, Dorn GW, 2nd, Koch WJ.
    G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or
    after myocardial infarction prevents heart failure. Circ Res. 2008;103:413-
  8. Martini JS, Raake P, Vinge LE, DeGeorge BR, Jr., Chuprun JK, Harris DM,
    Gao E, Eckhart AD, Pitcher JA, Koch WJ. Uncovering g protein-coupled
    receptor kinase-5 as a histone deacetylase kinase in the nucleus of
    cardiomyocytes. Proc Natl Acad Sci U S A. 2008;105:12457-12462
  9. Kupatt C, Hinkel R, von Bruhl ML, Pohl T, Horstkotte J, Raake P, El Aouni
    C, Thein E, Dimmeler S, Feron O, Boekstegers P. Endothelial nitric oxide
    synthase overexpression provides a functionally relevant angiogenic switch
    in hibernating pig myocardium. J Am Coll Cardiol. 2007;49:1575-1584
  10. Boekstegers P, Raake P, Hinkel R, Pohl T, Kupatt C, Knez A, Christ F, Eifert
    S, Steinbeck G, Reichart B, Vicol C. Hemodynamic and vascular effects of
    ventricular sourcing by stent-based ventricle to coronary artery bypass in
    patients with multivessel disease undergoing coronary artery bypass
    surgery. Circulation. 2005;112:I304-310
  11. Pfosser A, Raake P, Reithmann C, Behr J, Steinbeck G. [unusual infection
    with pulmonary round foci obtained through "Hay packs"]. Internist (Berl).
  12. Raake P, Hinkel R, Kupatt C, von Bruhl ML, Beller S, Andrees M, Vicol C,
    Boekstegers P. Percutaneous approach to a stent-based ventricle to
    coronary vein bypass (venous vpass): Comparison to catheter-based
    selective pressure-regulated retro-infusion of the coronary vein. Eur Heart J.
  13. Vicol C, Reichart B, Eifert S, Raake P, Hinkel R, Steinbeck G, Boekstegers
    P. First clinical experience with the vstent: A device for direct left ventricleto-
    coronary artery bypass. Ann Thorac Surg. 2005;79:573-579; discussion
  14. Kupatt C, Dessy C, Hinkel R, Raake P, Daneau G, Bouzin C, Boekstegers
    P, Feron O. Heat shock protein 90 transfection reduces ischemiareperfusion-
    induced myocardial dysfunction via reciprocal endothelial no
    synthase serine 1177 phosphorylation and threonine 495 dephosphorylation
    reperfusion-induced myocardial dysfunction via reciprocal endothelial no
    synthase serine 1177 phosphorylation and threonine 495 dephosphorylation.
    Arterioscler Thromb Vasc Biol. 2004;24:1435-1441
  15. Pohl T, Giehrl W, Reichart B, Kupatt C, Raake P, Paul S, Reichenspurner H,
    Steinbeck G, Boekstegers P. Retroinfusion-supported stenting in high-risk
    patients for percutaneous intervention and bypass surgery: Results of the
    prospective randomized myoprotect i study. Catheter Cardiovasc Interv.
  16. Raake P, von Degenfeld G, Hinkel R, Vachenauer R, Sandner T, Beller S,
    Andrees M, Kupatt C, Schuler G, Boekstegers P. Myocardial gene transfer
    by selective pressure-regulated retroinfusion of coronary veins: Comparison
    with surgical and percutaneous intramyocardial gene delivery. J Am Coll
    Cardiol. 2004;44:1124-1129
  17. Koczulla R, von Degenfeld G, Kupatt C, Krotz F, Zahler S, Gloe T,
    Issbrucker K, Unterberger P, Zaiou M, Lebherz C, Karl A, Raake P, Pfosser
    A, Boekstegers P, Welsch U, Hiemstra PS, Vogelmeier C, Gallo RL, Clauss
    M, Bals R. An angiogenic role for the human peptide antibiotic ll-37/hcap-18.
    J Clin Invest. 2003;111:1665-1672
  18. Kupatt C, Hinkel R, Vachenauer R, Horstkotte J, Raake P, Sandner T,
    Kreuzpointner R, Muller F, Dimmeler S, Feron O, Boekstegers P. Vegf165
    transfection decreases postischemic nf-kappa b-dependent myocardial
    reperfusion injury in vivo: Role of enos phosphorylation. Faseb J.
  19. Lebherz C, von Degenfeld G, Karl A, Pfosser A, Raake P, Pachmayr F,
    Scholz D, Kupatt C, Boekstegers P. Therapeutic angiogenesis/
    arteriogenesis in the chronic ischemic rabbit hindlimb: Effect of venous basic
    fibroblast growth factor retroinfusion. Endothelium. 2003;10:257-265
  20. von Degenfeld G et Raake P (contributed equally), Kupatt C, Lebherz C,
    Hinkel R, Gildehaus FJ, Munzing W, Kranz A, Waltenberger J, Simoes M,
    Schwaiger M, Thein E, Boekstegers P. Selective pressure-regulated
    retroinfusion of fibroblast growth factor-2 into the coronary vein enhances
    regional myocardial blood flow and function in pigs with chronic myocardial
    ischemia. J Am Coll Cardiol. 2003;42:1120-1128
  21. Boekstegers P et Raake P (contributed equally), Al Ghobainy R,
    Horstkotte J, Hinkel R, Sandner T, Wichels R, Meisner F, Thein E, March K,
    Boehm D, Reichenspurner H. Stent-based approach for ventricle-tocoronary
    artery bypass. Circulation. 2002;106:1000-1006
  22. Kupatt C, Wichels R, Deiss M, Molnar A, Lebherz C, Raake P, von
    Degenfeld G, Hahnel D, Boekstegers P. Retroinfusion of nfkappab decoy
    oligonucleotide extends cardioprotection achieved by cd18 inhibition in a
    preclinical study of myocardial ischemia and retroinfusion in pigs. Gene
    Ther. 2002;9:518-526
  23. Hoppensteadt DA, Fareed J, Raake P, Raake W. Endogenous release of
    tissue factor pathway inhibitor by topical application of an ointment
    containing mucopolysaccharide polysulfate to nonhuman primates. Thromb
    Res. 2001;103:157-163
  24. G protein-coupled receptor kinase 2 promotes cardiac hypertrophy.
    Schlegel P, Reinkober J, Meinhardt E, Tscheschner H, Gao E, Schumacher SM, Yuan A, Backs J, Most P, Wieland T, Koch WJ, Katus HA, Raake PW.
    PLoS One. 2017 Jul 31;12(7).
  25. Locally Targeted Cardiac Gene Delivery by AAV Microbubble Destruction in a Large Animal Model.
    Schlegel P, Huditz R, Meinhardt E, Rapti K, Geis N, Most P, Katus HA, Müller OJ, Bekeredjian R, Raake PW.
    Hum Gene Ther Methods. 2016 Apr;27(2):71-8.
  26. Therapeutic safety of high myocardial expression levels of the molecular inotrope S100A1 in a preclinical heart failure model.
    Weber C, Neacsu I, Krautz B, Schlegel P, Sauer S, Raake P, Ritterhoff J, Jungmann A, Remppis AB, Stangassinger M, Koch WJ, Katus HA, Müller OJ, Most P, Pleger ST.
    Gene Ther. 2014 Feb;21(2):131-8.