Raake PW, Schlegel P, Weber C, Ksienzyk J, Huditz R, Barthelmes J, Schinkel S, Pleger S, Katus HA, Koch WJ, Most P, Müller OJ, AAV6.βARKct cardiac gene therapy rescues failing myocardium and normalizes the catecholaminergic axis in a clinically relevant large animal heart failure model (Eur Heart J. 2012).
Raake PW, Chen C, Vinge LE, Brinks H, Gao E, Jaleel N, Li Y, Tang M, Most P, Katus HA, Dorn 2nd GW, Houser SR, Koch WJ. GRK2 Ablation in Cardiac Myocytes Enhances Excitation-Contraction Coupling and Inhibits Adverse Ca2+ Handling Remodeling in Heart Failure by Modulating the LType Ca2+ Channel (Circulation.2012).
Harris DM, Chen X, Pesant S, Cohn HI, MacDonnell SM, Boucher M, Vinge LE, Raake P, Moraca SR, Li D, Most P, Houser SR, Koch WJ, Eckhart AD. Inhibition of angiotensin ii gq signaling augments beta-adrenergic receptor mediated effects in a renal artery stenosis model of high blood pressure. J Mol Cell Cardiol. 2009;46:100-107
Raake PW, Hinkel R, Muller S, Delker S, Kreuzpointner R, Kupatt C, Katus HA, Kleinschmidt JA, Boekstegers P, Muller OJ. Cardio-specific long-term gene expression in a porcine model after selective pressure-regulated retroinfusion of adeno-associated viral (aav) vectors. Gene Ther. 2008;15:12-17
Vinge LE, Raake PW, Koch WJ. Gene therapy in heart failure. Circ Res. 2008;102:1458-1470
DeGeorge BR, Jr., Gao E, Boucher M, Vinge LE, Martini JS, Raake PW, Chuprun JK, Harris DM, Kim GW, Soltys S, Eckhart AD, Koch WJ. Targeted inhibition of cardiomyocyte gi signaling enhances susceptibility to apoptotic cell death in response to ischemic stress. Circulation. 2008;117:1378-1387
Raake PW, Vinge LE, Gao E, Boucher M, Rengo G, Chen X, DeGeorge BR, Jr., Matkovich S, Houser SR, Most P, Eckhart AD, Dorn GW, 2nd, Koch WJ. G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure. Circ Res. 2008;103:413- 422
Martini JS, Raake P, Vinge LE, DeGeorge BR, Jr., Chuprun JK, Harris DM, Gao E, Eckhart AD, Pitcher JA, Koch WJ. Uncovering g protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes. Proc Natl Acad Sci U S A. 2008;105:12457-12462
Kupatt C, Hinkel R, von Bruhl ML, Pohl T, Horstkotte J, Raake P, El Aouni C, Thein E, Dimmeler S, Feron O, Boekstegers P. Endothelial nitric oxide synthase overexpression provides a functionally relevant angiogenic switch in hibernating pig myocardium. J Am Coll Cardiol. 2007;49:1575-1584
Boekstegers P, Raake P, Hinkel R, Pohl T, Kupatt C, Knez A, Christ F, Eifert S, Steinbeck G, Reichart B, Vicol C. Hemodynamic and vascular effects of ventricular sourcing by stent-based ventricle to coronary artery bypass in patients with multivessel disease undergoing coronary artery bypass surgery. Circulation. 2005;112:I304-310
Pfosser A, Raake P, Reithmann C, Behr J, Steinbeck G. [unusual infection with pulmonary round foci obtained through "Hay packs"]. Internist (Berl). 2005;46:1152-1157
Raake P, Hinkel R, Kupatt C, von Bruhl ML, Beller S, Andrees M, Vicol C, Boekstegers P. Percutaneous approach to a stent-based ventricle to coronary vein bypass (venous vpass): Comparison to catheter-based selective pressure-regulated retro-infusion of the coronary vein. Eur Heart J. 2005;26:1228-1234
Vicol C, Reichart B, Eifert S, Raake P, Hinkel R, Steinbeck G, Boekstegers P. First clinical experience with the vstent: A device for direct left ventricleto- coronary artery bypass. Ann Thorac Surg. 2005;79:573-579; discussion 579
Kupatt C, Dessy C, Hinkel R, Raake P, Daneau G, Bouzin C, Boekstegers P, Feron O. Heat shock protein 90 transfection reduces ischemiareperfusion- induced myocardial dysfunction via reciprocal endothelial no synthase serine 1177 phosphorylation and threonine 495 dephosphorylation reperfusion-induced myocardial dysfunction via reciprocal endothelial no synthase serine 1177 phosphorylation and threonine 495 dephosphorylation. Arterioscler Thromb Vasc Biol. 2004;24:1435-1441
Pohl T, Giehrl W, Reichart B, Kupatt C, Raake P, Paul S, Reichenspurner H, Steinbeck G, Boekstegers P. Retroinfusion-supported stenting in high-risk patients for percutaneous intervention and bypass surgery: Results of the prospective randomized myoprotect i study. Catheter Cardiovasc Interv. 2004;62:323-330
Raake P, von Degenfeld G, Hinkel R, Vachenauer R, Sandner T, Beller S, Andrees M, Kupatt C, Schuler G, Boekstegers P. Myocardial gene transfer by selective pressure-regulated retroinfusion of coronary veins: Comparison with surgical and percutaneous intramyocardial gene delivery. J Am Coll Cardiol. 2004;44:1124-1129
Koczulla R, von Degenfeld G, Kupatt C, Krotz F, Zahler S, Gloe T, Issbrucker K, Unterberger P, Zaiou M, Lebherz C, Karl A, Raake P, Pfosser A, Boekstegers P, Welsch U, Hiemstra PS, Vogelmeier C, Gallo RL, Clauss M, Bals R. An angiogenic role for the human peptide antibiotic ll-37/hcap-18. J Clin Invest. 2003;111:1665-1672
Kupatt C, Hinkel R, Vachenauer R, Horstkotte J, Raake P, Sandner T, Kreuzpointner R, Muller F, Dimmeler S, Feron O, Boekstegers P. Vegf165 transfection decreases postischemic nf-kappa b-dependent myocardial reperfusion injury in vivo: Role of enos phosphorylation. Faseb J. 2003;17:705-707
Lebherz C, von Degenfeld G, Karl A, Pfosser A, Raake P, Pachmayr F, Scholz D, Kupatt C, Boekstegers P. Therapeutic angiogenesis/ arteriogenesis in the chronic ischemic rabbit hindlimb: Effect of venous basic fibroblast growth factor retroinfusion. Endothelium. 2003;10:257-265
von Degenfeld G et Raake P (contributed equally), Kupatt C, Lebherz C, Hinkel R, Gildehaus FJ, Munzing W, Kranz A, Waltenberger J, Simoes M, Schwaiger M, Thein E, Boekstegers P. Selective pressure-regulated retroinfusion of fibroblast growth factor-2 into the coronary vein enhances regional myocardial blood flow and function in pigs with chronic myocardial ischemia. J Am Coll Cardiol. 2003;42:1120-1128
Boekstegers P et Raake P (contributed equally), Al Ghobainy R, Horstkotte J, Hinkel R, Sandner T, Wichels R, Meisner F, Thein E, March K, Boehm D, Reichenspurner H. Stent-based approach for ventricle-tocoronary artery bypass. Circulation. 2002;106:1000-1006
Kupatt C, Wichels R, Deiss M, Molnar A, Lebherz C, Raake P, von Degenfeld G, Hahnel D, Boekstegers P. Retroinfusion of nfkappab decoy oligonucleotide extends cardioprotection achieved by cd18 inhibition in a preclinical study of myocardial ischemia and retroinfusion in pigs. Gene Ther. 2002;9:518-526
Hoppensteadt DA, Fareed J, Raake P, Raake W. Endogenous release of tissue factor pathway inhibitor by topical application of an ointment containing mucopolysaccharide polysulfate to nonhuman primates. Thromb Res. 2001;103:157-163
G protein-coupled receptor kinase 2 promotes cardiac hypertrophy. Schlegel P, Reinkober J, Meinhardt E, Tscheschner H, Gao E, Schumacher SM, Yuan A, Backs J, Most P, Wieland T, Koch WJ, Katus HA, Raake PW. PLoS One. 2017 Jul 31;12(7).
Locally Targeted Cardiac Gene Delivery by AAV Microbubble Destruction in a Large Animal Model. Schlegel P, Huditz R, Meinhardt E, Rapti K, Geis N, Most P, Katus HA, Müller OJ, Bekeredjian R, Raake PW. Hum Gene Ther Methods. 2016 Apr;27(2):71-8.
Therapeutic safety of high myocardial expression levels of the molecular inotrope S100A1 in a preclinical heart failure model. Weber C, Neacsu I, Krautz B, Schlegel P, Sauer S, Raake P, Ritterhoff J, Jungmann A, Remppis AB, Stangassinger M, Koch WJ, Katus HA, Müller OJ, Most P, Pleger ST. Gene Ther. 2014 Feb;21(2):131-8.
