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Neurologie und Poliklinik

Forschungsschwerpunkt Neuromyelitis optica

Diagnostische und pathophysiologische Relevanz von Autoantikörpern gegen Aquaporin-4

 

Projektleiter: Sven Jarius, Brigitte Wildemann 

 

Die Neuromyelitis-optica-Spektrum-Erkrankung (engl. neuromyelitis optica spectrum disorder, NMO/NMOSD, Devic-Syndrom) ist eine entzündliche Erkrankung des zentralen Nervensystems, die vornehmlich die Sehnerven und das Rückenmark betrifft und lange als Subtyp der Multiplen Sklerose galt. Schwerpunkt unserer Forschung sind Untersuchungen zur diagnostischen, prognostischen und pathophysiologischen Bedeutung von Autoantikörpern gegen das Wasserkanalprotein Aquaporin-4 (NMO-IgG/AQP4-AK) bei Patienten mit NMO oder verwandten Syndromen (longitudinal extensive transverse Myelitis, rekurrierende Optikusneuritis, Hirnstammenzephalitis) sowie die Entwicklung und Etablierung neuer, rekombinanter Testsysteme für den Nachweis von NMO-IgG/AQP4-AK.  

 

Der pathophysiologischen und diagnostischen Relevanz von Autoantikörpern bei anderen entzündlichen Erkrankungen des zentralen und/oder peripheren Nervensystems (MOG-Enzephalomyelitis, klassische Multiple Sklerose, paraneoplastische/idiopathische cerebelläre Ataxie, limbische Enzephalitis, periphere Neuropathien, Susac-Syndrom u.a.) sind eigenständige Projektbereiche gewidmet (MOG-Enzephalomyelitis; paraneoplastische und andere Auto-AK-assoziierte Syndrome).

 

Email-Adressen für Anfragen: 

sven.jarius@med.uni-heidelberg.de

brigitte.wildemann@med.uni-heidelberg.de

Ausgewählte Publikationen zum Thema

  • Asgari N, Jarius S, Laustrup H, Skejoe HP, Lillevang ST, Weinshenker BG, Voss A. Aquaporin-4-autoimmunity in patients with systemic lupus erythematosus: A predominantly population-based study. Mult Scler 2017; epub ahead of print (doi:10.1177/1352458517699791).
  • Gahlen A, Trampe AK, Haupeltshofer S, Ringelstein M, Aktas O, Berthele A, Wildemann B, Gold R, Jarius S, and Kleiter I. Aquaporin-4-antibodies in patients treated with natalizumab for suspected multiple sclerosis. Neurology: Neuroimmunology & Neuroinflammation 2017;4:e363.
  • Stellmann JP, Krumbholz M, Friede T, Gahlen A, Borisow N, Fischer K, Hellwig K, Pache F, Klemens R, Havla J, Kümpfel T, Aktas O, Hartung HP, Ringelstein M, Geis C, Kleinschnitz C, Berthele A, Hemmer B, Angstwurm K, Young KL, Schuster S, Stangel M, Lauda F, Tumani H, Mayer C, Zeltner L, Ziemann U, Linker RA, Schwab M, Marziniak M, Then Bergh F, Hofstadt-van Oy U, Neuhaus O, Zettl U, Faiss J, Wildemann B, Paul F, Jarius S, Trebst C, Kleiter I; on behalf of NEMOS (Neuromyelitis Optica Study Group). Immunotherapies in neuromyelitis optica spectrum disorder: Efficacy and predictors of response. JNNP 2017 Aug;88(8):639-647.
  • Reindl M, Jarius S, Rostasy K, Berger T. Myelin oligodendrocyte glycoprotein antibodies: How clinically useful are they? Curr Opin Neurol 2017 Jun;30(3):295-301.
  • Pache F, Wildemann B, Paul F, Jarius S. Neuromyelitis optica. Fortschr Neurol Psychiatr. 2017 Feb;85(2):100-114.
  • Jarius S, Ruprecht K, Kleiter I, Borisow N, Asgari N, Pitarokoili K, Pache F, Stich O, Beume L, Hümmert MW, Trebst C, Ringelstein M, Aktas O, Winkelmann A, Buttmann M, Schwarz A, Zimmermann H, Brandt AU, Franciotta D, Capobianco M, Kuchling J, Haas J, Korporal-Kuhnke M, Lillevang ST, Fechner K, Schanda K, Paul F*, Wildemann B*, Reindl M*. MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 1: Frequency, syndrome specificity, influence of disease activity, long-term course, association with AQP4-IgG, and origin. J Neuroinflammation 2016 Okt 26;13(1):279. Opens external link in new window[FREE PDF]
  • Jarius S, Ruprecht K, Kleiter I, Borisow N, Asgari N, Pitarokoili K, Pache F, Stich O, Beume L, Hümmert MW, Ringelstein M, Trebst C, Winkelmann A, Schwarz A, Buttmann M, Zimmermann H, Kuchling J, Franciotta D, Capobianco M, Siebert E, Lukas C, Korporal-Kuhnke M, Haas J, Fechner K, Brandt AU, Schanda K, Aktas O, Paul F*, Reindl M*, Wildemann B*. MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 2: Epidemiology, clinical presentation, radiological and laboratory features, treatment, and long-term outcome. J Neuroinflammation 2016 Okt 27;13(1):280. Opens external link in new window[FREE PDF]
  • Jarius S, Kleiter I, Ruprecht K, Asgari N, Pitarokoili K, Borisow N, Hümmert MW, Trebst C, Pache F, Winkelmann A, Beume LA, Ringelstein M, Stich O, Aktas O, Korporal-Kuhnke M, Schwarz A, Lukas C, Haas J, Fechner K, Buttmann M, Bellmann-Strobl J, Zimmermann H, Brandt AU, Franciotta D, Schanda K, Paul F*, Reindl M*, Wildemann B*. MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 3: Brainstem involvement – frequency, presentation and outcome. J Neuroinflammation 2016 Nov 1;13:281. Opens external link in new window[FREE PDF]
  • Pache F, Zimmermann H, Mikolajczak J, Schumacher S, Lacheta A, Oertel FC, Bellmann-Strobel J, Jarius S, Wildemann B, Reindl M, Waldman A, Soelberg K, Nasrin Asgari, Ringelstein M, Aktas O, Gross N, Buttmann M, Ach T, Ruprecht K, Paul F, Brandt AU. MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 4: Afferent visual system damage after optic neuritis in MOG-IgG-seropositive versus AQP4-IgG-seropositive patients. J Neuroinflammation 2016 Nov 1;13:282. Opens external link in new window[FREE PDF]
  • Borisow N, Kleiter I, Gahlen A, Fischer K, Wernecke KD, Pache F, Ruprecht K, Havla J, Krumbholz M, Kümpfel T, Aktas O, Ringelstein M, Geis C, Kleinschnitz C, Berthele A, Hemmer B, Angstwurm K, Weissert R, Stellmann JP, Schuster S, Stangel M, Lauda F, Tumani H, Mayer C, Zeltner L, Ziemann U, Linker RA, Schwab M, Marziniak M, Then Bergh F, Hofstadt-van Oy U, Neuhaus O, Winkelmann A, Marouf W, Rückriem L, Faiss J, Wildemann B, Paul F, Jarius S, Trebst C, Hellwig K; on behalf of NEMOS (Neuromyelitis Optica Study Group). Influence of female sex and fertile age on neuromyelitis optica spectrum disorders. Mult Scler 2017; Jul;23(8):1092-1103
  • Waters P, Reindl M, Saiz A, Schanda K, Tuller F, Kral V, Nytrova P, Sobek O, Nielsen HH, Barington T, Lillevang ST, Illes Z, Rentzsch K, Berthele A, Berki T, Granieri L, Bertolotto A, Giometto B, Zuliani L, Hamann D, van Pelt ED, Hintzen R, Höftberger R, Costa C, Comabella M, Montalban X, Tintoré M, Siva A, Altintas A, Deniz G, Woodhall M, Palace J, Paul F, Hartung HP, Aktas O, Jarius S, Wildemann B, Vedeler C, Ruiz A, Leite MI, Trillenberg P, Probst M, Saschenbrecker S, Vincent A, Marignier R. Multicentre comparison of a diagnostic assay: aquaporin-4 antibodies in neuromyelitis optica. J Neurol Neurosurg Psychiatry 2016 Sep;87(9):1005-15.
  • Ayzenberg I, Schollhammer J, Hoepner R, Hellwig K, Ringelstein M, Aktas O, Kümpfel T, Krumbholz M, Trebst C, Paul F, Pache F, Obermann M, Zeltner L, Schwab M, Berthele A, Jarius S, Kleiter I, on behalf of the Neuromyelitis Optica Study Group (NEMOS). Efficacy of glatiramer acetate in neuromyelitis optica spectrum disorder: a multicenter retrospective study. J Neurol 2016 Mar;263(3):575-82.
  • Metz I, Beißbarth T, Ellenberger D, Pache F, Stork L, Ringelstein M, Aktas O, Jarius S, Wildemann B, Dihazi H, Friede T, Brück W, Ruprecht K, Paul F. Serum peptide reactivities may distinguish neuromyelitis optica subgroups and multiple sclerosis. Neurology: Neuroimmunology & Neuroinflammation 2016 Feb 2;3(2):e204.
  • Kleiter I, Gahlen A, Borisow N, Fischer K, Wernecke K, Wegner B, Hellwig K, Pache F, Ruprecht K, Havla J, Krumbholz M, Kümpfel T, Aktas O, Hartung HP, Ringelstein M, Geis C, Kleinschnitz C, Berthele A, Hemmer B, Angstwurm K, Stellmann JP, Schuster S, Stangel M, Lauda F, Tumani H, Mayer C, Zeltner L, Ziemann U, Linker R, Schwab M, Marziniak M, ThenBergh F, Hofstadt-van Oy U, Neuhaus O, Winkelmann A, Marouf W, Faiss J, Wildemann B, Paul F, Jarius S, Trebst C, on behalf of the Neuromyelitis optica Study Group (NEMOS). Neuromyelitis optica: evaluation of 871 attacks and 1153 treatment courses. Ann Neurol 2016 Feb;79(2):206-16.
  • Keller A, Leidinger P, Meese E, Haas J, Backes C, Rasche L, Behrens JR, Pfuhl C, Wakonig K, Gieß RM, Jarius S, Meder B, Bellmann-Strobl J, Paul F, Pache FC, Ruprecht K. Next-generation sequencing identifies altered whole blood microRNAs in neuromyelitis optica spectrum disorder which may permit discrimination from multiple sclerosis. J Neuroinflammation 2015 Oct 31;12(1):196.
  • Jarius S, Aktas O, Wildemann B. Gamma-aminobutyric receptor agonists, aquaporin-4, and neuromyelitis optica: a potential link. Med Hypotheses 2015 Nov;85(5):628-30.
  • Jarius S, Wildemann B. Devic’s disease before Devic: Bilateral optic neuritis and simultaneous myelitis in a young woman (1874). J Neurol Sci 2015; Nov 15;358(1-2):419-21.
  • Wingerchuk DM, Banwell B, Bennett JL, Cabre P, Carroll W, Chitnis T, de Seze J, Fujihara K, Greenberg B, Jacob A, Jarius S, Lana-Peicoto M, Levy M, Simon JH, Tenembaum S, Traboulsee AL, Waters P, Wellik K, Weinshenker BG. International Consensus Diagnostic Criteria for Neuromyelitis Optica Spectrum Disorders. Neurology 2015 Jul 14;85(2):177-89.
  • Melamed E, Levy M, Waters PJ, Sato DK, Bennett JL, John GR, Hooper DC, Saiz A, Bar-Or A, Kim HJ, Pandit L, Leite MI, Asgari N, Kissani N, Hintzen R, Marignier R, Jarius S, Marcelletti J, Smith TJ, Yeaman MR, Han MH. Update on biomarkers in neuromyelitis optica. Neurol Neuroimmunol Neuroinflamm 2015 Jul 23;2(4):e134.
  • Krumbholz M, Hofstadt-van Oy U, Angstwurm K, Kleiter I, Jarius S, Paul F, Aktas O, Buchholz G, Kern P, Straube A, Kümpfel T. Very late-onset neuromyelitis optica spectrum disorder beyond the age of 75. J Neurol 2015 May;262(5):1379-84.
  • Harmel J, Ringelstein M, Ingwersen J, Mathys C, Goebels N, Hartung HP, Jarius S, Aktas O. Interferon-β-related tumefactive brain lesion in a Caucasian patient with neuromyelitis optica and clinical stabilization with tocilizumab. BMC Neurology 2014;14:247.
  • Jarius S, Paul F, Fechner K, Klemens R, Kleiter I, Franciotta D, Ringelstein M, Pache F, Aktas O, Wildemann B. Aquaporin-4 antibody testing: direct comparison of M1-AQP4-DNA-transfected cells with leaky scanning versus M23-AQP4-DNA-transfected cells as antigenic substrate. J Neuroinflammation 2014;11:129.
  • Ringelstein M, Aktas O, Harmel J, Prayer D, Jarius S, Wildemann B, Hartung HP, Salhofer-Polanyi S, Leutmezer F, Rommer PS. [Contribution of spinal cord biopsy in the differential diagnosis of longitudinal extensive transverse myelitis]. Nervenarzt 2014 Oct;85(10):1298-303.
  • Jarius S, Wildemann B, Paul F. Neuromyelitis optica: clinical features, immunopathogenesis and treatment. Clin Exp Immunol 2014 May;176(2):149-64.
  • Waters PJ, Pittock SJ, Bennett JL, Jarius S, Weinshenker BG, Wingerchuk DM. Evaluation of aquaporin-4 antibody assays. Clin Exp Neuroimmunol 2014 Oct;5(3):290–303.
  • Ringelstein M, Kleiter I, Ayzenberg I, Borisow N, Paul F, Ruprecht K, Kraemer M, Cohn E, Wildemann B, Jarius B, Hartung HP, Aktas O, Albrecht P. Visual evoked potentials in neuromyelitis optica and its spectrum disorders. Mult Scler 2014 Apr;20(5):617-20.
  • Levy M*, Wildemann B*, Jarius S*, Orellano B, Sasidharan S, Weber M, Stüve O. Immunopathogenesis of neuromyelitis optica. Adv Immunol 2014;121:213–242.
  • Jarius S, Wildemann B. 'Spinal amaurosis' (1841). On the early contribution of Edward Hocken to the concept of neuromyelitis optica. J Neurol 2014 Feb;261(2):400-4.
  • von Glehn F, Jarius S, Cavalcanti Lira RP, Alves Ferreira MC, Ribeiro von Glehn FH, Costa e Castro SM, Beltramini GC, Bergo FPG, Farias AS, Brandão CO, Wildemann B, Damasceno BP, Cendes F, Santos LMB, Yasuda CL. Structural brain abnormalities are related to retinal nerve fiber layer thinning and disease duration in neuromyelitis optica spectrum disorders. Mult Scler 2014 Aug;20(9):1189-97.
  • Trebst C, Jarius S, Berthele A, Paul F, Schippling S, Wildemann B, Borisow N, Kleiter I, Aktas O, Kümpfel T, Neuromyelitis Optica Study Group (NEMOS). Update on the diagnosis and treatment of neuromyelitis optica: Recommendations of the Neuromyelitis Optica Study Group (NEMOS). J Neurol 2014; Jan;261(1):1-16.
  • Jarius S, Wildemann B. Aquaporin-4 antibodies (NMO-IgG) as a serological marker of neuromyelitis optica: a critical review of the literature. Brain Pathol 2013 Nov;23(6):661-83. FREE PDF
  • Ringelstein M, Metz I, Ruprecht K, Koch A, Rappold J, Ingwersen J, Mathys C, Jarius S, Brück W, Hartung H-P, Paul F, Aktas O, for the Neuromyelitis Optica Study Group (NEMOS). Contribution of spinal cord biopsy to diagnosis of aquaporin-4 antibody positive neuromyelitis optica spectrum disorder. Mult Scler 2014 Jun;20(7):882-8.
  • Collongues N, Marignier R, Jacob A, Leite M, Siva A, Paul F, Zephir H, Akman-Demir G, Elsone L, Jarius S, Papeix C, Mutch K, Saip S, Wildemann B, Kitley J, Karabudak R, Aktas O, Kuscu D, Altintas A, Palace J, Confavreux C, De Seze J. Characterization of neuromyelitis optica and neuromyelitis optica spectrum disorder patients with a late onset. Mult Scler 2013 Dec 9;20(8):1086-1094.
  • Jarius S, Wildemann B. Aquaporin-4 antibodies, CNS acidosis and neuromyelitis optica: a potential link. Med Hypotheses 2013 Dec;81(6):1090-5.
  • Kremer L, Mealy M, Jacob A, Nakashima I, Cabre P, Bigi S, Paul F, Jarius S, Aktas O, Elsone L, Mutch K, Levy M, Takai Y, Collongues N, Banwell B, Fujihara K, de Seze J. Brainstem manifestations in neuromyelitis optica: a multicenter study of 258 patients. Mult Scler 2014 Jun;20(7):843-7.
  • Schmidt F, Goektas O, Jarius S, Wildemann B, Ruprecht K, Paul F, Harms L. Olfactory dysfunction in patients with neuromyelitis optica. Mult Scler Intern 2013, ID 654501.
  • Schneider E, Zimmermann H, Oberwahrenbrock T, Kaufhold F, Kadas EM, Petzold A, Bilger F, Borisow N, Jarius S, Wildemann B, Ruprecht K, Brandt AU, Paul F. Optical coherence tomography reveals distinct patterns of retinal damage in neuromyelitis optica and multiple sclerosis. PLoS One 2013 Jun 21;8(6):e66151.
  • Jarius S, Wildemann B. The history of neuromyelitis optica. J Neuroinflammation 2013 Jan 15;10:8.
  • Wildemann B, Jarius S, Paul F. [Neuromyelitis optica]. Nervenarzt 2013 Apr;84(4):436-41.
  • Jarius S, Wildemann B. An early British case of neuromyelitis optica (1850). BMJ 2012 Dec 22;345:e6430.
  • Jarius S, Lauda F, Wildemann B, Tumani H. Steroid-responsive hearing impairment in NMO-IgG/aquaporin-4-antibody-positive neuromyelitis optica. J Neurology 2013 Feb;260(2):663-4.
  • Jarius S, Paul F, Ruprecht K, Wildemann B. Low vitamin B12 levels and gastric parietal cell antibodies in patients with aquaporin-4 antibody-positive neuromyelitis optica spectrum disorders. J Neurology 2012;259(12):2743-5.
  • Jarius S, Franciotta D, Paul F, Bergamaschi R, Rommer PS, Ruprecht K, Ringelstein M, Aktas O, Kristoferitsch W, Wildemann B. Testing for antibodies to human aquaporin-4 by ELISA: Sensitivity, specificity, and direct comparison with immunohistochemistry. J Neurol Sci 2012 Sep 15;320(1-2):32-7.
  • Jarius S, Wildemann B. On the contribution of Thomas Clifford Allbutt, FRS, to the early history of neuromyelitis optica. J Neurol 2013 Jan;260(1):100-4.
  • von Glehn F, Jarius S, Penalva de Oliveira AC, Brandão CO, Farias AS, Damasceno A, Casseb J, Moraes AS, Longhini ALF, Wandinger KP, Damasceno DB, Wildemann B, Santos L. Aquaporin-4 antibodies are not related to HTLV-1 associated myelopathy. PLoS One 2012 Jul 10; 7(7):e39372.
  • Granieri L, Marnetto F, Valentino P, Frau J, Patanella AK, Nytrova P, Sola P, Capobianco M, Jarius S, Bertolotto A. Evaluation of a multiparametric immunofluorescence assay for standardization of neuromyelitis optica serology. PLoS One. 2012;7(6):e38896.
  • Sinnecker T, Dörr J, Pfueller CF, Harms L, Ruprecht K, Jarius S, Brück W, Niendorf T, Wuerfel J, Paul F. Distinct lesion morphology at 7T MRI differentiates neuromyelitis optica from multiple sclerosis. Neurology 2012 Aug 14;79(7):708-14.
  • Jarius S, Ruprecht K, Wildemann B, Kuempfel T, Ringelstein M, Geis C, Kleiter I, Kleinschnitz C, Berthele A, Brettschneider J, Hellwig K, Hemmer B, Linker R, Lauda F, Mayer CA, Tumani H, Melms A, Trebst C, Stangel M, Marziniak M, Hoffmann F, Schippling S, Faiss J, Neuhaus O, Ettrich B, Zentner C, Guthke K, Hofstadt-van Oy U, Reuss R, Pellkofer H, Ziemann U, Kern P, Wandinger KP, Then Bergh F, Boettcher T, Langel S, Liebetrau M, Rommer PS, Niehaus S, Münch C, Winkelmann A, Zettl U, Metz I, Veauthier C, Sieb JP, Wilke C, Hartung HP, Aktas O, Paul F. Contrasting disease patterns in seropositive and seronegative neuromyelitis optica. A multicentre study of 175 patients. J Neuroinflammation 2012; 9:14.
  • Wildemann B, Jarius S, Paul F. Neuromyelitis optica. Akt Neurol 2012 Jan; 39: 33-41.
  • Jarius S, Wildemann B. The case of the Marquis de Causan (1804): an early account of visual loss associated with spinal cord inflammation. J Neurol 2012 Jul; 259(7):1354-7.
  • Leite MI, Coutinho E, Lana-Peixoto M, Apostolos S, Waters P, Sato D, Melamud L, Marta M, Graham A, Spillane J, Villa AM, Callegaro D, Santos E, Martins da Silva A, Jarius S, Howard R, Nakashima I, Giovannoni G, Buckley C, Hilton-Jones D, Vincent A, Palace J. Myasthenia gravis and neuromyelitis optica spectrum disorder: A multicenter study of 16 patients. Neurology 2012 May 15;78(20):1601-7.
  • Jarius S, Paul F, Franciotta D, de Seze J, Münch C, Salvetti M, Ruprecht K, Liebetrau M, Wandinger KP, Akman-Demir G, Melms A, Kristoferitsch W, B Wildemann. Neuromyelitis optica spectrum disorders in patients with myasthenia gravis: ten new aquaporin-4 antibody positive cases and a review of the literature. Mult Scler 2012 Aug;18(8):1135-43.
  • Jarius S, Wandinger KP, Borowski K, Stoecker W, Wildemann B. Antibodies to CV2/CRMP5 in neuromyelitis optica-like disease: Case report and review of the literature. Clin Neurol Neurosurg 2012 May;114(4):331-5.
  • Mader S, Gredler V, Schanda K, Rostasy K, Dujmovic I, Pfaller K, Lutterotti A, Jarius S, Di Pauli F, Kuenz B, Ehling R, Hegen H, Deisenhammer F, Aboul-Enein F, Storch MK, Koson P, Drulovic J, Kristoferitsch W, Berger T, Reindl M. Complement activating antibodies to myelin oligodendrocyte glycoprotein in neuromyelitis optica and related disorders. J Neuroinflammation 2011 Dec 28;8:184
  • Jarius S, Wildemann B. 'Noteomielite' accompanied by acute amaurosis (1844). An early case of neuromyelitis optica. J Neurol Sci 2012 Feb;313(1–2):182–4.
  • Jarius S, Wildemann B. Effect of storage conditions and freeze/thaw cycles on aquaporin-4 antibody (NMO-IgG) serum levels. Clin Chem Lab Med 2011 Sep 21;49(12):2121-2.
  • Závada J, Nytrová P, Wandinger KP, Jarius S, Svobodová R, Probst C, Peterová V, Tegzová D, Pavelka K, and Vencovský J. Seroprevalence and specificity of NMO-IgG (anti-aquaporin 4 antibodies) in patients with neuropsychiatric systemic lupus erythematosus. Rheumat Int 2013 Jan;33(1):259-63; epub 29 Oct 2011.
  • Jarius S, Paul F, Franciotta D, Ruprecht K, Ringelstein M, Rommer P, Bergamaschi R, Kleiter I, Stich O, Reuss R, Rauer S, Zettl UK, Wandinger KP, Melms A, Aktas O, Kristoferitsch W, Wildemann B. Cerebrospinal fluid findings in aquaporin-4 antibody positive neuromyelitis optica: results from 211 lumbar punctures. J Neurol Sci 2011 July 15;360(1-2):82-90.
  • Jarius S, Jacobi C, de Seze J, Zephir H, Paul F, Franciotta D, Rommer P, Mader S, Kleiter I, Reindl M, Akman-Demir G, Seifert-Held T, Kristoferitsch W, Melms A, Wandinger KP, Wildemann B. Frequency and syndrome specificity of antibodies to aquaporin-4 in neurological patients with rheumatic disorders. Mult Scler 2011 Sep;17(9):1067-73.
  • Jarius S, Wildemann B. An early case of neuromyelitis optica: On a forgotten report by Jacob Lockhart Clarke, FRS. Mult Scler 2011 Nov;17(11):1384-6.
  • Trebst C, Berthele A, Jarius S, Kümpfel T, Schippling S, Wildemann B, Wilke C. Neuromyelitis optica Studiengruppe (NEMOS). [Diagnosis and treatment of neuromyelitis optica: Consensus recommendations of the Neuromyelitis Optica Study Group.] Nervenarzt 2011 Jun;82(6):768-77.
  • Jarius S, Wandinger KP, Platzer S, Wildemann B. Homology between Klebsiella pneumoniae and human aquaporin-4: no evidence for cross-reactivity in neuromyelitis optica. A study on 114 patients. J Neurol 2011 May;258(5):929-31.
  • Akman-Demir G, Tüzün E, Waters P, Içöz S, Kürtüncü M, Jarius S, Yapıcı Z, Mutlu M, Yeşilot N, Vincent A, Eraksoy M. Prognostic implications of aquaporin-4 antibody status in neuromyelitis optica patients. J Neurol 2011 Mar;258(3):464-70.
  • Jarius S, Frederikson J, Waters P, Paul F, Akman-Demir G, Marignier R, Franciotta D, Ruprecht K, Kuenz B, Rommer P, Kristoferitsch W, Wildemann B, Vincent A. Frequency and prognostic impact of antibodies to aquaporin-4 in patients with optic neuritis. J Neurol Sci 2010 Nov 15;298(1-2):158-62.
  • Editorial: Frequency and prognostic impact of antibodies to aquaporin-4 in patients with optic neuritis. Faculty of 1000 Prime, 19 Apr 2011 (DOI: 10.3410/f.9750956.10441054).
  • Jarius S, Franciotta D, Paul F, Ruprecht K, Bergamaschi R, Rommer PS, Reuss R, Probst C, Kristoferitsch W, Wandinger KP, Wildemann B. Cerebrospinal fluid antibodies to aquaporin-4 in neuromyelitis optica and related disorders: frequency, origin, and diagnostic relevance. J Neuroinflammation 2010 Sep 8;7:52.
  • Jarius S, Wildemann B. AQP4 antibodies in neuromyelitis optica: diagnostic and pathogenetic relevance. Nat Rev Neurol 2010 Jul;6(7):383-92.
  • Franciotta D, Di Stefano AL, Jarius S, Zardini E, Tavazzi E, Ballerini C, Marchioni E, Bergamaschi R, Ceroni M. Cerebrospinal BAFF and Epstein-Barr virus-specific oligoclonal bands in multiple sclerosis and other inflammatory demyelinating neurological diseases. J Neuroimmunol 2011 Jan;230(1-2):160-3.
  • Jarius S, Warth A, Wandinger KP, Schnabel PA, Hoffmann H, Wildemann B, Muley T. Antibodies to aquaporin-4 in non-small cell lung cancer: a study on 50 patients. Neurol Sci 2010 Dec;31(6):871-2;31:871-2.
  • Matiello M, Schaefer-Klein J, Brum DG, Atkinson EJ, Kantarci OH, Weinshenker BG; NMO genetics collaborators. HLA-DRB1*1501 tagging rs3135388 polymorphism is not associated with neuromyelitis optica. Mult Scler 2010 Aug;16(8):981-4.
  • Mader S, Lutterotti A, Di Pauli F, Kuenz B, Schanda K, Aboul-Enein F, Khalil M, Storch MK, Jarius S, Kristoferitsch W, Berger T, Reindl M. Patterns of antibody binding to aquaporin-4 isoforms in neuromyelitis optica. PLoS One 2010 May 5;5(5):e10455.
  • Jarius S, Franciotta D, Bergamaschi R, Wildemann B, Wandinger KP. Immunoglobulin M antibodies to aquaporin-4 in neuromyelitis optica and related disorders. Clin Chem Lab Med 2010 May;48(5):659-63.
  • Wandinger KP, Stangel M, Witte T, Venables P, Charles P, Jarius S, Wildemann B, Probst C, Iking-Konert C, Schneider M. Autoantibodies against aquaporin-4 in patients with neuropsychiatric systemic lupus erythematosus and primary Sjogren's syndrome. Arthritis Rheum 2010 Apr;62(4):1198-200.
  • Jarius S, Probst C, Borowski K, Franciotta D, Wildemann B, Stoecker W, Wandinger KP. Standardized method for the detection of antibodies to aquaporin-4 based on a highly sensitive immunofluorescence assay employing recombinant target antigen. J Neurol Sci 2010 Apr 15;291(1-2):52-6.
  • Reuss R, Rommer PS, Brück W, Jarius S, Bolz M, and Zettl UK. Anti-AQP4 ab might be relevant in pregnancy. BMJ 2010 Feb 8; reply
  • Reuss R, Rommer PS, Bruck W, Paul F, Bolz M, Jarius S, Boettcher T, Grossmann A, Bock A, Zipp F, Benecke R, Zettl UK. A woman with acute myelopathy in pregnancy: case outcome. BMJ 2009 Dec 10;339:b4026.
  • Reuss R, Rommer PS, Bruck W, Paul F, Bolz M, Jarius S, Boettcher T, Grossmann A, Bock A, Zipp F, Benecke R, Zettl UK. A woman with acute myelopathy in pregnancy: case progression. BMJ 2009 Nov 19;339:b4025.
  • Reuss R, Rommer PS, Bruck W, Paul F, Bolz M, Jarius S, Boettcher T, Grossmann A, Bock A, Zipp F, Benecke R, Zettl UK. A woman with acute myelopathy in pregnancy: case presentation. BMJ 2009 Nov 12;339:b3862.
  • Bergamaschi R, Jarius S, Robotti M, Pichiecchio A, Wildemann B, Meola G. Two cases of benign neuromyelitis optica in patients with celiac disease. J Neurol 2009 Dec;256(12):2097-9.
  • Jarius S, Aboul-Enein F, Waters P, Kuenz B, Hauser A, Berger T, Lang W, Reindl M, Vincent A, Kristoferitsch W. Antibody to aquaporin-4 in the long-term course of neuromyelitis optica. Brain 2008 Nov;131(Pt 11):3072-80.
  • Editorial: Antibody to aquaporin-4 in the long-term course of neuromyelitis optica. J Neurol. 2008;255:1990-1992.
  • Heerlein K, Jarius S, Jacobi C, Rohde S, Storch-Hagenlocher B, Wildemann B. Aquaporin-4 antibody positive longitudinally extensive transverse myelitis following varicella zoster infection. J Neurol Sci 2009 Jan 15;276(1-2):184-6.
  • Jarius S, Jacob S, Waters P, Jacob A, Littleton E, Vincent A. Neuromyelitis optica in patients with gluten sensitivity associated with antibodies to aquaporin-4. J Neurol Neurosurg Psychiatry 2008 Sep;79(9):1084.
  • Kay CS, Scola RH, Lorenzoni PJ, Jarius S, Arruda WO, Werneck LC. NMO-IgG positive neuromyelitis optica in a patient with myasthenia gravis but no thymectomy. J Neurol Sci 2008 Dec 15;275(1-2):148-50.
  • Waters P, Jarius S, Littleton E, Leite MI, Jacob S, Gray B, Geraldes R, Vale T, Jacob A, Palace J, Maxwell S, Beeson D, Vincent A. Aquaporin-4 antibodies in neuromyelitis optica and longitudinally extensive transverse myelitis. Arch Neurol 2008 Jul;65(7):913-9.
  • Paul F, Jarius S, Glumm R, Wildemann B, Zipp F, Aktas O. [Recent findings in pathogenesis, diagnostics and therapy of neuromyelitis optica]. Dtsch Med Wochenschr 2008 May;133(21):1125-9.
  • Jarius S, Paul F, Franciotta D, Waters P, Zipp F, Hohlfeld R, Vincent A, Wildemann B. Mechanisms of disease: aquaporin-4 antibodies in neuromyelitis optica. Nature Clin Pract Neurol 2008 Apr;4(4):202-14.
  • Jarius S, Franciotta D, Bergamaschi R, Rauer S, Wandinger KP, Petereit HF, Maurer M, Tumani H, Vincent A, Eichhorn P, Wildemann B, Wick M, Voltz R. Polyspecific, antiviral immune response distinguishes multiple sclerosis and neuromyelitis optica. J Neurol Neurosurg Psychiatry 2008 Oct;79(10):1134-6.
  • Editorial: MRZ reaction could distinguish patients with NMO from those with MS. Nature Clin Pract Neurol. 2008;4:524.
  • Franciotta D, Jarius S, Aloisi F. More on multiple sclerosis and neuromyelitis optica. Arch Neurol 2007 Dec;64(12):1802.
  • Jarius S, Wildemann B. [Neuromyelitis optica]. Nervenarzt. 2007 Dec;78(12):1365-77.
  • Jarius S, Paul F, Franciotta D, Wildemann B. Neuromyelitis optica. Curr Topics in Neuroimm 2007, p. 27-31.
  • Jarius S, Paul F, Franciotta D, Aktas O, Hohlfeld R, Zipp F, Vincent A. Revised diagnostic criteria for neuromyelitis optica-incorporation of NMO-IgG status. Nature Clin Pract Neurol 2007 May;3(5):E1.
  • Paul F*, Jarius S*, Aktas O, Bluthner M, Bauer O, Appelhans H, Franciotta D, Bergamaschi R, Littleton E, Palace J, Seelig HP, Hohlfeld R, Vincent A, Zipp F. Antibody to aquaporin 4 in the diagnosis of neuromyelitis optica. PLoS Med 2007 Apr;4(4):e133.
  • Jarius S, Franciotta D, Bergamaschi R, Wright H, Littleton E, Palace J, Hohlfeld R, Vincent A. NMO-IgG in the diagnosis of neuromyelitis optica. Neurology 2007 Mar 27;68(13):1076-7.
  • Kleiter I, Hellwig K, Berthele A, Kümpfel T, Linker RA, Hartung HP, Paul F, Aktas O; Neuromyelitis Optica Study Group. Failure of natalizumab to prevent relapses in neuromyelitis optica. Arch Neurol 2012 Feb;69(2):239-45.