Publications
We have published a series of major papers improving our understanding of neurological diseases. In 2015/2016, our department published more than 300 papers and top publications reaching the 3rd place (together with the department of Pharmacology) in the Heidelberg University Hospital publication ranking. Our most significant discoveries in 2019 include:
Berberich A, Kessler T, Thomé CM, Pusch S, Hielscher T, Sahm F, Oezen I, Schmitt LM, Ciprut S, Hucke N, Rübmann P, Fischer M, Lemke D, Breckwoldt MO, von Deimling A, Bendszus M, Platten M, Wick W. Targeting resistance against the MDM2 inhibitor RG7388 in glioblastoma cells by the MEK inhibitor trametinib. Clin Cancer Res. 2019 Jan 1;25(1):253-265
Berberich, A., C. Schneider, T. Reiff, C. Gumbinger and P. A. Ringleb (2019). Dual Antiplatelet Therapy Improves Functional Outcome in Patients With Progressive Lacunar Strokes. Stroke. 2019 Apr;50(4):1007-1009
Bruce C V Campbell*, Henry Ma*, Peter A Ringleb*, Mark W Parsons, Leonid Churilov, Martin Bendszus, Christopher R Levi, Chung Hsu, Timothy J Kleinig, Marc Fatar, Didier Leys, Carlos Molina, Tissa Wijeratne, …, Danilo Toni, Vincent Thijs, Werner Hacke†, Stephen M Davis†, Geoffrey A Donnan†, on behalf of the EXTEND, ECASS-4, and EPITHET Investigators‡. Extending thrombolysis to 4·5–9 h and wake-up stroke using perfusion imaging: a systematic review and meta-analysis of individual patient data. Lancet. 2019 Jul 13;394(10193):139-147
Campbell, B. C. V., H. Ma, P. A. Ringleb, M. W. Parsons, L. Churilov, M. Bendszus, C. R. Levi, C. Hsu, T. J. Kleinig, M. Fatar, D. Leys, C. Molina, T. Wijeratne, S. Curtze, H. M. Dewey, P. A. Barber, K. S. Butcher, D. A. De Silva, C. F. Bladin, N. Yassi, J. A. R. Pfaff, G. Sharma, A. Bivard, P. M. Desmond, S. Schwab, P. D. Schellinger, B. Yan, P. J. Mitchell, J. Serena, D. Toni, V. Thijs, W. Hacke, S. M. Davis and G. A. Donnan (2019). Extending thrombolysis to 4.5-9 h and wake-up stroke using perfusion imaging: a systematic review and meta-analysis of individual patient data. Lancet. 2019 Jul 13;394(10193):139-147
Hilf N, Kuttruff-Coqui S, Frenzel K, Bukur V, Stevanović S, Gouttefangeas C, Platten M, …, Rusch E, Bunse L, Song C, Heesch S, Wagner C, Kemmer-Brück A, Ludwig J, Castle JC, Schoor O, Tadmor AD, Green E, Fritsche J, Dietrich PY, Wick W. Actively personalized vaccination trial for newly diagnosed glioblastoma. Nature. 2019 Jan;565(7738):240-245
Jordan, B., S. Zierz, T. Weber and K. Jordan (2019). Successful use of an immune checkpoint inhibitor in a patient with myasthenia gravis in remission. Muscle Nerve. 2019 Jul;60(1):E7-E8
Kickingereder, P., F. Isensee, I. Tursunova, J. Petersen, U. Neuberger, D. Bonekamp, G. Brugnara, M. Schell, T. Kessler, M. Foltyn, I. Harting, F. Sahm, M. Prager, M. Nowosielski, A. Wick, M. Nolden, A. Radbruch, J. Debus, H. P. Schlemmer, S. Heiland, M. Platten, A. von Deimling, M. J. van den Bent, T. Gorlia, W. Wick, M. Bendszus and K. H. Maier-Hein (2019). Automated quantitative tumour response assessment of MRI in neuro-oncology with artificial neural networks: a multicentre, retrospective study. Lancet Oncol. 2019 May;20(5):728-740
Nowosielski, M., T. Gorlia, J. E. C. Bromberg, F. Sahm, I. Harting, P. Kickingereder, A. A. Brandes, M. J. B. Taphoorn, W. Taal, J. Domont, A. Idbaih, M. Campone, P. M. Clement, M. Weller, M. Fabbro, E. Le Rhun, M. Platten, V. Golfinopoulos, M. J. van den Bent, M. Bendszus and W. Wick. Imaging necrosis during treatment is associated with worse survival in EORTC 26101 study. Neurology. 2019 Jun 11;92(24):e2754-e2763
Schönenberger S, Weber D, Ungerer MN, Pfaff J, Schieber S, Uhlmann L, Heidenreich P, Bendszus M, Kieser M, Wick W, Möhlenbruch MA, Ringleb PA, Bösel J. The KEEP SIMPLEST Study: Improving In-House Delays and Periinterventional Management in Stroke Thrombectomy-A Matched Pair Analysis. Neurocrit Care. 2019 Aug;31(1):46-55
Stojic A, Bojcevski J, Williams SK, Bas-Orth C, Nessler S, Linington C, Diem R, Fairless R. Preclinical stress originates in the rat optic nerve head during development of autoimmune optic neuritis. Glia. 2019 Mar;67(3):512-524
Venkataramani V, Tanev DI, Strahle C, Studier-Fischer A, Fankhauser L, Kessler T, Körber C, Kardorff M, Ratliff M, Xie R, Horstmann H, Messer M, Paik SP, Knabbe J, Sahm F, Kurz FT, Acikgöz AA, Herrmannsdörfer F, Agarwal A, Bergles DE, Chalmers A, Miletic H, Turcan S, Mawrin C, Hänggi D, Liu HK, Wick W, Winkler F, Kuner T. Glutamatergic synaptic input to glioma cells drives brain tumour progression. Nature. 2019 Sep;573(7775):532-538
Wick W, Dettmer S, Berberich A, Kessler T, Karapanagiotou-Schenkel I, Wick A, Winkler F, Pfaff E, Brors B, Debus J, Unterberg A, Bendszus M, Herold-Mende C, Eisenmenger A, von Deimling A, Jones DTW, Pfister SM, Sahm F, Platten M. N2M2 (NOA-20) phase I/II trial of molecularly matched targeted therapies plus radiotherapy in patients with newly diagnosed non-MGMT hypermethylated glioblastoma. Neuro Oncol. 2019 Jan 1;21(1):95-105