Portrait von Dr. med. Marcin Zaradzki
Dr. med. Marcin Zaradzki, MHBA

Oberarzt (Klinik für Herzchirurgie)



Noormalal M, Schmiedel N, Bozoglu T, Matzen A, Hille S, Basha DI, Vijaya Shetty PM, Wolf A, Zaradzki M, Arif R, Pühler T, Lutter G, Wagner AH, Kupatt C, Frank D, Frey N, Remes A, Müller OJ (2023)

Regnase-1 overexpression as a therapeutic approach of Marfan syndrome.

Mol Ther Methods Clin Dev. 2023 Dec 1;32(1):101163. doi: 10.1016/j.omtm.2023.101163. eCollection 2024 Mar 14. PMID: 38178915 Free PMC article. 


Möbius A, Grieshaber P, Turra J, Riesterer D, Zaradzki M, Soso P, Hatiboglu G, Hohenfellner M, Warnecke G, Tochtermann U (2023)

Cavoatrial hypernephroma resection on cardiopulmonary bypass: Mild/normo-versus moderate hypothermia.

Perfusion. 2023 Nov;38(8):1644-1651. doi: 10.1177/02676591221128143. Epub 2022 Sep 20. PMID: 36125270 Free PMC article. 


Morath B, Meid AD, Zaradzki M, Geßele C, Nüse S, Chiriac U, Hoppe-Tichy T, Karck M, Soethoff J (2023)

Analysing and improving preoperative medication management in cardiac surgery.

Br J Clin Pharmacol. 2023 Apr;89(4):1349-1359. doi: 10.1111/bcp.15570. Epub 2022 Nov 15. PMID: 36256482



Zaradzki M, Mohr F, Lont S, Soethoff J, Remes A, Arif R, Müller OJ, Karck M, Hecker M, Wagner AH (2022)

Short-term rapamycin treatment increases life span and attenuates aortic aneurysm in a murine model of Marfan-Syndrome.

Biochem Pharmacol. 2022 Nov;205:115280. doi: 10.1016/j.bcp.2022.115280. Epub 2022 Oct 2. PMID: 36198355


Morath B, Meid AD, Zaradzki M, Geßele C, Nüse S, Chiriac U, Hoppe-Tichy T, Karck M, Soethoff J (2022)

Analysing and improving pre-operative medication management in cardiac surgery.

Br J Clin Pharmacol. 2022 Oct 18. doi: 10.1111/bcp.15570. Online ahead of print. PMID: 36256482


Mathies M, Krieg EM, Mohr F, Zaradzki M, Wagner AH (2022)

Effects of Rapamycin on the Expression of Redox Enzymes in Aortic Vascular Smooth Muscle Cells from Marfan Syndrome Mice.

Pharmacology. 2022;107(11-12):615-622.doi: 10.1159/000526624. Epub 2022 Sep 29.


Kallenbach K, Remes A, Müller OJ, Arif R, Zaradzki M, Wagner AH (2022)

Translational Medicine: Towards Gene Therapy of Marfan Syndrome.

J Clin Med. 2022 Jul 6;11(14):3934. doi: 10.3390/jcm11143934. PMID: 35887698 Free PMC article. Review.


Morath B, Sauer S, Zaradzki M, Wagner AH (2022)

Orodispersible films - Recent developments and new applications in drug delivery and therapy.

 Biochem Pharmacol. 2022 Jun;200:115036. doi: 10.1016/j.bcp.2022.115036. Epub 2022 Apr 12. PMID: 35427572 Review.



Morath B, Meid AD, Rickmann J, Soethoff J, Verch M, Karck M, Zaradzki M (2021)

Renal Safety of Hydroxyethyl starch 130/0.42 After Cardiac Surgery: A Retrospective Cohort Analysis.

Drug Saf. 2021 Dec;44(12):1311-1321.doi: 10.1007/s40264-021-01116-5. Epub 2021 Sep 26.


Remes A, Arif R, Franz M, Jungmann A, Zaradzki M, Puehler T, Md MBH, Frey N, Karck M, Kallenbach K, Hecker M, Müller OJ, Wagner AH (2021)

AAV-mediated AP-1 decoy oligonucleotide expression inhibits aortic elastolysis in a mouse model of marfan syndrome.

Cardiovasc Res. 2021 Nov 1;117(12):2459-2473.doi: 10.1093/cvr/cvab012.


Remes A, Basha DI, Puehler T, Borowski C, Hille S, Kummer L, Wagner AH, Hecker M, Soethoff J, Lutter G, Frank D, Arif R, Frey N, Zaradzki M, Müller OJ (2021)

Alginate hydrogel polymers enable efficient delivery of a vascular-targeted AAV vector into aortic tissue.

Mol Ther Methods Clin Dev. 2021 Feb 24;21:83-93. doi: 10.1016/j.omtm.2021.02.017. eCollection 2021 Jun 11. PMID: 33768132



Kummer L, Zaradzki M, Vijayan V, Arif R, Weigand MA, Immenschuh S, Wagner AH, Larmann J (2020)

Vascular Signaling in Allogenic Solid Organ Transplantation - The Role of Endothelial Cells.

Front Physiol. 2020 May 8;11:443. doi: 10.3389/fphys.2020.00443. eCollection 2020. PMID: 32457653


Remes A, Franz M, Zaradzki M, Borowski C, Frey N, Karck M, Kallenbach K, Müller OJ, Wagner AH, Arif R (2020)

AAV-mediated TIMP-1 overexpression in aortic tissue reduces the severity of allograft vasculopathy in mice.

J Heart Lung Transplant. 2020 Apr;39(4):389-398. doi: 10.1016/j.healun.2020.01.1338. Epub 2020 Jan 30.



Arif R, Franz M, Remes A, Zaradzki M, Hecker M, Karck M, Müller OJ, Kallenbach K, Wagner AH (2019)

Reduction of Transplant Vasculopathy by Intraoperative Nucleic Acid-based Therapy in a Mouse Aortic Allograft Model.

Thorac Cardiovasc Surg. 2019 Sep;67(6):503-512. doi: 10.1055/s-0038-1673633. Epub 2018 Oct 23.


Kremer J, Farag M, Zaradzki M, Szabó G, Ruhparwar A, Kallenbach K, Karck M, Arif R (2019)

The reimplantation valve-sparing aortic root replacement technique for patients with Marfan syndrome: A single-center experience.

Sci Rep. 2019 Aug 19;9(1):12021. doi: 10.1038/s41598-019-48572-9.


Wagner AH, Zaradzki M, Arif R, Remes A, Müller OJ, Kallenbach K (2019)

Marfan syndrome: A therapeutic challenge for long-term care.

Biochem Pharmacol. 2019 Jun;164:53-63. doi: 10.1016/j.bcp.2019.03.034. Epub 2019 Mar 27. Review.


Bhushan R, Altinbas L, Jäger M, Zaradzki M, Lehmann D, Timmermann B, Clayton NP, Zhu Y, Kallenbach K, Kararigas G, Robinson PN (2019)

An integrative systems approach identifies novel candidates in Marfan syndrome-related pathophysiology.

J Cell Mol Med. 2019 Apr;23(4):2526-2535. doi: 10.1111/jcmm.14137. Epub 2019 Jan 24.



Morath B, Green K, Zaradzki M, Heid J, Karck M, Hoppe-Tichy T (2018)

Subtherapeutic valproic acid plasma concentrations under concomitant dipyrone therapy in an epilepsy patient-a case report.

Eur J Clin Pharmacol. 2018 May;74(5):675-677. doi: 10.1007/s00228-018-2417-5. Epub 2018 Jan 23. No abstract available.



Arif R, Zaradzki M, Remes A, Seppelt P, Kunze R, Schröder H, Schwill S, Ensminger SM, Robinson PN, Karck M, Müller OJ, Hecker M, Wagner AH, Kallenbach K (2017)

AP-1 Oligodeoxynucleotides Reduce Aortic Elastolysis in a Murine Model of Marfan Syndrome.

Mol Ther Nucleic Acids. 2017 Dec 15;9:69-79. doi: 10.1016/j.omtn.2017.08.014. Epub 2017 Sep 20.



Arif R, Farag M, Zaradzki M, Reissfelder C, Pianka F, Bruckner T, Kremer J, Franz M, Ruhparwar A, Szabo G, Beller CJ, Karck M, Kallenbach K, Weymann A (2016)

Ischemic Colitis after Cardiac Surgery: Can We Foresee the Threat?

PLoS One. 2016 Dec 15;11(12):e0167601. doi: 10.1371/journal.pone.0167601. eCollection 2016.


Seppelt PC, Schwill S, Weymann A, Arif R, Weber A, Zaradzki M, Richter K, Ensminger S, Robinson PN, Wagner AH, Karck M, Kallenbach K (2016)

Loss of Endothelial Barrier in Marfan Mice (mgR/mgR) Results in Severe Inflammation after Adenoviral Gene Therapy.

PLoS One. 2016 Feb 3;11(2):e0148012. doi: 10.1371/journal.pone.0148012. eCollection 2016.