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Portrait von Dr. Sevil Korkmaz-İçöz, PhD

Priv. - Doz. Dr. Sevil Korkmaz-İçöz, PhD

Forschungsgruppenleiterin (Experimentelle Herzchirurgie)

Schwerpunkt

Myokardiale Ischämie und Reperfusion am Aortatransplantationsmodell, globale myokardiale Ischämie und Reperfusion am heterotopen Herztransplantationsmodell, diabetische Kardiomyopathie, Auswirkungen des Hirntodes auf die Myokard- und Endothelfunktion vor und nach Herz- und Aortatransplantation


Experimentelle Herzchirurgie

Auszeichnungen

Februar 2020

Forschungspreis Kardiovaskuläre Medizin der Deutsche Gesellschaft für Thorax-, Herz- und Gefäßchirurgie, Wiesbaden, Deutschland.

Februar 2017

Hans G. Borst-Preis 2017 („bestes Abstracts“) der Deutsche Gesellschaft für Thorax-, Herz- und Gefäßchirurgie, Leipzig, Deutschland. Zusammenarbeit mit Dr. med. Li.

Februar 2016

Ernst-Derra-Preis 2016 der Deutsche Gesellschaft für Thorax-, Herz- und Gefäßchirurgie, Leipzig, Deutschland

Juli 2014

Spitzenpublikationspreis der Medizinischen Fakultät Heidelberg

Januar 2014

“Carl S. Apstein Young Investigator Award”. Oral Presentation Award der “Cardiovascular Research Days”, Cortina d’Ampezzo, Italy

Juli 2013 – Juni 2013

Deutsches Zentrum für Herz-Kreislaufforschung -„Paper of the month - July“

Oktober 2010

Spitzenpublikationspreis der Medizinischen Fakultät Heidelberg

Oktober 2010 – September 2010

“Carl S. Apstein Young Investigator Award” der “Cardiovascular Research Days”, Weissensee, Austria

Stipendien

01. Oktober 2013 – 31. September 2015

Olympia Morata-Programm: Habilitationsstipendium der Medizinischen Fakultät Heidelberg.

2010 – 2012

Young Investigator Award: Postdoc-Programm der Medizinischen Fakultät Heidelberg. 

Arbeitsschwerpunkte

Myokardiale Ischämie und Reperfusion; diabetische Kardiomyopathie; Myokardinfarkt; vaskuläre Ischämie und Reperfusion
Linksventrikuläre Funktion, vaskuläre Funktionen, Endothelfunktion, oxidativer Stress; Molekularbiologie.

Drittmittel

April 2019 – März 2021

Klaus Tschira Stiftung, Projektnummer 00.008.2019, Hauptantragstellerin

Februar 2018 – Februar 2020

Deutsche Forschungsgemeinschaft (DFG), KO 4308/5-1

März 2017 – Juli 2019

Deutsche Stiftung für Herzforschung, F/20/16. Hauptantragstellerin

Oktober 2015 – September 2017

Ernst und Berta Grimmke – Stiftung, Lfd. Nr.5/15. Mitantragstellerin

September 2014 – September 2016

B. Braun Stiftung, Nr.BBST-D-14-00038. Mitantragstellerin

August 2013 – Juli 2015

Deutsche Stiftung für Herzforschung, F/05/13. Hauptantragstellerin

2012 – 2013

Forschungsstipendium der Deutschen Gesellschaft für Kardiologie – Herz- und Kreislaufforschung, (KOP/kar/Stip./DGK11/Korkmaz). Hauptantragstellerin

Publikationen

Publikationsliste, incl. Impactfaktor

 

2021

Veres G, Bai Y, Stark KA, Schmidt H, Radovits T, Loganathan S, Korkmaz-Icöz S, Szabó G (2021)

Pharmacological activation of soluble guanylate cyclase improves vascular graft function.

Interact Cardiovasc Thorac Surg. 2021 May 10;32(5):803-811. doi: 10.1093/icvts/ivaa329. PMID: 33515043

 

Korkmaz-Icöz S, Sun X, Li S, Brlecic P, Loganathan S, Ruppert M, Sayour AA, Radovits T, Karck M, Szabó G (2021)

Conditioned Medium from Mesenchymal Stem Cells Alleviates Endothelial Dysfunction of Vascular Grafts Submitted to Ischemia/Reperfusion Injury in 15-Month-Old Rats.

PLoS One. 2021 May 14;16(5):e0251829. doi: 10.1371/journal.pone.0251829. eCollection 2021. PMID: 33989335

 

Saemann L, Wenzel F, Kohl M, Korkmaz-Icöz S, Hoorn F, Loganathan S, Guo Y, Ding Q, Zhou P, Veres G, Karck M, Szabó G (2021)

Monitoring of perfusion quality and prediction of donor heart function during ex-vivo machine perfusion by myocardial microcirculation versus surrogate parameters.

J Heart Lung Transplant. 2021 May;40(5):387-391. doi: 10.1016/j.healun.2021.02.013. Epub 2021 Feb 22. PMID: 33726982

 

Korkmaz-Icöz S, Akca D, Li S, Loganathan S, Brlecic P, Ruppert M, Sayour AA, Simm A, Brune M, Radovits T, Karck M, Szabó G (2021)

Left-ventricular hypertrophy in 18-month-old donor rat hearts was not associated with graft dysfunction in the early phase of reperfusion after cardiac transplantation-gene expression profiling.

Geroscience. 2021 Apr 19. doi: 10.1007/s11357-021-00348-8. Online ahead of print. PMID: 33871784

 

Korkmaz-Icöz S, Zhou P, Guo Y, Loganathan S, Brlecic P, Radovits T, Sayour AA, Ruppert M, Veres G, Karck M, Szabó G (2021)

Mesenchymal stem cell-derived conditioned medium protects vascular grafts of brain-dead rats against in vitro ischemia/reperfusion injury.

Stem Cell Res Ther. 2021 Feb 24;12(1):144. doi: 10.1186/s13287-021-02166-3. PMID: 33627181

 

 

2020

Saemann L, Karck M, Korkmaz-Icöz S, Wenzel F, Szabó G (2020)

Ethical Decision Diagrams on Donation After Cardiocirculatory Death Heart Transplantation Considering Organ Preservation Techniques.

Transplant Direct. 2020 Oct 19;6(11):e617.doi: 10.1097/TXD.0000000000001075. eCollection 2020 Nov.

 

Korkmaz-Icöz S, Li K, Loganathan S, Ding Q, Ruppert M, Radovits T, Brlecic P, Sayour AA, Karck M, Szabó G (2020)

Brain-dead donor heart conservation with a preservation solution supplemented by a conditioned medium from mesenchymal stem cells improves graft contractility after transplantation.

Am J Transplant. 2020 Oct;20(10):2847-2856.doi: 10.1111/ajt.15843. Epub 2020 Apr 9.

 

Benke K, Németh BT, Sayour AA, Stark KA, Oláh A, Ruppert M, Szabó G, Korkmaz-Icöz S, Horváth EM, Benkő R, Hartyánszky I, Szabolcs Z, Merkely B, Radovits T (2020)

Stimulation of soluble guanylate cyclase improves donor organ function in rat heart transplantation.

Sci Rep. 2020 Mar 24;10(1):5358. doi: 10.1038/s41598-020-62156-y.

 

 

2019

Loganathan S, Guo Y, Jiang W, Radovits T, Ruppert M, Sayour AA, Brune M, Brlecic P, Gude P, Georgevici AI, Yard B, Karck M, Korkmaz-Icöz S, Szabó G (2019)

N-octanoyl dopamine is superior to dopamine in protecting graft contractile function when administered to the heart transplant recipients from brain-dead donors.

Pharmacol Res. 2019 Dec;150:104503.doi: 10.1016/j.phrs.2019.104503. Epub 2019 Oct 16.

 

Schmidt C, Wiedmann F, Beyersdorf C, Zhao Z, El-Battrawy I, Lan H, Szabo G, Li X, Lang S, Korkmaz-Icöz S, Rapti K, Jungmann A, Ratte A, Müller OJ, Karck M, Seemann G, Akin I, Borggrefe M, Zhou XB, Katus HA, Thomas D (2019)

Genetic Ablation of TASK-1 (Tandem of P Domains in a Weak Inward Rectifying K+ Channel-Related Acid-Sensitive K+ Channel-1) (K2P3.1) K+ Channels Suppresses Atrial Fibrillation and Prevents Electrical Remodeling.

Circ Arrhythm Electrophysiol. 2019 Sep;12(9):e007465. doi: 10.1161/CIRCEP.119.007465. Epub 2019 Sep 13.

 

Ruppert M, Korkmaz-Icöz S, Loganathan S, Jiang W, Oláh A, Sayour AA, Barta BA, Karime C, Merkely B, Karck M, Radovits T, Szabó G (2019)

Incomplete structural reverse remodeling from late-stage left ventricular hypertrophy impedes the recovery of diastolic but not systolic dysfunction in rats.

J Hypertens. 2019 Jun;37(6):1200-1212. doi: 10.1097/HJH.0000000000002042.

 

Sayour AA, Korkmaz-Icöz S, Loganathan S, Ruppert M, Sayour VN, Oláh A, Benke K, Brune M, Benko R, Horváth EM, Karck M, Merkely B, Radovits T, Szabó G (2019)

Acute canagliflozin treatment protects against in vivo myocardial ischemia-reperfusion injury in non-diabetic male rats and enhances endothelium-dependent vasorelaxation.

J Transl Med. 2019 Apr 16;17(1):127. doi: 10.1186/s12967-019-1881-8.

 

Ruppert M, Bódi B, Korkmaz-Icöz S, Loganathan S, Jiang W, Lehmann L, Oláh A, Barta BA, Sayour AA, Merkely B, Karck M, Papp Z, Szabó G, Radovits T (2019)

Myofilament Ca2+ sensitivity correlates with left ventricular contractility during the progression of pressure overload-induced left ventricular myocardial hypertrophy in rats.

J Mol Cell Cardiol. 2019 Apr;129:208-218. doi: 10.1016/j.yjmcc.2019.02.017. Epub 2019 Mar 4.

 

Korkmaz-Icöz S, Li S, Hüttner R, Ruppert M, Radovits T, Loganathan S, Sayour AA, Brlecic P, Lasitschka F, Karck M, Szabó G (2019)

Hypothermic perfusion of donor heart with a preservation solution supplemented by mesenchymal stem cells.

J Heart Lung Transplant. 2019 Mar;38(3):315-326. doi: 10.1016/j.healun.2018.12.003. Epub 2018 Dec 6.

 

Ruppert M, Korkmaz-Icöz S, Li S, Brlecic P, Németh BT, Oláh A, Horváth EM, Veres G, Pleger S, Grabe N, Merkely B, Karck M, Radovits T, Szabó G (2019)

Comparison of the Reverse-Remodeling Effect of Pharmacological Soluble Guanylate Cyclase Activation With Pressure Unloading in Pathological Myocardial Left Ventricular Hypertrophy.

Front Physiol. 2019 Jan 8;9:1869. doi: 10.3389/fphys.2018.01869. eCollection 2018.

 

2018

Korkmaz-Icöz S, Radovits T, Szabó G (2018)

Targeting phosphodiesterase 5 as a therapeutic option against myocardial ischaemia/reperfusion injury and for treating heart failure.

Br J Pharmacol. 2018 Jan;175(2):223-231. doi: 10.1111/bph.13749. Epub 2017 Mar 23.

 

Korkmaz-Icöz S, Szczesny B, Marcatti M, Li S, Ruppert M, Lasitschka F, Loganathan S, Szabó C, Szabó G (2018)

Olaparib protects cardiomyocytes against oxidative stress and improves graft contractility during the early phase after heart transplantation in rats.

Br J Pharmacol. 2018 Jan;175(2):246-261. doi: 10.1111/bph.13983. Epub 2017 Oct 2.

 

2017

Ruppert M, Korkmaz-Icöz S, Li S, Merkely B, Karck M, Radovits T, Szabó G (2017)

Reverse electrical remodeling following pressure unloading in a rat model of hypertension-induced left ventricular myocardial hypertrophy.

Hypertens Res. 2017 Jul;40(7):637-645. doi: 10.1038/hr.2017.1. Epub 2017 Jan 26.

 

Li S, Korkmaz-Icöz S, Radovits T, Ruppert M, Spindler R, Loganathan S, Hegedűs P, Brlecic P, Theisinger B, Theisinger S, Höger S, Brune M, Lasitscha F, Karck M, Yard B, Szabó G (2017)

Donor preconditioning after the onset of brain death with dopamine derivate n-octanoyl dopamine improves early posttransplant graft function in the rat.

Am J Transplant. 2017 Jul;17(7):1802-1812. doi: 10.1111/ajt.14207. Epub 2017 Feb 28.

 

2016

Müller AM, Bockstahler M, Hristov G, Weiß C, Fischer A, Korkmaz-Icöz S, Giannitsis E, Poller W, Schultheiss HP, Katus HA, Kaya Z (2016)

Identification of novel antigens contributing to autoimmunity in cardiovascular diseases.

Clin Immunol. 2016 Dec;173:64-75. doi: 10.1016/j.clim.2016.09.003. Epub 2016 Sep 12.

 

Korkmaz-Icöz S, Lehner A, Li S, Vater A, Radovits T, Brune M, Ruppert M, Sun X, Brlecic P, Zorn M, Karck M, Szabó G (2016)

Left ventricular pressure-volume measurements and myocardial gene expression profile in type 2 diabetic Goto-Kakizaki rats.

Am J Physiol Heart Circ Physiol. 2016 Oct 1;311(4):H958-H971. doi: 10.1152/ajpheart.00956.2015. Epub 2016 Aug 12

 

Ruppert M, Korkmaz-Icöz S, Li S, Németh BT, Hegedüs P, Brlecic P, Mátyás C, Zorn M, Merkely B, Karck M, Radovits T, Szabó G (2016)

Myocardial reverse remodeling after pressure unloading is associated with maintained cardiac mechanoenergetics in a rat model of left ventricular hypertrophy.

Am J Physiol Heart Circ Physiol. 2016 Sep 1;311(3):H592-603. doi: 10.1152/ajpheart.00085.2016. Epub 2016 Jun 24

 

Korkmaz-Icöz S, Al Said S, Radovits T, Li S, Brune M, Hegedűs P, Atmanli A, Ruppert M, Brlecic P, Lehmann LH, Lahrmann B, Grabe N, Yoshikawa Y, Yasui H, Most P, Karck M, Szabó G (2016)

Oral treatment with a zinc complex of acetylsalicylic acid prevents diabetic cardiomyopathy in a rat model of type-2 diabetes: activation of the Akt pathway.

Cardiovasc Diabetol. 2016 May 6;15(1):75. doi: 10.1186/s12933-016-0383-8.

 

Korkmaz-Icöz S, Atmanli A, Radovits T, Li S, Hegedüs P, Ruppert M, Brlecic P, Yoshikawa Y, Yasui H, Karck M, Szabó G (2015)

Administration of zinc complex of acetylsalicylic acid after the onset of myocardial injury protects the heart by upregulation of antioxidant enzymes.

J Physiol Sci. 2016 Mar;66(2):113-25. doi: 10.1007/s12576-015-0403-6. Epub 2015 Oct 23.

 

Hamon Y, Legowska M, Fergelot P, Dallet-Choisy S, Newell L, Vanderlynden L, Kord Valeshabad A, Acrich K, Kord H, Charalampos T, Morice-Picard F, Surplice I, Zoidakis J, David K, Vlahou A, Ragunatha S, Nagy N, Farkas K, Széll M, Goizet C, Schacher B, Battino M, Al Farraj Aldosari A, Wang X, Liu Y, Marchand-Adam S, Lesner A, Kara E, Korkmaz-Icöz S, Moss C, Eickholz P, Taieb A, Kavukcu S, Jenne DE, Gauthier F, Korkmaz B (2016)

Analysis of urinary cathepsin C for diagnosing Papillon-Lefèvre syndrome.

FEBS J. 2016 Feb;283(3):498-509. doi: 10.1111/febs.13605. Epub 2016 Jan 4.

 

Bangert A, Andrassy M, Müller AM, Bockstahler M, Fischer A, Volz CH, Leib C, Göser S, Korkmaz-Icöz S, Zittrich S, Jungmann A, Lasitschka F, Pfitzer G, Müller OJ, Katus HA, Kaya Z (2016)

Critical role of RAGE and HMGB1 in inflammatory heart disease.

Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):E155-64. doi: 10.1073/pnas.1522288113. Epub 2015 Dec 29.

 

Hegedűs P, Li S, Korkmaz-Icöz S, Radovits T, Mayer T, Al Said S, Brlecic P, Karck M, Merkely B, Szabó G (2016)

Dimethyloxalylglycine treatment of brain-dead donor rats improves both donor and graft left ventricular function after heart transplantation.

J Heart Lung Transplant. 2016 Jan;35(1):99-107. doi: 10.1016/j.healun.2015.06.016. Epub 2015 Jul 4.

 

2015

Li S, Korkmaz-Icöz S, Radovits T, Hegedűs P, Karck M, Szabó G (2015)

Comparison of donor hearts from hypoxic cardiac arrest followed by warm ischemia and from exsanguination as non-beating donor models in rat heart transplantation.

J Cardiothorac Surg. 2015 Dec 16;10 Suppl 1:A196. doi: 10.1186/1749-8090-10-S1-A196. Epub 2015 Dec 16

 

Weymann A, Patil NP, Sabashnikov A, Korkmaz S, Li S, Soos P, Ishtok R, Chaimow N, Pätzold I, Czerny N, Schmack B, Popov AF, Simon AR, Karck M, Szabo G (2015)

Perfusion-Decellularization of Porcine Lung and Trachea for Respiratory Bioengineering.

Artif Organs. 2015 Dec;39(12):1024-32. doi: 10.1111/aor.12481. Epub 2015 Apr 20

 

Korkmaz-Icöz S, Vater A, Li S, Lehner A, Radovits T, Hegedus P, Ruppert M, Brlecic P, Zorn M, Karck M, Szabó G (2015)

Mild type 2 diabetes mellitus improves remote endothelial dysfunction after acute myocardial infarction.

J Diabetes Complications. 2015 Nov-Dec;29(8):1253-60. doi: 10.1016/j.jdiacomp.2015.06.012. Epub 2015 Jul 2

 

Mátyás C, Németh BT, Oláh A, Hidi L, Birtalan E, Kellermayer D, Ruppert M, Korkmaz-Icöz S, Kökény G, Horváth EM, Szabó G, Merkely B, Radovits T (2015)

The soluble guanylate cyclase activator cinaciguat prevents cardiac dysfunction in a rat model of type-1 diabetes mellitus.

Cardiovasc Diabetol. 2015 Oct 31;14(1):145. doi: 10.1186/s12933-015-0309-x.

 

Loganathan S, Korkmaz-Icöz S, Radovits T, Li S, Mikles B, Barnucz E, Hirschberg K, Karck M, Szabó G (2015)

Effects of soluble guanylate cyclase activation on heart transplantation in a rat model.

J Heart Lung Transplant. 2015 Oct;34(10):1346-53. doi: 10.1016/j.healun.2015.05.006. Epub 2015 Jun 11

 

Korkmaz S, Atmanli A, Li S, Radovits T, Hegedus P, Barnucz E, Hirschberg K, Loganathan S, Yoshikawa Y, Yasui H, Karck M, Szabó G (2015)

Superiority of zinc complex of acetylsalicylic acid to acetylsalicylic acid in preventing postischemic myocardial dysfunction.

Exp Biol Med (Maywood). 2015 Sep;240(9):1247-55. doi: 10.1177/1535370215570184. Epub 2015 Feb 9

 

Korkmaz-Icöz S, Lehner A, Li S, Vater A, Radovits T, Hegedus P, Ruppert M, Brlecic P, Zorn M, Karck M, Szabó G (2015)

Mild Type 2 Diabetes Mellitus Reduces the Susceptibility of the Heart to Ischemia/Reperfusion Injury: Identification of Underlying Gene Expression Changes.

J Diabetes Res. 2015;2015:396414. Epub 2015 Jul 1

 

Sievers P, Uhlmann L, Korkmaz-Icöz S, Fastner C, Bea F, Blessing E, Katus HA, Preusch MR (2015)

Combined treatment with olmesartan medoxomil and amlodipine besylate attenuates atherosclerotic lesion progression in a model of advanced atherosclerosis.

Drug Des Devel Ther. 2015 Jul 29;9:3935-42. doi: 10.2147/DDDT.S85203. eCollection 2015.

 

Li S, Loganathan S, Korkmaz S, Radovits T, Hegedűs P, Zhou Y, Karck M, Szabó G (2015)

Transplantation of donor hearts after circulatory or brain death in a rat model.

J Surg Res. 2015 May 1;195(1):315-24. doi: 10.1016/j.jss.2014.12.038. Epub 2014 Dec 24

 

Veres G, Hegedűs P, Barnucz E, Zöller R, Klein S, Radovits T, Korkmaz S, Karck M, Szabó G (2015)

Graft preservation with heparinized blood/saline solution induces severe graft dysfunction.

Interact Cardiovasc Thorac Surg. 2015 May;20(5):594-600. doi: 10.1093/icvts/ivv010. Epub 2015 Feb 11.

 

Veres G, Hegedűs P, Barnucz E, Zöller R, Klein S, Schmidt H, Radovits T, Korkmaz S, Karck M, Szabó G (2015)

Endothelial Dysfunction of Bypass Graft: Direct Comparison of In Vitro and In Vivo Models of Ischemia-Reperfusion Injury.

PLoS One. 2015 Apr 15;10(4):e0124025. doi: 10.1371/journal.pone.0124025. eCollection 2015

 

Prall M, Lehmann HI, Prokesch H, Richter D, Graeff C, Kaderka R, Sonnenberg K, Hauswald H, Weymann A, Bauer J, Constantinescu A, Haberer T, Debus J, Szabó G, Korkmaz S, Durante M, Packer DL, Bert C (2015)

Treatment of arrhythmias by external charged particle beams: a Langendorff feasibility study.

Biomed Tech (Berl). 2015 Apr 1;60(2):147-56. doi: 10.1515/bmt-2014-0101.

 

Li S, Korkmaz S, Loganathan S, Radovits T, Hegedűs P, Karck M, Szabó G (2015)

Short- and long-term effects of brain death on post-transplant graft function in a rodent model.

Interact Cardiovasc Thorac Surg. 2015 Mar;20(3):379-86. doi: 10.1093/icvts/ivu403. Epub 2014 Dec 11

 

Radovits T, Korkmaz S, Mátyás C, Oláh A, Németh BT, Páli S, Hirschberg K, Zubarevich A, Gwanmesia PN, Li S, Loganathan S, Barnucz E, Merkely B, Szabó G (2015)

An altered pattern of myocardial histopathological and molecular changes underlies the different characteristics of type-1 and type-2 diabetic cardiac dysfunction.

J Diabetes Res. 2015;2015:728741. doi: 10.1155/2015/728741. Epub 2015 Jan 5.

 

2014

Hegedűs P, Korkmaz S, Radovits T, Schmidt H, Li S, Yoshikawa Y, Yasui H, Merkely B, Karck M, Szabó G (2014)

Bis (Aspirinato) Zinc (II) Complex Successfully Inhibits Carotid Arterial Neointima Formation after Balloon-injury in Rats.

Cardiovasc Drugs Ther. 2014 Dec;28(6):533-9. doi: 10.1007/s10557-014-6549-2

 

Weymann A, Patil NP, Sabashnikov A, Jungebluth P, Korkmaz S, Li S, Veres G, Soos P, Ishtok R, Chaimow N, Pätzold I, Czerny N, Schies C, Schmack B, Popov AF, Simon AR, Karck M, Szabo G (2014)

Bioartificial Heart: a human-sized porcine model - the way ahead.

PLoS One. 2014 Nov 3; 9(11): e111591. doi:10.1371/journal.pone.0111591

 

Weymann A*, Radovits T*, Schmack B, Korkmaz S, Li S, Chaimow N, Pätzold I, Becher PM, Hartyanszky I, Soos P, Merkely G, Nemeth BT, Istok R, Veres G, Merkely B, Terytze K, Karck M, Szabo G (2014)

Total aortic arch replacement: Superior ventriculo-arterial coupling with decellularized allografts compared with conventional prostheses.

PLoS One. 2014 Jul 31;9(7):e103588. doi: 10.1371/journal.pone.0103588. eCollection 2014.

 

Seyler C, Scherer D, Koepple C, Kulzer M, Korkmaz S, Thomas D, Kaya Z, Backs J, Katus H, Zitron E (2014)

P107Role of plasma membrane-associated AKAPs 15/18 and 79 for the regulation of cardiac IK1 current by protein kinase A.

Cardiovasc Res. 2014 Jul 15;103 Suppl 1:S18. doi: 10.1093/cvr/cvu082.48. Epub 2014 Jun 27

 

Matyas C, Korkmaz S, Olah A, Nemeth B, Hidi L, Birtalan E, Torok M, Merkely B, Szabo G, Radovits T (2014)

P765Diabetic cardiomyopathy: a comparative investigation in diabetic rat models.

Cardiovasc Res. 2014 Jul 15;103 Suppl 1:S140. doi: 10.1093/cvr/cvu098.184. Epub 2014 Jun 27

 

Nass N, Brömme HJ, Hartig R, Korkmaz S, Sel S, Hirche F, Ward A, Simm A, Wiemann S, Lykkesfeldt AE, Roessner A, Kalinski T (2014)

Differential Response to α-Axoaldehydes in Tamoxifen Resistant MCF-7 Breast Cancer Cells.

PLoS One. 2014 Jul 1;9(7):e101473. doi: 10.1371/journal.pone.0101473. eCollection 2014

 

Weymann A, Radovits T, Schmack B, Li S, Korkmaz S, Soós P, Istók R, Veres G, Chaimow N, Karck M, Szabó G (2014)

In Vitro Generation of Atrioventricular Heart Valve Neoscaffolds.

Artif Organs. 2014 Jul;38(7):E118-28. doi: 10.1111/aor.12321. Epub 2014 May 20.

 

Fischer F, Vonderlin N, Seyler C, Zitron E, Korkmaz S, Szabó G, Thomas D, Katus HA, Scholz EP (2014)

Isoenzyme-specific regulation of cardiac Kv1.5/Kvβ1.2 ion channel complex by protein kinase C: central role of PKCβII.

Naunyn Schmiedebergs Arch Pharmacol. 2014 May;387(5):469-76. doi: 10.1007/s00210-014-0965-5. Epub 2014 Feb 28

 

2013

Korkmaz S, Bährle-Szabó S, Loganathan S, Li S, Karck M, Szabó G (2013)

Marginal donors: can older donor hearts tolerate prolonged cold ischemic storage?

Aging Clin Exp Res. 2013 Oct;25(5):597-600. doi: 10.1007/s40520-013-0131-9. Epub 2013 Aug 15.

 

Veres G, Hegedüs P, Barnucz E, Zöller R, Radovits T, Korkmaz S, Kolonics F, Weymann A, Karck M, Szabo G. (2013)

Addition of Vardenafil into Storage Solution Protects the Endothelium in a Hypoxia-Reoxygenation Model.

Eur J Vasc Endovasc Surg. 2013 Aug;46(2):242-8. doi: 10.1016/j.ejvs.2013.05.006. Epub 2013 Jun 7.

 

Hirschberg K, Tarcea V, Páli S, Barnucz E, Gwanmesia PN, Korkmaz S, Radovits T, Loganathan S, Merkely B, Karck M, Szabó G (2013)

Cinaciguat prevents neointima formation after arterial injury by decreasing vascular smooth muscle cell migration and proliferation.

Int J Cardiol. 2013 Jul 31;167(2):470-7. doi: 10.1016/j.ijcard.2012.01.032. Epub 2012 Feb 20.

 

Korkmaz S, Zitron E, Bangert A, Seyler C, Li S, Hegedüs P, Scherer D, Li J, Fink T, Schweizer PA, Giannitsis E, Karck M, Szabó G, Katus HA, Kaya Z (2013)

Provocation of an autoimmune response to cardiac voltage-gated sodium channel NaV1.5 induces cardiac conduction defects in rats.

J Am Coll Cardiol. 2013 Jul 23;62(4):340-9. doi: 10.1016/j.jacc.2013.04.041. Epub 2013 May 15.

 

Radovits T, Arif R, Bömicke T, Korkmaz S, Barnucz E, Karck M, Merkely B, Szabó G (2013)

Vascular dysfunction induced by hypochlorite is improved by the selective phosphodiesterase-5-inhibitor vardenafil .

Eur J Pharmacol. 2013 Jun 15;710(1-3):110-9. doi: 10.1016/j.ejphar.2013.04.012. Epub 2013 Apr 23

 

Korkmaz S, Barnucz E, Li S, Radovits T, Hegedüs P, Radovits T, Zubarevich A, Hirschberg K, Weymann A, Puskás LG, Ózsvári B, Faragó N, Kanisai I, Fábián G, Gyuris M, Merkely B, Karck M, Szabó S, Szabó G (2013)

Q50, an iron-chelating and zinc-complexing agent, improves cardiac function in rat models of ischemia/reperfusion-induced myocardial injury.

Circ J. 2013;77(7):1817-26. Epub 2013 Apr 11.

 

Barnucz E, Veres G, Hegedus P, Klein S, Zoller R, Radovits T, Korkmaz S, Horkay F, Merkely B, Karck M, Szabo G (2013)

Prolyl-hydroxylase inhibition preserves endothelial cell function in a rat model of vascular ischemia reperfusion injury.

J Pharmacol Exp Ther. 2013 Apr;345(1):25-31. doi: 10.1124/jpet.112.200790. Epub 2013 Feb 6

 

Korkmaz S, Loganathan S, Mikles B, Radovits T, Barnucz E, Hirschberg K, Li S, Hegedüs P, Páli S, Weymann A, Karck M, Szabó G (2013)

Nitric Oxide- and Heme-Independent Activation of Soluble Guanylate Cyclase Attenuates Peroxynitrite-Induced Endothelial Dysfunction in Rat Aorta.

J Cardiovasc Pharmacol Ther. 2013 Jan;18(1):70-7. doi: 10.1177/1074248412455696. Epub 2012 Aug 22.

 

Weymann A, Schmack B, Okada T, Soos P, Istok R, Radovits T, Straub B, Barnucz E, Loganathan S, Paetzold I, Chaimow N, Schies C, Korkmaz S, Tochtermann U, Karck M, Szabo G (2013)

Reendothelialization of Human Heart Valve Neoscaffolds Using Umbilical Cord Derived Endothelial Cells.

Circ J. 2013;77(1):207-16. Epub 2012 Sep 21.

 

2012

Li S, Korkmaz S, Loganathan S, Weymann A, Radovits T, Barnucz E, Hirschberg K, Hegedüs P, Zhou Y, Tao L, Pali S, Veres G, Karck M, Szabo G (2012)

Acute Ethanol Exposure Increases the Susceptibility of the Donor Hearts to Ischemia/Reperfusion Injury after Transplantation in Rats.

PLoS One. 2012;7(11):e49237. doi: 10.1371/journal.pone.0049237. Epub 2012 Nov 14.

 

Weymann A, Schmack B, Okada T, Soos P, Istok R, Radovits T, Straub B, Barnucz E, Loganathan S, Paetzold I, Chaimow N, Schies C, Korkmaz S, Tochtermann U, Karck M, Szabo G (2012)

Reendothelialization of Human Heart Valve Neoscaffolds Using Umbilical Cord Derived Endothelial Cells.

Circ J. 2012 Dec 25;77(1):207-16. Epub 2012 Sep 21.

 

Barnucz E, Korkmaz S, Radovits T, Veres G, Hirschberg K, Hegedűs P, Páli S, Merkely B, Szabó G (2012)

Pharmacological modulation of the NO-cGMP-PKG pathway in a rat model of myocardial infarction.

Cardiologia Hungarica 2012; 42: 6-13.

 

Loganathan S, Radovits T, Korkmaz S, Hirschberg K, Barnucz E, Weymann A, Bömicke T, Arif R, Karck M, Szabó G (2012)

Enhancement of Myocardial and Vascular Function after Phosphodiesterase-5 Inhibition in a Rat Model.

Thorac Cardiovasc Surg. 2012 Jun;60(4):247-54. Epub 2012 Jan 17.

 

2011

Weymann A, Loganathan S, Takahashi H, Schies C, Claus B, Hirschberg K, Soós P, Korkmaz S, Schmack B, Karck M, Szabó G (2011)

Development and Evaluation of a Perfusion Decellularization Porcine Heart Model: Generation of Three-Dimensional Myocardial Neoscaffolds.

Circ J. 2011 Mar 25;75(4):852-60. Epub 2011 Feb 2

 

Radovits T, Korkmaz S, Miesel-Gröschel C, Seidel B, Stasch JP, Merkely B, Karck M, Szabó G (2011)

Pre-conditioning with the soluble guanylate cyclase activator Cinaciguat reduces ischaemia-reperfusion injury after cardiopulmonary bypass.

Eur J Cardiothorac Surg. 2011 Feb;39(2):248-55. Epub 2010 Jun 29.

 

2010

Loganathan S, Radovits T, Hirschberg K, Korkmaz S, Koch A, Karck M, Szabó G (2010)

Effects of Custodiol-N, a Novel Organ Preservation Solution, on Ischemia/Reperfusion Injury.

J Thorac Cardiovasc Surg. 2010 Apr;139(4):1048-56. Epub 2009 Nov 27

 

Hirschberg K, Radovits T, Korkmaz S, Loganathan S, Zöllner S, Seidel B, Páli Sz, Barnucz E, Merkely B, Karck M, Szabó G (2010)

Combined superoxide dismutase mimetic and peroxynitrite scavenger protects against neointima formation after endarterectomy in association with decreased proliferation and nitro-oxidative stress.

Eur J Vasc Endovasc Surg. 2010 Aug;40(2):168-75

 

2009

Korkmaz S, Radovits T, Barnucz E, Hirschberg K, Neugebauer P, Loganathan S, Veres G, Pali S, Seidel B, Zöllner S, Karck M, Szabo G (2009):

Pharmacological activation of soluble guanylate cyclase protects the heart against ischemic injury.

Circulation. 2009 Aug 25;120(8):677-86. Epub 2009 Aug 10

 

Korkmaz S, Radovits T, Barnucz E, Neugebauer P, Arif R, Hirschberg K, Loganathan S, Seidel B, Karck M, Szabó G (2009):

Dose-dependent effects of a selective phosphodiesterase-5-inhibitor on endothelial dysfunction induced by peroxynitrite in rat aorta.

Eur J Pharmacol. 2009 Aug 1;615(1-3):155-62. Epub 2009 May 29

 

Radovits T, Korkmaz S, Loganathan S, Barnucz E, Bömicke T, Arif R, Karck M, Szabó G (2009):

Comparative investigation of the left ventricular pressure-volume relationship in rat models of type 1 and type 2 diabetes mellitus.

Am J Physiol Heart Circ Physiol. 2009 Jul;297(1):H125-33. Epub 2009 May 8

 

Radovits T, Bömicke T, Kökény G, Arif R, Loganathan S, Kécsán K, Korkmaz S, Barnucz E, Sandner P, Karck M, Szabó G (2009)

The phosphodiesterase-5 inhibitor vardenafil improves cardiovascular dysfunction in experimental diabetes mellitus.

Br J Pharmacol 2009; 156 (6); 909-19

 

Korkmaz S, Maupoil V, Sobry C, Brunet C, Chevalier S, Freslon JL (2009)

An increased regional blood flow precedes mesenteric inflammation in rats treated by a phosphodiesterase 4 inhibitor.

Toxicol Sci. 2009 Jan;107(1):298-305. Epub 2008 Oct 15

 

2008

Loganathan S, Radovits T, Hirschberg K, Korkmaz S, Barnucz E, Karck M, Szabó G (2008):

Effects of Selective Phosphodiesterase-5-Inhibition on Myocardial Contractility and Reperfusion Injury After Heart Transplantation.

Transplantation. 2008 Nov 27;86(10):1414-8