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The Füllekrug Lab

Ärztlicher / Beruflicher Werdegang

2015

Honorary University title: apl. Professor

2006

Venia legendi for Biochemistry, University of Heidelberg equivalent to Associate Professor

seit 2004

Principal investigator, Internal Medicine IV, University of Heidelberg

1999 – 2003

Research associate, MPI Molecular Cell Biology, Heidelberg/Dresden, Prof. Dr. Kai Simons

1996 – 1998

Postdoctoral research fellow at the European Molecular Biology Laboratory Cell Biology Program, Heidelberg, Dr. T. Nilsson

1992 – 1995

PhD in Biochemistry, University of Göttingen, Prof. Dr. H. D. Söling

1992

Diploma in Chemistry, University of Göttingen

1989 – 1990

Academic exchange, University of Kent at Canterbury, England

Selected publications

Exner T, Romero-Brey I, Yifrach E, Rivera-Monroy J, Schrul B, Zouboulis CC, Stremmel W, Honsho M, Bartenschlager R, Zalckvar E, Poppelreuther M, Füllekrug J (2019) An alternative membrane topology permits lipid droplet localization of peroxisomal fatty acyl-CoA reductase 1. J Cell Sci 132, dx.doi.org/10.1242/jcs.223016

Poppelreuther M, Sander S, Minden F, Dietz MS, Exner T, Du C, Zhang I, Ehehalt F, Knuppel L, Domschke S, Badenhop A, Staudacher S, Ehehalt R, Stremmel W, Thiele C, Heilemann M, Füllekrug J (2018) The metabolic capacity of lipid droplet localized acyl-CoA synthetase 3 is not sufficient to support local triglyceride synthesis independent of the endoplasmic reticulum in A431 cells. Biochim Biophys Acta Mol Cell Biol Lipids 1863, 614, dx.doi.org/10.1016/j.bbalip.2018.03.003

Doll S, Proneth B, Tyurina YY, Panzilius E, Kobayashi S, Ingold I, Irmler M, Beckers J, Aichler M, Walch A, Prokisch H, Trumbach D, Mao G, Qu F, Bayir H, Füllekrug J, Scheel CH, Wurst W, Schick JA, Kagan VE, Angeli JP, Conrad M (2017) ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. Nat Chem Biol 13, 91, dx.doi.org/10.1038/nchembio.2239

Küch E, Vellaramkalayil R, Zhang I, Lehnen D, Brügger B, Stremmel W, Ehehalt R, Poppelreuther M, Füllekrug J (2014). Differentially localized acyl-CoA synthetase 4 isoenzymes mediate the metabolic channeling of fatty acids towards phosphatidyl­inositol. BBA Mol Biol Cell Lipids 1841, 227, doi.org/10.1016/j.bbalip.2013.10.018

Poppelreuther M, Rudolph B, Du C, Grossmann R, Becker M, Thiele C, Ehehalt R, Füllekrug J (2012) The N-terminal region of acyl-CoA synthetase 3 is essential for both the localization on lipid droplets and the function in fatty acid uptake. J Lipid Res 53, 888, dx.doi.org/10.1194/jlr.M024562

Weiss KH, Lozoya JC, Tuma S, Gotthardt D, Reichert J, Ehehalt R, Stremmel W, Füllekrug J (2008) Copper-induced translocation of the Wilson disease protein ATP7B independent of Murr1/COMMD1 and Rab7. Am J Pathol 173, 1783, dx.doi.org/10.2353/ajpath.2008.071134

Milger K, Herrmann T, Becker C, Gotthardt D, Zickwolf J, Ehehalt R, Watkins PA, Stremmel W, Füllekrug J (2006) Cellular uptake of fatty acids driven by the ER-localized acyl-CoA synthetase FATP4. J Cell Sci 119, 4678, dx.doi.org/10.1242/jcs.03280

Meder D, Shevchenko A, Simons K, Füllekrug J (2005) Gp135/podocalyxin and NHERF-2 participate in the formation of a preapical domain during polarization of MDCK cells. J Cell Biol 168, 303, dx.doi.org/10.1083/jcb.200407072

Schuck S, Manninen A, Honsho M, Füllekrug J, Simons K (2004) Generation of single and double knockdowns in polarized epithelial cells by retrovirus-mediated RNA interference. Proc Natl Acad Sci U S A 101, 4912, dx.doi.org/10.1073/pnas.0401285101

Füllekrug J, Suganuma T, Tang BL, Hong W, Storrie B, Nilsson T (1999) Localization and recycling of gp27 (hp24gamma3): complex formation with other p24 family members. Mol Biol Cell 10, 1939, dx.doi.org/10.1091/mbc.10.6.1939