Personen

PD Dr. med. Thomas Jänisch, PhD

Senior Scientist (Heidelberger Institut für Global Health)
Projektmitarbeiter (Sektion Klinische Tropenmedizin)


Ärztlicher / Beruflicher Werdegang

seit 2019

Projektmitarbeiter Sektion Klinische Tropenmedizin und Heidelberg Institute of Global Health (HIGH)

2010 – 2018

Arzt (Parasitologisches Speziallabor) Sektion Klinische Tropenmedizin, Zentrum für Infektiologie, und Abteilung Parasitologie, Zentrum für Infektiologie

2005 – 2009

Wissenschaftlicher Mitarbeiter, Sektion Klinische Tropenmedizin und Sektion Epidemiologie / Biostatistik, Zentrum für Infektiologie und Institut für Public Health, Universitätsklinikum Heidelberg

2003 – 2005

Studienarzt, Zink-Substitutions-Studie, Pemba, Sansibar, Tansania (in Zusammenarbeit mit der Johns Hopkins University Bloomberg School of Public Health und dem Public Health Laboratory Pemba)

2001 – 2005

PhD, Johns Hopkins University, Baltimore, USA (Global Disease Epidemiology and Control, Department of International Health, Bloomberg School of Public Health)

2000 – 2001

Mehrmonatige Gesundheitsprojekt-Evaluationen in Tansania (Consultancy) für die Gesellschaft für Internationale Zusammenarbeit (GIZ, Eschborn)

2000 – 2001

Assistenzarzt, Sektion Klinische Tropenmedizin, Universitätsklinikum Heidelberg

1998 – 2000

Arzt im Praktikum (AiP), Sektion Klinische Tropenmedizin, Universitätsklinikum Heidelberg

Wissenschaftlicher Werdegang

2014 – 2017

Habilitation im Fach Tropenmedizin und Infektionsepidemiologie
Titel: „The Global Expansion of Dengue – Clinical Staging and Prognostic Indicators“

2009 – 2014

Facharzt für Mikrobiologie, Virologie, und Infektionsepidemiologie

2001 – 2005

PhD, Johns Hopkins University, Baltimore, USA (Global Disease Epidemiology and Control, Department of International Health, Bloomberg School of Public Health)

2003 – 2005

Feldforschung in Sansibar, Tansania in Zusammenarbeit mit dem Public Health Laboratory Pemba (PHL-IdC)

1995 – 1998

Promotion (Dr. med.) am Institut für Virologie der Johann-Wolfgang-Goethe Universität, Frankfurt am Main (Prof. W. Doerr)

1988 – 1998

Studium der Humanmedizin an der Freien Universität Berlin und der Johann-Wolfgang-Goethe Universität Frankfurt

1989 – 1997

Studium der Philosophie (Abschluss Magister Artium) an der Freien Universität Berlin und der Johann-Wolfgang-Goethe Universität Frankfurt

Mitgliedschaften

WHO Expert Panel  for the review of the causality framework between Zika virus infection and neurological disorders

American Society for Tropical Medicine and Hygiene

International Association for Ecology and Health

seit 2015: Mitglied des Boards

 

Deutsche Gesellschaft für Tropenmedizin und Internationale Gesundheit e.V.

seit 2014: Fachausschuss ‚Forschung in den Tropen‘

Deutsche Gesellschaft für Epidemiologie

2010-2014: Sprecher der AG Infektionsepidemiologie

abgeschlossene Projekte

2011 – 2017

International Research Consortium on Dengue Risk Assessment, Management and Surveillance (IDAMS,  https://www.idams.eu/)

2016 – 2017

A Proof-of-Concept Approach for High-Throughput Screening of Protective vs. Harmful Antibody Profiles in Infectious Diseases (Projekt der Heidelberg Karlsruhe Research Partnership HeiKa im Rahmen des ZUK 49/2)

2013 – 2015

Correlating Antibody Responses Against New Pre-Erythrocytic Anti-Malaria Vaccine Candidates with Clinical Disease in a Representative Age-Stratified Population Sample from Nouna, Burkina Faso (Projekt des Instruments 5.2 "Innovationsfonds Frontier" im Rahmen des ZUK 49/2)

seit 2014

Spatio-Temporal Analysis of Pathogens and Their Environment - Tools for an Integrated Approach

2005 – 2009

Towards Sustainable Dengue Control (Denco)

Publications

Recent (2019-2020)

Ades AE, Brickley EB, Alexander N, Brown D, Jaenisch T, De Barros Miranda-Filho D, Pohl M, Rosenberger KD*, Soriano-Arandes A, Thorne C, De Alencar Ximenes RA, De Araújo TVB, Vivian I. Avelino-Silva, Bethencourt Castillo SE, Borja Aburto VH, Brasil P, Christie CDC, De Souza WV, Gatell Ramirez HL, Gotuzzo JEH, Guzman MG, Hoen B, Koopmans M, Turchi Martelli CM, Teixeira MM, Marques ETA, Miranda MC, Montarroyos UR, Moreira ME, Morris JG, Rockx B, Saba Villarroel PM, Segarra CS, Tami A, Turchi MD, Giaquinto C, de Lamballerie X, Wilder-Smith A, on behalf of the EC Zika Consortia Vertical Transmission Study Group. Zika virus infection in pregnancy: A protocol for the joint analysis of the prospective cohort studies of the ZIKAlliance, ZikaPLAN and ZIKAction consortia. BMJ Open, accepted

Heiss K, Heidepriem J, Fischer N, Weber LK, Dahlke C, Jaenisch T, Loeffler FF. Rapid Response to Pandemic Threats: Immunogenic Epitope Detection of Pandemic Pathogens for Diagnostics and Vaccine Development Using Peptide Microarrays. J Proteome Res. 2020 Sep 21. doi:10.1021/acs.jproteome.0c00484.

Cachay R, Schwalb A, Watanabe T, Guzman D, Jaenisch T, Guillén-Pinto D, Gotuzzo E. Case Report: Multiorgan Involvement with Congenital Zika Syndrome. Am J Trop Med Hyg. 2020 Jul 27. doi: 10.4269/ajtmh.20-0421.

Magalhaes T, Morais CNL, Jacques IJAA, Azevedo EAN, Brito AM, Lima PV, Carvalho GMM, Lima ARS, Castanha PMS, Cordeiro MT, Oliveira ALS, Jaenisch T, Lamb MM, Marques ETA, Foy BD. Follow-up household serosurvey in Northeast Brazil for Zika virus: sexual contacts of index patients have the highest risk for seropositivity. J Infect Dis. 2020 Sep 5:jiaa563. doi:101093/infdis/jiaa563.

Antia K, Boucsein J*, Deckert A, Dambach P, Racaite J, Surkiene G, Jaenisch T, Horstick O, Winkler V: Effects of International Labour Migration on the Mental Health and Well-Being of Left-Behind Children: A Systematic Review. Int. J. Environ. Res. Public Health 2020,17,4335;doi:1010.3390/ijerph17124335.

Duran P, Berman S, Niermeyer S, Jaenisch T, Forster T, Gomez Ponce de Leon R, De Mucio B, Serruya S. COVID-19 and newborn health: systematic review. Rev Panam Salud Publica. 2020 Apr 27;44:e54. doi: 10.26633/RPSP.2020.54. eCollection 2020.

Rosenberger KD*, Alexander N, Martinez E, Lum LCS, Dempfle CE, Junghanss T, Wills B, Jaenisch T; and the DENCO Clinical Study Group. Severe dengue categories as research endpoints - Results from a prospective observational study in hospitalised dengue patients. PLoS Negl Trop Dis. 2020 Mar 4;14(3):e0008076. doi: 10.1371/journal.pntd.0008076.

Vuong NL, Le Duyen HT, Lam PK, Tam DTH, Vinh Chau NV, Van Kinh N, Chanpheaktra N, Lum LCS, Pleités E, Jones NK, Simmons CP, Rosenberger K*, Jaenisch T, Halleux C, Olliaro PL, Wills B, Yacoub S. C-reactive protein as a potential biomarker for disease progression in dengue: a multi-country observational study. BMC Med. 2020 Feb 17;18(1):35. doi: 10.1186/s12916-020-1496-1.

Avelino-Silva VI*, Mayaud P, Tami A, Miranda MC, Rosenberger KD*, Alexander N, Nacul L, Segurado A, Pohl M, Bethencourt S, Villar LA, Viana IFT, Rabello R, Soria C, Salgado SP, Gotuzzo E, Guzmán MG, Martínez PA, López-Gatell H, Hegewisch-Taylor J, Borja-Aburto VH, Gonzalez C, Netto EM, Saba Villarroel PM, Hoen B, Brasil P, Marques ETA, Rockx B, Koopmans M, de Lamballerie X, Jaenisch T; and the ZIKAlliance Clinical Study Group. Study protocol for the multicentre cohorts of Zika virus infection in pregnant women, infants, and acute clinical cases in Latin America and the Caribbean: the ZIKAlliance consortium. BMC Infect Dis. 2019 Dec 26;19(1):1081. doi: 10.1186/s12879-019-4685-9.

Voordouw B, Rockx B, Jaenisch T, Fraaij P, Mayaud P, Vossen A, Koopmans M. Performance of Zika Assays in the Context of Toxoplasma gondii, Parvovirus B19, Rubella Virus, and Cytomegalovirus (TORCH) Diagnostic Assays. Clin Microbiol Rev. 2019 Dec 11;33(1). pii: e00130-18. doi: 10.1128/CMR.00130-18.

Pezzi L, Diallo M, Rosa-Freitas MG, Vega-Rua A, Ng LFP, Boyer S, Drexler JF, Vasilakis N, Lourenco-de-Oliveira R, Weaver SC, Kohl A, de Lamballerie X, Failloux AB; and the GloPID-R chikungunya, o'nyong-nyong and Mayaro virus Working Group: Brasil P, Busch M, Diamond MS, Drebot MA, Gallian P, Jaenisch T, LaBeaud AD, Lecuit M, Neyts J, Reusken CB, Ribeiro GS, Rios M, Rodriguez-Morales AJ, Sall A, Simmons G, Simon F, Siqueira AM. GloPID-R report on chikungunya, o'nyong-nyong and Mayaro virus, part 5: Entomological aspects. Antiviral Res. 2019 Dec 5:104670. doi: 10.1016/j.antiviral.2019.104670.

Pezzi L, LaBeaud AD, Reusken CB, Drexler JF, Vasilakis N, Diallo M, Simon F, Jaenisch T, Gallian P, Sall A, Failloux AB, Weaver SC, de Lamballerie X; GloPID-R chikungunya, o'nyong-nyong and Mayaro virus Working Group. GloPID-R report on chikungunya, o'nyong-nyong and Mayaro virus, part 2: Epidemiological distribution of o'nyong-nyong virus. Antiviral Res. 2019 Dec;172:104611. doi: 10.1016/j.antiviral.2019.104611

Pezzi L, Rodriguez-Morales AJ, Reusken CB, Ribeiro GS, LaBeaud AD, Lourenço-de-Oliveira R, Brasil P, Lecuit M, Failloux AB, Gallian P, Jaenisch T, Simon F, Siqueira AM, Rosa-Freitas MG, Vega Rua A, Weaver SC, Drexler JF, Vasilakis N, de Lamballerie X, on behalf of the GloPID-R chikungunya, o’nyong-nyong and the Mayaro virus Working Group, Boyer S, Busch M, Diallo M, Diamond MS, Drebot MA, Kohl A, Neyts J, Ng LFP, Rios M, Sall A, Simmons G. GloPID-R report on chikungunya, o'nyong-nyong and Mayaro virus, part 3: Epidemiological distribution of Mayaro virus, Antiviral Res. 2019 Dec;172:104610. doi: 10.1016/j.antiviral.2019.104610.

Messina JP, Brady OJ, Golding, N, Kraemer MUG, Wint GRW, Ray SE, Pigott DM, Shearer F, Johnson K, Earl L, Marczak LB, Shirude S, Weaver ND, Gilbert M, Velayudhan R, Jones P, Jaenisch T, Scott TW, Reiner RC, Hay SI. The current and future global distribution and population at risk of dengue. Nature Microbiology 2019, Sep;4(9):1508-1515. doi:10.1038/s41564-019-0476-8

Lizarazo E, Couto N, Vincenti-Gonzalez M, Raangs EC, Velasco Z, Bethencourt S, Jaenisch T, Friedrich AW, Tami A, Rossen JW. Innovative shotgun metagenomics approach for the genetic characterization of dengue viruses. Journal of Biotechnology 2019, June, X 2, 100009

Wilder-Smith A, Wei Y, Araújo TVB, VanKerkhove M, Turchi Martelli CM, Turchi MD, Teixeira M, Tami A, Souza J, Sousa P, Soriano-Arandes A, Soria-Segarra C, Sanchez Clemente N, Rosenberger KD*, Reveiz L, Prata-Barbosa A, Pomar L, Pelá Rosado LE, Perez F, Passos SD, Nogueira M, Noel TP, Moura da Silva A, Moreira ME, Morales I, Miranda Montoya MC, Miranda-Filho DB, Maxwell L, Macpherson CNL, Low N, Lan Z, LaBeaud AD, Koopmans M, Kim C, João E, Jaenisch T, Hofer CB, Gustafson P, Gérardin P, Ganz JS, Dias ACF, Elias V, Duarte G, Debray TPA, Cafferata ML, Buekens P, Broutet N, Brickley EB, Brasil P, Brant F, Bethencourt S, Benedetti A, Avelino-Silva VL*, Ximenes RAA, Alves da Cunha A, Alger J; Zika Virus Individual Participant Data Consortium. Understanding the relation between Zika virus infection during pregnancy and adverse fetal, infant and child outcomes: a protocol for a systematic review and individual participant data meta-analysis of longitudinal studies of pregnant women and their infants and children. BMJ Open. 2019 Jun 18;9(6): e026092. doi:10.1136/bmjopen-2018-026092.

Pezzi L, Reusken CB, Weaver SC, Drexler JF, Busch M, LaBeaud AD, Diamond MS, Vasilakis N, M.A. Drebot, A.M. Siqueira, G.S.. Ribeiro, A. Kohl, M. Lecuit, L.F.P. Ng, P. Gallian, X. de Lamballerie, and the GloPID-R Chikungunya, O'nyong-nyong and Mayaro virus Working Group: Boyer S, Brasil P, Diallo M, Failloux AB, Jaenisch T, Lourenço-de-Oliveira R, Neyts J, Rios M, Rodriguez-Morales AJ, Rosa-Freitas MG,  Sall A, Simmons G, Simon F, Vega Rua A: GloPID-R report on Chikungunya, O'nyong-nyong and Mayaro virus, part 1: Biological diagnostics. Antiviral Res 2019, Jun; 166:66-81. doi:10.1016/j.antiviral.2019.03.009

Brady OJ, Osgood-Zimmerman A, Kassebaum N, Ray SE, de Araéjo VEM, da Nóbrega AA, Frutuoso LCV, Lecca RCR, Stevens A, Zoca B, de Lima JM, Bogoch I, Mayaud P, Jaenisch T, Mokdad AH, Murray CHL, Hay SI, Reiner RC, Marinho F: The association between Zika virus infection and microcephaly in Brazil 2015-2017: An observational analysis of over 4 Million births. PLoS Med 2019 16(3): e1002755.

Thomas Jaenisch, Kirsten Heiss, Nico Fischer*, Carolin Geiger*, F. Ralf Bischoff, Gerhard Moldenhauer, Leszek Rychlewski, Ali Sié, Boubacar Coulibaly, Peter H. Seeberger, Lucjan S. Wyrwicz, Frank Breitling, Felix F. Loeffler. High-density peptide arrays help to identify linear immunogenic B cell epitopes in individuals naturally exposed to malaria infection. Mol Cell Proteomics 2019. doi: 101074/mcp.RA118000992.

Koopmans M, de Lamballerie X, Jaenisch T, on behalf of the Zikalliance Consortium.  Familiar barriers still unresolved — a perspective on the Zika virus outbreak research response. Lancet Inf Dis. 2019 Feb;19(2):e59-e62. doi.org/10.1016/S1473-3099(18)30497-3