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Portrait von Dr. med. Rawa Arif

Priv. - Doz. Dr. med. Rawa Arif

Arbeitsgruppenleiter (AG Kardiovaskuläre Gentherapie)
Oberarzt (Klinik für Herzchirurgie)


Arbeitsschwerpunkte

Gentherapie bei Marfan-Syndrom, Endotheliale Dysfunktion

Publikationen

2020

Kummer L, Zaradzki M, Vijayan V, Arif R, Weigand MA, Immenschuh S, Wagner AH, Larmann J (2020)

Vascular Signaling in Allogenic Solid Organ Transplantation - The Role of Endothelial Cells.

Front Physiol. 2020 May 8;11:443. doi: 10.3389/fphys.2020.00443. eCollection 2020. PMID: 32457653

 

Remes A, Franz M, Zaradzki M, Borowski C, Frey N, Karck M, Kallenbach K, Müller OJ, Wagner AH, Arif R (2020)

AAV-mediated TIMP-1 overexpression in aortic tissue reduces the severity of allograft vasculopathy in mice.

J Heart Lung Transplant. 2020 Apr;39(4):389-398. doi: 10.1016/j.healun.2020.01.1338. Epub 2020 Jan 30.

 

2019

Dib B, Seppelt PC, Arif R, Weymann A, Veres G, Schmack B, Beller CJ, Ruhparwar A, Karck M, Kallenbach K (2019)

Extensive aortic surgery in acute aortic dissection type A on outcome - insights from 25 years single center experience.

J Cardiothorac Surg. 2019 Nov 6;14(1):187. doi: 10.1186/s13019-019-1007-7.

 

Remes A, Franz M, Mohr F, Weber A, Rapti K, Jungmann A, Karck M, Hecker M, Kallenbach K, Müller OJ, Arif R, Wagner AH (2019)

AAV-Mediated Expression of AP-1-Neutralizing RNA Decoy Oligonucleotides Attenuates Transplant Vasculopathy in Mouse Aortic Allografts.

Mol Ther Methods Clin Dev. 2019 Oct 2;15:246-256. doi: 10.1016/j.omtm.2019.09.009. eCollection 2019 Dec 13.

 

Farag M, Arif R, Raake P, Kreusser M, Karck M, Ruhparwar A, Schmack B (2019)

Cardiac surgery in the heart transplant recipient: Outcome analysis and long-term results.

Clin Transplant. 2019 Oct;33(10):e13709. doi: 10.1111/ctr.13709. Epub 2019 Sep 30.

 

Arif R, Franz M, Remes A, Zaradzki M, Hecker M, Karck M, Müller OJ, Kallenbach K, Wagner AH (2019)

Reduction of Transplant Vasculopathy by Intraoperative Nucleic Acid-based Therapy in a Mouse Aortic Allograft Model.

Thorac Cardiovasc Surg. 2019 Sep;67(6):503-512. doi: 10.1055/s-0038-1673633. Epub 2018 Oct 23.

 

Kremer J, Farag M, Zaradzki M, Szabó G, Ruhparwar A, Kallenbach K, Karck M, Arif R (2019)

The reimplantation valve-sparing aortic root replacement technique for patients with Marfan syndrome: A single-center experience.

Sci Rep. 2019 Aug 19;9(1):12021. doi: 10.1038/s41598-019-48572-9.

 

Farag M, Veres G, Szabó G, Ruhparwar A, Karck M, Arif R (2019)

Hyperbilirubinaemia after cardiac surgery: the point of no return.

ESC Heart Fail. 2019 Aug;6(4):694-700. doi: 10.1002/ehf2.12447. Epub 2019 May 16.

 

Wagner AH, Zaradzki M, Arif R, Remes A, Müller OJ, Kallenbach K (2019)

Marfan syndrome: A therapeutic challenge for long-term care.

Biochem Pharmacol. 2019 Jun;164:53-63. doi: 10.1016/j.bcp.2019.03.034. Epub 2019 Mar 27. Review.

 

2018

Engelke J, Karmonik C, Rengier F, Partovi S, Popov AF, Osswald A, Arif R, Schmack B, Raake P, Simon AR, Doesch A, Weymann A, Lotz J, Karck M, Ruhparwar A (2018)

Competing Flow Between Partial Circulatory Support and Native Cardiac Output: A Clinical Computational Fluid Dynamics Study.

ASAIO J. 2018 Sep/Oct;64(5):636-642. doi: 10.1097/MAT.0000000000000701.

 

2017

Arif R, Zaradzki M, Remes A, Seppelt P, Kunze R, Schröder H, Schwill S, Ensminger SM, Robinson PN, Karck M, Müller OJ, Hecker M, Wagner AH, Kallenbach K (2017)

AP-1 Oligodeoxynucleotides Reduce Aortic Elastolysis in a Murine Model of Marfan Syndrome.

Mol Ther Nucleic Acids. 2017 Dec 15;9:69-79. doi: 10.1016/j.omtn.2017.08.014. Epub 2017 Sep 20.

 

Schmack B, Seppelt P, Weymann A, Alt C, Farag M, Arif R, Doesch AO, Raake PW, Kallenbach K, Mansur A, Popov AF, Karck M, Ruhparwar A (2017)

Extracorporeal life support with left ventricular decompression-improved survival in severe cardiogenic shock: results from a retrospective study.

PeerJ. 2017 Sep 29;5:e3813. doi: 10.7717/peerj.3813. eCollection 2017.

 

Farag M, Borst T, Sabashnikov A, Zeriouh M, Schmack B, Arif R, Beller CJ, Popov AF, Kallenbach K, Ruhparwar A, Dohmen PM, Szabó G, Karck M, Weymann A (2017)

Surgery for Infective Endocarditis: Outcomes and Predictors of Mortality in 360 Consecutive Patients.

Med Sci Monit. 2017 Jul 25;23:3617-3626.

 

Weymann A, Farag M, Sabashnikov A, Fatullayev J, Zeriouh M, Schmack B, Arif R, Müller F, Alt C, Raake P, Prakash Patil N, Popov AF, Rüdiger Simon A, Karck M, Ruhparwar A; Heidelberg-Cologne-Harefield Cardiothoracic Transplantation & Mechanical Circulatory Support Outcomes Research Group (2017)

Central Extracorporeal Life Support With Left Ventricular Decompression to Berlin Heart Excor: A Reliable "Bridge to Bridge" Strategy in Crash and Burn Patients.

Artif Organs. 2017 Jun;41(6):519-528. doi: 10.1111/aor.12792. Epub 2016 Nov 8.

 

Farag M, Nikolic M, Arif R, Schmack B, Sabashnikov A, Zeriouh M, Popov AF, Ruhparwar A, Karck M, Weymann A (2017)

Cardiac Surgery in Patients With Previous Hepatic or Renal Transplantation: A Pair-Matched Study.

Ann Thorac Surg. 2017 May;103(5):1467-1474. doi: 10.1016/j.athoracsur.2016.08.092. Epub 2016 Nov 17.

 

Farag M, Arif R, Sabashnikov A, Zeriouh M, Popov AF, Ruhparwar A, Schmack B, Dohmen PM, Szabó G, Karck M, Weymann A (2017)

Repair or Replacement for Isolated Tricuspid Valve Pathology? Insights from a Surgical Analysis on Long-Term Survival.

Med Sci Monit. 2017 Feb 25;23:1017-1025.

 

Farag M, Patil NP, Sabashnikov A, Arif R, Szabó G, Kallenbach K, Ruhparwar A, Karck M, Brenner T, Hofer S, Weymann A (2017)

Comparison of Two Miniaturized Cardiopulmonary Bypass Systems Regarding Inflammatory Response.

Artif Organs. 2017 Feb;41(2):139-145. doi: 10.1111/aor.12750. Epub 2016 Sep 22.

 

2016

Arif R, Farag M, Zaradzki M, Reissfelder C, Pianka F, Bruckner T, Kremer J, Franz M, Ruhparwar A, Szabo G, Beller CJ, Karck M, Kallenbach K, Weymann A (2016)

Ischemic Colitis after Cardiac Surgery: Can We Foresee the Threat?

PLoS One. 2016 Dec 15;11(12):e0167601. doi: 10.1371/journal.pone.0167601. eCollection 2016.

 

Kremer J, Farag M, Arif R, Brcic A, Sabashnikov A, Schmack B, Popov AF, Karck M, Dohmen PM, Ruhparwar A, Weymann A (2016)

Total Artificial Heart Implantation After Undifferentiated High-Grade Sarcoma Excision.

Med Sci Monit Basic Res. 2016 Nov 2;22:128-131.

 

Hirschberg K, Wiedmann F, Zitron E, Fortner P, Riffel JH, Chorianopoulos E, Gdynia G, Mechtersheimer G, Andrassy M, Szabó G, Arif R, Katus HA, Buss SJ (2016)

Incidental finding of a giant intracardiac angioma infiltrating both ventricles in a 35-year-old woman: a case report.

J Med Case Rep. 2016 Apr 12;10:94. doi: 10.1186/s13256-016-0860-4.

 

Arif R, Farag M, Gertner V, Szabó G, Weymann A, Veres G, Ruhparwar A, Bekeredjian R, Bruckner T, Karck M, Kallenbach K, Beller CJ (2016)

Female Gender and Differences in Outcome after Isolated Coronary Artery Bypass Graft Surgery: Does Age Play a Role?

PLoS One. 2016 Feb 4;11(2):e0145371. doi: 10.1371/journal.pone.0145371. eCollection 2016.

 

Seppelt PC, Schwill S, Weymann A, Arif R, Weber A, Zaradzki M, Richter K, Ensminger S, Robinson PN, Wagner AH, Karck M, Kallenbach K (2016)

Loss of Endothelial Barrier in Marfan Mice (mgR/mgR) Results in Severe Inflammation after Adenoviral Gene Therapy.

PLoS One. 2016 Feb 3;11(2):e0148012. doi: 10.1371/journal.pone.0148012. eCollection 2016.

 

Arif R, De Simone R, Karck M, Auch-Schwelk W (2016)

Coronary Stenosis Associated with a Giant Coronary Aneurysm.

J Card Surg. 2016 Feb;31(2):98-9. doi: 10.1111/jocs.12658. Epub 2015 Dec 2. No abstract available.

 

2015

Arif R, Eichhorn F, Kallenbach K, Seppelt P, Ruhparwar A, Dienemann H, Karck M (2015)

Resection of thoracic malignancies infiltrating cardiac structures with use of cardiopulmonary bypass.

J Cardiothorac Surg. 2015 Jun 25;10:87. doi: 10.1186/s13019-015-0296-8.

 

Beller CJ, Farag M, Wannaku S, Seppelt P, Arif R, Ruhparwar A, Karck M, Weymann A, Kallenbach K (2015)

Gender-specific differences in outcome of ascending aortic aneurysm surgery.

PLoS One. 2015 Apr 22;10(4):e0124461. doi: 10.1371/journal.pone.0124461. eCollection 2015.

 

Karmonik C, Partovi S, Rengier F, Meredig H, Farag MB, Müller-Eschner M, Arif R, Popov AF, Kauczor HU, Karck M, Ruhparwar A (2015)

Hemodynamic assessment of partial mechanical circulatory support: data derived from computed tomography angiographic images and computational fluid dynamics.

Cardiovasc Diagn Ther. 2015 Apr;5(2):160-5. doi: 10.3978/j.issn.2223-3652.2015.03.03.

 

Takahashi H, Arif R, Almashhoor A, Ruhparwar A, Karck M, Kallenbach K (2015)

Long-term results after surgical treatment of postinfarction ventricular septal rupture.

Eur J Cardiothorac Surg. 2015 Apr;47(4):720-4. doi: 10.1093/ejcts/ezu248. Epub 2014 Jul 3.

 

2014

Takahashi H, Gertner V, Arif R, Kallenbach K, Karck M, Ruhparwar A (2014)

Facilitated aortic valve replacement with complete sternotomy and minimal skin incision using endoscopy: a case of surgical report.

Ann Thorac Cardiovasc Surg. 2014;20 Suppl:709-12. doi: 10.5761/atcs.cr.12.01917. Epub 2013 Mar 26.

 

Arif R, Ruhparwar A, Kallenbach K, Weymann A, Schmack B, Karck M, Gorenflo M (2014)

Amplatzer™ occlusion device implantation in a patient with biventricular HeartWare®.

Int J Artif Organs. 2014 Jan;37(1):93-5. doi: 10.5301/ijao.5000260. Epub 2014 Jan 30.

 

2013

Kallenbach K, Kojic D, Oezsoez M, Bruckner T, Sandrio S, Arif R, Beller CJ, Weymann A, Karck M (2013)

Treatment of ascending aortic aneurysms using different surgical techniques: a single-centre experience with 548 patients.

Eur J Cardiothorac Surg. 2013 Aug;44(2):337-45. doi: 10.1093/ejcts/ezs661. Epub 2013 Jan 7.

 

Takahashi H, Arif R, Kallenbach K, Tochtermann U, Karck M, Ruhparwar A (2013)

Surgical treatment of aortic valve endocarditis with left ventricular-aortic discontinuity.

Ann Thorac Surg. 2013 Jul;96(1):72-6. doi: 10.1016/j.athoracsur.2013.03.060. Epub 2013 May 11.

 

Radovits T, Arif R, Bömicke T, Korkmaz S, Barnucz E, Karck M, Merkely B, Szabó G (2013)

Vascular dysfunction induced by hypochlorite is improved by the selective phosphodiesterase-5-inhibitor vardenafil.

Eur J Pharmacol. 2013 Jun 15;710(1-3):110-9. doi: 10.1016/j.ejphar.2013.04.012. Epub 2013 Apr 23.

 

Beller CJ, Schmack B, Seppelt P, Arif R, Bekeredjian R, Krumsdorf U, Katus HA, Karck M, Kallenbach K (2013)

The groin first approach for transcatheter aortic valve implantation: are we pushing the limits for transapical implantation?

Clin Res Cardiol. 2013 Feb;102(2):111-7. doi: 10.1007/s00392-012-0502-9. Epub 2012 Aug 5.

 

2012

Arif R, Seppelt P, Schwill S, Kojic D, Ghodsizad A, Ruhparwar A, Karck M, Kallenbach K (2012)

Predictive risk factors for patients with cirrhosis undergoing heart surgery.

Ann Thorac Surg. 2012 Dec;94(6):1947-52. doi: 10.1016/j.athoracsur.2012.06.057. Epub 2012 Aug 24.

 

Loganathan S, Radovits T, Korkmaz S, Hirschberg K, Barnucz E, Weymann A, Bömicke T, Arif R, Karck M, Szabó G (2012)

Enhancement of myocardial and vascular function after phosphodiesterase-5 inhibition in a rat model.

Thorac Cardiovasc Surg. 2012 Jun;60(4):247-54. doi: 10.1055/s-0031-1298059. Epub 2012 Jan 17.

 

2010

Gertner V, Bordel V, Tochtermann U, Kallenbach K, Verch M, Ungerer M, Piontek P, Arif R, Hasani MR, Takahashi H, Farag M, Ruhparwar A, Karck M, Ghodsizad A, Hasani AR (2010)

Management of biventricular assist device implantation in patients with necrotic pancreatitis.

Heart Surg Forum. 2010 Dec;13(6):E413-4. doi: 10.1532/HSF98.20101067.

 

2009

Korkmaz S, Radovits T, Barnucz E, Neugebauer P, Arif R, Hirschberg K, Loganathan S, Seidel B, Karck M, Szabó G (2009)

Dose-dependent effects of a selective phosphodiesterase-5-inhibitor on endothelial dysfunction induced by peroxynitrite in rat aorta.

Eur J Pharmacol. 2009 Aug 1;615(1-3):155-62. doi: 10.1016/j.ejphar.2009.05.020. Epub 2009 May 29

 

Radovits T, Korkmaz S, Loganathan S, Barnucz E, Bömicke T, Arif R, Karck M, Szabó G (2009)

Comparative investigation of the left ventricular pressure-volume relationship in rat models of type 1 and type 2 diabetes mellitus.

Am J Physiol Heart Circ Physiol. 2009 Jul;297(1):H125-33. doi: 10.1152/ajpheart.00165.2009. Epub 2009 May 8.

 

Radovits T, Bömicke T, Kökény G, Arif R, Loganathan S, Kécsán K, Korkmaz S, Barnucz E, Sandner P, Karck M, Szabó G (2009)

The phosphodiesterase-5 inhibitor vardenafil improves cardiovascular dysfunction in experimental diabetes mellitus.

Br J Pharmacol. 2009 Mar;156(6):909-19. doi: 10.1111/j.1476-5381.2008.00098.x. Epub 2009 Mar 4.

 

2007

Radovits T, Zotkina J, Lin LN, Bömicke T, Arif R, Gerö D, Horváth EM, Karck M, Szabó C, Szabó G (2007)

Poly(ADP-Ribose) polymerase inhibition improves endothelial dysfunction induced by hypochlorite.

Exp Biol Med (Maywood). 2007 Oct;232(9):1204-12.